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60 Cards in this Set
- Front
- Back
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Some drugs are NOT forgiving...
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IV K - deadly in children
Heparin - pt can bleed out Insulin - glucose can drop to deadly levels |
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Halogenated ethers
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Isoflorane (Forane)
Desflurane (Suprane) |
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Magnesium sulfate
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IV = stop convulsions (post labour)
IM = supplement PO = laxative effect Topical = astringent |
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Chloramphenicol
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Grey Baby syndrome
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Narrow TI drugs
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Why Did Percribers want Little Tis?
Warfarin Digoxin Phenytoin Lithium Theophillin |
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Opioids (codiene, morphine)
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Slow GI tract (slow absorption of other drugs)
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Metoclopramide (Reglan)
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Increase gastric emptying (increase absorption of other drugs)
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Ciproflaxin + Maalox
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Maalox binds to Cipro, less Cipro bioavailable (decrease amount of drug absorbed)
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Drug Interactions
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Rifampin + Loestrin = unplanned pregnancy (hepatic enzyme induction)
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Drug Interactions
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Cimetidine (Tagamet) + Carbamazepine (Tegretol)
Fluoxitine (Prozac) + Dextromethorphan (DM) (hepatic enzyme inhibition) |
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Increased Lithium levels
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ACE inhibitors
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Absorption delayed or reduced by food
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Alendronate (Fosamax)
Ciproflaxin (Cipro) "Food Coming later" |
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Absorption increased by food
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Zidovudine (Retrovir)
Cefuroxime axetil (Ceftin) "RC Cola" |
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No vit K foods (spinach, coffee, tomatoes)
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Warfarin
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No tyramine (fermented foods)
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MAOI
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No grapefruit juice
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CC blockers - Felodipine (Plendil)
Statins - Atorvastatin (Lipitor) |
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Alcohol
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NO DIAZEPAMS!
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Non receptor mechanism
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Psyllium (Metamucil)
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NE Degradation
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MAO
A = nerve mitochondria, intestine B = synaptic cleft COMT (removes methyl group) |
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Buspirone (Buspar)
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A = Anti-anxiety
Serotonin (5-HT) agonist |
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Sumatriptan (Imitrex)
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DUH! Cerebral vasoconstriction
Serotonin (5-HT) agonist |
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Mirtazepine (Remeron)
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2A = Atypical antipsychotic
Serotonin (5-HT) antagonist |
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Metoclopramidine (Reglan)
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4 GI motility
Serotonin (5-HT) antagonist |
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Drugs that effect neurotransmitters
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Does Sally Ever Really Practice Tennis?
Depakene = synthesis Serpasil = storage Ritalin = release Eldepryl = degradation Prozac = re-uptake Tenormin = binding |
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Acute alcoholism
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Thiamine (fatty liver)
Spirinolactone (liver edema) |
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Chronic alcoholism
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"AT last, im LIBerated from alcohol"
Lorazepam (Ativan) FIRST Chlordiazepoxide (Librium) SECOND |
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Chloral Hydrate
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is not for CHildren!
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Phenobarbital
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Long acting antiseizure
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Clonazepam (Klonopin)
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Absence seizure (kids)
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Diazepam (Valium)
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Anti-seizure, skeletal muscle relaxant
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Midazolam (Versed)
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Sedation
Short duration, fast acting |
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Temazepam (Restoril)
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No REM sleep, amnesia! like BATMAN!
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Alprazolam (Xanax)
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Anti anxiety AND panic disorder
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Adverse effects of BZD
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presented by "DA CATaractS"
Dysphoria Ataxia CNS depression Amnesia Tolerance, addiction, withdrawl Slurred speech |
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Flumanzenil (Romazicon)
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BDZ receptor ANTAGONIST, careful of convulsions!
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Hydroxyzine (Vistaril)
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Antihistamine, anti-anxiety
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Paroxetine (Paxil CR)
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SSRI, GAD, long acting
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Venlafaxine (Effector XR)
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SNRI, GAD
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Zolpidem (Ambien, Ambien CR)
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GABA antagonist, highly addictive!
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Ramelteon (Rozerem)
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Melatonin receptor agonist, maintenance of circadium rhythym
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Propofol (Diprivan)
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Anesthetic
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Fentanyl (sublimaze)
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Analgesic and anaethetic
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Drug Induced Parkinsons
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"They Have Completely Regressed"
Chlorpromazine (Thorazine) Haloperidol (Haldol) Prochlorperazine (Compazine) Metoclorpramide (Reglan) |
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Levodopa/Carbidopa (Sinemet)
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Converted to dopamine in CNS (deliver exogenous dopamine)
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Selegine (Elderpryl)
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MAO Inhibitor (increase endogenous dopamine), monitor blood pressure, jittery, insomnia
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Entacapone (Comtan)
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COMT inhibitor (increase endogenous dopamine), urine discoloration, monitor liver cells
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Non ergot - dopamine receptor agonist
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Pramipexole (Mirapex)
Ropinirole (Requip) |
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Ergot
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Bromocriptine (Parlodel) - cardiac valve disease, prolactin inhibition
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Anticholinergics
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Benztropine (Cogentin) - blurred vision, dry mouth, constipation, urinary retention
Hallucinations |
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Valproic Acid (Depakene)
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Petit Mal, GABA inhibitor, hepatic failure, pancreatitis
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Clonazepam (Klonopin)
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Petit Mal, can ppt Grand Mal, inhibits learning
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Grand Mal
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Generations:
First - dilantin, cerebyx, tegretol, phenobarbital, valproic acid Second - neurontin,lamictal Third - keppra, trileptal |
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Phenytoin (Dilantin)
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1st gen Grand Mal, oral, narrow TI, monitor blood levels, see AE
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Carbamazepine (Tegratol)
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1st gen Grand Mal, trigeminal neuralgia, aplastic anemia, hematologic monitoring, Na retention in elderly
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Phenobarbital
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1st gen Grand Mal - long acting
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Valproic Acid (Depakene), Divalproex (Depakote)
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1st gen Grand Mal
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Gabapentin (Neurontin)
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2nd gen Grand Mal - renal elmination, pain tx, syncope, not in use, see NOTES
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Lamotrigine (Lamictal)
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"Lat me see your rash"
2nd gen Grand Mal - stabilizes membrane, treat bipolar disorder, SJS rash |
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Levetiracetam (Keppra)
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3rd gen Grand Mal, anemia
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Oxcarbazepine (Trileptal)
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3rd gen Grand Mal, hyponatremia
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