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76 Cards in this Set
- Front
- Back
GnRH
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stimulates release of FSH, LH
released intermittently & controlled by neural pulse in hypothalamus |
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somatotropin (growth hormone)
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growth of all organs except brain & eye
(+): GHRH (somatocrinin), (-) GHRIH (somatostatin) |
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acromegaly
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growth hormone hypersecretion
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prolactin
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stimulates lactation during postpartum period
(-): dopamine |
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lutenizing hormone (LH)
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male: stimulates androgen synthesis
female: stimulates development of ovarian follicles, induces ovulation, produces estrogens & progesterone |
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follicle stimulating hormone (FSH)
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male: sperm maturation
female: stimulates development of ovarian follicles, induces ovulation, produces estrogens & progesterone |
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adrenocorticotropic hormone (ACTH)
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stimulates release of glucocorticoids, mineralocorticoids from adrenal cortex
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thyroid stimulating hormone (TSH)
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stimulates iodic ion uptake by thyroid gland (critical step in biosynthesis of thyroxine)
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oxytocin
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increases frequency & force of uterine contraction, stimulates milk ejection
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vasopressin (ADH)
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regulation of body fluid osmolality (thru renal conservation of water), vasoconstriction
released d/t: increased plasma osmolality, hypovolemia/hypotension |
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diabetes insipidus
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excretion of large volumes of dilute urine, polydipsia
nephrogenic: d/t insufficient renal response to ADH central: d/t inadequate secretion of ADH from posterior pituitary |
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thyroxine
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growth & development
maintainence of BMR CV effects increased glucose absorption from gut decrease lipids by enhancing lipolytic response to fat cells |
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insulin
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from beta cells of pancreatic islets
secreted in response to increased blood glucose aids in entry of glucose into muscle, adipose, other tissues stimulates storage of glucose in liver as glycogen fat sparing effect d/t synthesis of FA's in liver, inhibition of fat breakdown in adipose tissue decreases protein catabolism (-): somatostatin |
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diabetes mellitus
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insulin dependent: no insulin secretion d/t destruction of beta cells
tx: insulin replacement therapy non-insulin dependent: insulin resistance b/c target tissue fails to respond properly to insulin tx: eliminate obesity, change diet, hypoglycemic agents |
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glucagon
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from alpha cells of pancreatic islets
increases blood glucose by: stimulating glycogenolysis activating hepatic gluconeogenesis released in response to hypoglycemia, increased plasma amino acids, exercise (-): somatostatin |
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somatostatin
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from delta cells of pancreatic islets
inhibits insulin, glucagon, growth hormone |
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glucocorticoids
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prototype: cortisol
increases & maintains normal blood glucose concentration anti-inflammatory & immunosuppressive combat stress d/t trauma, fright, infection, or dz site: ZF, ZR of adrenal cortex |
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mineralocorticoids
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prototype: aldosterone
regulate Na & K concentrations in extracellular fluid aldosterone: causes increased reabsorption of Na, H2O & increased secretion of K in distal tubule of kidney site: ZG of adrenal cortex |
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hyperadrenocorticism
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excessive production of cortisol d/t:
primary adrenal tumor (ACTH independent) excess secretion of ACTH d/t pituitary tumor (ACTH dependent) |
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hypoadrenocorticism
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deficiency in cortisol & aldosterone d/t infection or autoimmune destruction of adrenal cortex
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principles of glucocorticoid therapy
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alternate day therapy
gradual withdrawal from chronic use do NOT use w/ NSAIDs, diabetics, pregnant animals |
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PGF-2alpha
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luteolytic agent produced by uterus
mediates decrease in circulating progesterone via luteolysis (CL regression) used to induce abortion, decrease estrous cycle length & thereby hasten onset of estrus, stimulate uterine contraction in parturition, tx uterine infections |
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gonadorelin
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synthetic GnRH: stimulates release of FSH, LH
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clinical uses of gonadorelin
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induction of ovulation
tx of cystic ovaries in cattle (tx of choice) termination of estrus in ferrets diagnostic use: pituitary function test |
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chorionic gonadotropin (HCP)
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has LH-like activity
produced by cells of placenta & extracted from urine of pregnant women |
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clinical uses of chorionic gonadotropin
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infertility therapy
tx of cystic ovaries tx of impotence in stallions cryptorchidism |
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cosyntropin
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truncated ACTH agonist
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clinical uses of cosyntropin
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ACTH stimulation test: drug administered & cortisol measured just before & 30-60 minutes later
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clinical uses of oxytocin
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induction of labor
to assist in parturition (uterine inertia) tx uterine prolapse stimulate milk letdown in dogs |
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side effects of oxytocin
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OD or repeated dosing: painful contractions or uterine rupture & fetal death
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clinical uses of vasopressin
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tx of central diabetes insipidus
tx esophageal closure in ruminants |
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side effects of vasopression
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bronchoconstriction
water intoxication |
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desmopressin acetate
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selective vasopressin V2 receptor agonist (V2: collecting ducts of kidney)
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clinical uses & side effects of desmopressin acetate
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tx central diabetes insipidus
dx of diabetes insipidus modified water deprivation test tx of von Willebrand's dz (to induce hemostasis) side effects: water intoxication |
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levothyroxine
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=T4
drug of choice for tx of hypothyroidism in all species |
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side effects/special considerations with levothyroxine
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dogs need higher dose than other species d/t higher metabolic rate & poor oral absorption
OD --> hyperthyroidism care should be taken in patient's w/ Addison's, DM, CV dz increases activity of epi & norepi, decreases efficacy of insulin & digoxin, significant interaction w/ ketamine may occur |
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liothyronine
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=T3
faster acting than Levo, but shorter half life & higher cost may lack physiologically diverse tissue specific distribution used rarely (critically ill patients) |
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methimazole
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drug of choice for tx of hyperthyroidism
long acting, orally available blocks iodination of tyrosine residues of thyroglobulin & condensation of DIT & MIT onset of effects: 5+ days, 2-3 wks to normalize T4 |
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side effects of methimazole
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bitter taste, anorexia, vomiting, transient lethargy
rare toxicity: thrombocytopenia, amnesia OD does NOT cause hypothyroidism |
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propranolol (used in hyperthyroidism)
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beta blocker
used as adjunct to control tachycardia & other cardiac abnormalities assoc. w/ severe hyperthyroidism normal dosage should be decreased in hyperthyroid cats side effects: bronchoconstriction, hypoglycemia, hypotension, bradycardia |
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shorting acting insulin products
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rapid onset (30 min), short duration (5-8 hrs)
can be given IV in emergencies ex. regular (crystalline) insulin |
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intermediate acting insulin products
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last 18-24 hrs
lente: insulin of choice for dogs w/ uncomplicated DM NPH: often used in dogs in combo w/ regular or lente insulin |
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long acting insulin products
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onset: 4-6 hrs
prolonged, flat peak of action (20-36 hrs) provide low basal conc. thru out day ex. PZI, ultralente |
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glipizide
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adjunct in management of non-insulin dependent DM
response variable, can be used w/ insulin |
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mechanisms of action of glipizide
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blocks K channels in pancreatic B cell mems --> depolarization induced insulin release from functioning B cells
decreases glucagon level increases binding of insulin to its receptors |
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side effects of glipizide
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hypoglycemia, hepatotoxicity, contraindicated w/ diabetic ketoacidosis
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glyburide
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adjunct in management of non-insulin dependent DM
longer duration of action than glipizide (24 hrs vs. 10-16 hrs) not widely used |
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mitotane (Lysodren)
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most commonly used drug to tx Cushing's
DDT insecticide analog selectively destroys adrenal ZF & ZR |
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side effects of mitotane (Lysodren)
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high doses chemically ablate adrenal cortex --> adrenal insufficiency
highly toxic GI upset CNS depression liver damage |
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ketoconazole
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used to tx Cushing's
cytochrome p450scc & 17alpha-hydroxylase inhibitor --> blocks synthesis of ALL cholesterol derived steroids |
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side effects of ketoconazole
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vomiting, anorexia, teratogenic
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pergolide
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used to tx Cushing's in horses
dopamine (D2) receptor agonist --> inhibits release of ACTH |
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bromocriptine
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used to tx Cushing's in horses
ergot derived dopamine receptor agonist --> inhibits release of ACTH therapy only palliative tolerance often develops |
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L-Deprenyl (Anipryl)
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used to tx uncomplicated Cushing's
irreversible monoamine oxidase B inhibitor --> blocks degradation of dopamine & other catecholamines --> inhibits release of ACTH |
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trilostane
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used to tx Cushing's (not available commercially)
inhibits enzyme that converts pregnenolone to progesterone --> inhibits all prenenolone derived steroids |
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deoxycorticosterone (Percorten)
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used in tx of Addison's
naturally occurring mineralocorticoid short & long acting forms (given IM) |
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side effects of deoxycorticosterone (Percorten)
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hypokalemia, hypernatremia, muscle weakness, hypertension
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fludrocortisone
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used in tx of Addison's
orally active, synthetic, long-acting mineralocorticoid |
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altrenogest (Regumate)
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synthetic orally active progretin
used to control estrous cycle in mare & pig use of PGF 2alpha immediately after therapy will induce estrous contraindicated in pregnant mare --> fetal abnormalities |
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synchro-mate B (SMB)
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progesterone-estrogen combo (not available in US)
used for estrous synchronization in cattle & goats ear implant + injection estrogen --> luteolysis via PG release progestin --> inhibits LH secretion --> inhibits CL function |
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stanazolol (Winstrol-V)
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anabolic steroid
potentially useful as adjunct to management of catabolic dz states recommended to stimulate erythropoiesis, increase appetite, promote wt. gain, increase strength & vitality |
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side effects of stanazolol (Winstrol-V)
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hepatotoxicity, wt. gain, sodium & water retention, CARCINOGENIC
contraindicated w/ benign prostatic hyperplasia |
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finasteride
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used to tx BPH
irreversible 5alpha-reductase inhibitor: blocks conversion of testosterone to dihydro-testosterone --> prostatic involution adverse effects: impotence |
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hydrocortisone
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=cortisol, Solu-Cortef
short acting natural glucocorticoid |
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methylprednisolone (Medrol)
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prednisolone derivative
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betamethasone
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highly potent, long acting injectable glucocorticoid
clinical uses: pruritis ophthalmic conditions skin conditions |
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prednisolone
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most widely used glucocorticoid in small animals
clinical uses: adrenal insufficiency shock inflammatory conditions of skin & joints supportive care during periods of stress prednisone: prodrug metabolized in liver to prednisolone |
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dexamethasone
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most widely used glucocorticoid in large animals
long acting clinical uses: dermatoses inflammatory conditions involving joints management of hydrocephalus in toy breeds adjunct to cranial & spinal trauma tx of shock |
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triamcinolone (Vetalog)
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potent synthetic glucocorticoid
clinical uses: arthritis allergic & dermatologic conditions soft tissue injuries (horses) |
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uses of glucocorticoids
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inflammation/allergies
to suppress immune system shock cancer chemo inflammatory ophthalmic conditions inflammatory skin conditions |
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thyroid hormone synthesis
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1. uptake of iodiide from diet
2. oxidation & iodination (thyroglobulin --> mono- or di-iodotyrosine) 3. condensation (DIT + DIT = T4, DIT + MIT = T3) 4. proteolysis: hormone released 5. deiodination: much of circulating T3 formed by deiodination of T4 in peripheral tissues |
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types & clinical signs of hypothyroidism
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congenital: dwarfish, dullness, retention of puppy coat, neuro abnormalities (rare)
acquired: bilaterally symmetric alopecia, myxedema, obesity, lethargy, bradycardia, weakness (common) |
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causes & clinical signs hyperthyroidism
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d/t malignant tumor of thryoid gland (inc. T3 & T4) or pituitary thyrotropes (inc. TSH)
palpable thyroid nodule, wt. loss, PU/PD, hyperactivity, tachycardia, derm lesions, hypertension |
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clinical uses of anabolic steroids
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aplastic anemia (dogs, cats)
myeloproliferative dz lymphoma assoc. w/ non-regen. anemia to inc. athletic performance in horses |
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membrane receptors
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H20 soluble hormones, peptides, polypeps (activation of 2nd messengers)
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intracellular receptors
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lipid soluble hormones, steroids, thyroid hormones (regulation of gene expression)
cortisol aldosterone estrogen progesterone testosterone thyroxine |