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7 Cards in this Set

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Digoxin (Lanoxin)
Class: Cardiac glycoside
Use: Treatment for Congestive Heart Failure (CHF)
MOA: Inhibits the Na-K ATPase (Sodium/Potassium Pump)of cardiac muscle cells. Increases cardiac contractility, decreases Heart Rate and AV nodal conduction.
Digitoxin (Crystodigin)
Class: Cardiac glycoside
Use: Treatment for Congestive Heart Failure (CHF)
MOA: Inhibits the Na-K ATPase (Sodium/Potassium Pump)of cardiac muscle cells. Increases cardiac contractility, decreases Heart Rate and AV nodal conduction.
Clonidine (Catapres)
Centrally - Acting Sympathetic Agonist
Receptor: Alpha 2 Agonist
MOA: Turns off NE release in the brain.
Uses: HTN
S.E.- Vasodilation, decreased HR, Decreased BP, sedation, dry mouth, nasal stuffiness, constipation, edema.
Notes: DO NOT d/c abruptly (causes rebound HTN).
Take at night due to sedation.
Methyldopa (Aldomet)
Centrally - Acting Sympathetic Agonist
Receptor: Alpha 2 Agonist
MOA: Turns off NE release in the brain.
Uses: HTN
S.E.- Vasodilation, decreased HR, Decreased BP, sedation, dry mouth, nasal stuffiness, edema.
Notes: DO NOT d/c abruptly (causes rebound HTN).
Take at night due to sedation.
Reserpine(Serpasil)
Peripherally-Acting Sympathetic Agonist
MOA: Depletes stores of catecholemines in neurons.
Use: HTN, usually combined with other drugs.
S.E.- Decreased total peripheral resistance (TPR), decreased cardiac output, sedation, DEPRESSION, increased GI motility, nasal stuffiness.
Trimethaphan (Arfonad)
MOA: Ganglionic blocker-blocks sympathetic and parasympathetic outflow at ganglia.
Notes: Used ONLY for HTN Crisis when all else fails; used during surgery to decrease bleeding; hospital use only.
Guanethidine (Ismelin)
MOA: Enters nerve terminals, displacing NE so less is released.
Notes: Drug of LAST CHOICE; causes severe postural hypotension (decreased blood pressure when standing, can faint); patient can't stand up due to venous pooling.