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7 Cards in this Set
- Front
- Back
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Digoxin (Lanoxin)
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Class: Cardiac glycoside
Use: Treatment for Congestive Heart Failure (CHF) MOA: Inhibits the Na-K ATPase (Sodium/Potassium Pump)of cardiac muscle cells. Increases cardiac contractility, decreases Heart Rate and AV nodal conduction. |
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Digitoxin (Crystodigin)
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Class: Cardiac glycoside
Use: Treatment for Congestive Heart Failure (CHF) MOA: Inhibits the Na-K ATPase (Sodium/Potassium Pump)of cardiac muscle cells. Increases cardiac contractility, decreases Heart Rate and AV nodal conduction. |
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Clonidine (Catapres)
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Centrally - Acting Sympathetic Agonist
Receptor: Alpha 2 Agonist MOA: Turns off NE release in the brain. Uses: HTN S.E.- Vasodilation, decreased HR, Decreased BP, sedation, dry mouth, nasal stuffiness, constipation, edema. Notes: DO NOT d/c abruptly (causes rebound HTN). Take at night due to sedation. |
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Methyldopa (Aldomet)
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Centrally - Acting Sympathetic Agonist
Receptor: Alpha 2 Agonist MOA: Turns off NE release in the brain. Uses: HTN S.E.- Vasodilation, decreased HR, Decreased BP, sedation, dry mouth, nasal stuffiness, edema. Notes: DO NOT d/c abruptly (causes rebound HTN). Take at night due to sedation. |
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Reserpine(Serpasil)
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Peripherally-Acting Sympathetic Agonist
MOA: Depletes stores of catecholemines in neurons. Use: HTN, usually combined with other drugs. S.E.- Decreased total peripheral resistance (TPR), decreased cardiac output, sedation, DEPRESSION, increased GI motility, nasal stuffiness. |
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Trimethaphan (Arfonad)
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MOA: Ganglionic blocker-blocks sympathetic and parasympathetic outflow at ganglia.
Notes: Used ONLY for HTN Crisis when all else fails; used during surgery to decrease bleeding; hospital use only. |
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Guanethidine (Ismelin)
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MOA: Enters nerve terminals, displacing NE so less is released.
Notes: Drug of LAST CHOICE; causes severe postural hypotension (decreased blood pressure when standing, can faint); patient can't stand up due to venous pooling. |
