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22 Cards in this Set
- Front
- Back
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Drugs for angina help correct the imbalance by...
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1. decreasing the oxygen demand
2. increasing the oxygen supply |
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drug therapy for angina pectoris decreases
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demand for oxygen
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drug therapy for variant (Prinzmetal's) angina increases
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supply of oxygen
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What are the 5 groups of drug therapy for angina?
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1.aspirin
2.cholesterol reducing agents 3.nitrates 4.betablockers 5.calcium channel blockers |
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Beta blockers
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-b1 and b2 antagonists
-block the physiological responses to norepi and epi -decrease three major determinants of myocardial oxygen demand |
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what is the beta-blocker of choice?
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propanolol
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what are the three major determinants of myocardial oxygen demand
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1. heart rate
2. contractility 3. systolic wall tension |
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therapeutic use of beta blockers...
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-angina pectoris
-post MI |
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what drug is contraindicated for use in pts with variant (Prinzemetal's) angina?
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beta blockers (propanolol)
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adverse effects of beta blockers
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-Tiredness /fatigue
-Lethargy -Impotence -Bradycardia -Bronchospasm |
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What are three examples of nitrovasodilators?
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-Nitroglycerin
-Isosorbide Dinitrate -Amyl Nitrate |
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How do nitrovasodilators work?
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The nitrovasodilators relax almost all smooth muscle by releasing NO which then stimulates the release of cGMP
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nitroglycerin is used for
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both angina pectoris and variant angina
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Important things about nitro
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-tolerance develops rapidly
-undergoes extensive 1st pass metabolism -evokes stimulation of sympathetic nervous system -may cause tachycardia or "steeling effect" |
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side effects of nitroglycerin
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1. headaches
2. syncope (fainting) |
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4 types of calcium channel blockers
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1.diltiazem
2.nifedipine 3.verapamil 4.bepridil |
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Calcium channel blockers...
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prevent calcium influx into myocytes and smooth muscle lining arteries and atrerioles by blocking the voltage dependent L-Type calcium channel
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diltiazem and verapamil also
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reduce heart rate
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bepridil also
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has action to block fast sodium channels
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Uses of calcium channel blockers
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angina pectoris
variant angina Hypertension; arrhythmias; subarachnoid hemorrhage |
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side effects of calcium channel blockers
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Ankle edema
Headache Flushing Palpitation |
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important things about antiplatlet agents and angina
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The formation of platelet aggregates are important in the pathogenesis of angina, unstable angina and acute MI
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