Pharmacology Exam 1

Front 1

Tamoxifen

Back 1

(Nolvadex)

First SERM to be widely used. By blocking estrogen receptors it can inhibit cell growth in the breast. Thus used to treat breast cancer. Protects against osteoporosis and favorable effect on serum lipids. Increases risk of endometrial cancer and thromboembolism.

Front 2

Raloxifene

Back 2

(Evista)

Protects against breast cancer and osteoporosis. Promotes thromboembolism and induces hot flashes. Does not activate estrogen receptors in the endometrium, so does not pose risk of uterine cancer.

Front 3

Mifespristone

Back 3

(Mifeprex)

Can prevent pregnancy or cause abortion. If taken within 5 days of unprotected sex it will prevent pregnancy from occurring or if taken after will terminate pregnancy that has already begun.

Front 4

Misoprostol

Back 4

(Cytotec)

Used to induce labor.

Front 5

Clomiphene

Back 5

(Clomid)

Promotes follicular maturation and ovulation by promoting release of FSH and LH from the pituitary gland, somtimes induction of ovulation requires co-treatment with hCG.

Front 6

Menotropins

Back 6

(Repronex)

Act directly on the ovary to promote follicular development. After follicles have matured, hCG is given to induce ovulation.

Front 7

Terbutaline

Back 7

(Brethine)

Delay of preterm labor.

Front 8

Nifedipine

Back 8

(Adalat)

Delay of preterm labor.

Front 9

Hydroxyprogesterone caporate

Back 9

(Makena)

Reduces risk of preterm labor. Mechanism underlying prevention of preterm birth is unknown.

Front 10

Oxytocin

Back 10

(Pitocin)

Hormone promotes uterine contraction during partition and stimulates the milk ejection reflex. Drug of choice for stopping postpartum bleeding.

Front 11

Tranexamic acid

Back 11

(Lysteda)

First nonhormonal product for oral therapy of cyclic heavy menstrual bleeding. Inhibits plasmid the enzyme that dissolves the fibrin mesh work of blood clots

Front 12

Finasteride

Back 12

(Proscar)

Treatment reduces levels of DHT in blood by 70% (but does not decrease testosterone levels). By decreasing DHT availability, finasteride promotes regression of prostate epithelial tissue, and thereby decreases mechanical obstruction of the urethra.

Front 13

Tamsulosin

Back 13

(Flomax)

Blockade of alpha receptors relaxes smooth muscle in the bladder neck prostate capsule, and prostatic urethra, thereby decreasing dynamic obstruction of the urethra.