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127 Cards in this Set

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Morphine Sulfate IV
Onset: Rapid
Peak: 20 min
Duration: 4-5 hr
Half Life: 2-4 hr
Met: Liver EXC: Renal
Meperdine IM
Onset: 10 - 15 min
Peak: 30 - 50 min
Duration: 2-4 hr
Half Life: 2.5-4 hr
Met: Liver EXC: Renal
Oxycodone PO
Onset: 10 - 15 min
Peak: 60-90 min
Duration: 3-6 hr
Half Life: 2-3 hr
Met: Liver
Fentanyl Patch
Onset: 6 hr
Peak: 12 - 24 hr
Duration: 72 hr while worn
Half Life: 17 hr
Met: Liver EXC: Renal
Naloxone IV
Onset: 1-2 hr
Peak: unknown
Duration: 45 min
Half Life: 60-90 min
Met: Liver
Percocet PO
Onset: 10 - 15 min
Peak: 60-90 min
Duration: 3-6 hr
Half Life: 2-3 hr
Met: Liver
Vicodin ES PO
Onset: 10 - 30 min
Peak: 30 - 60 min
Duration: 4-6 hr
Half Life: 2.2 hr
Met: Liver EXC: Renal
Acetaminophen PO
Onset: 0.5 - 1 hr
Peak: 1-3 hr
Duration: 3-8 hr
Half Life:1-3 hr
Met: Liver EXC: Renal
Corticotropin
Indications:Stimulation of the release of cortisol from the adrenal cortex. Treatment of multiple sclerosis and corticotropin insufficiency caused by long term corticosteroid use.
Side Effects:CNS - convulsions, dizziness, euphoria, insomnia, headache, depression, psychosis. GI- N/V, peptic ulcer perforation, pancreatitis. GU- Water and Na retention, hypokalemia. Other: sweating, acne, hyperpigmentation, weakness, muscle atrophy, myalgia, arthralgia
N Implications: VS, F&E values, BG levels, Chest x ray, CBC, I&O, wt., Cortisol level, allergy to pork b/c of cross-sensitivities
Other: Used to dx. adrenocortical insufficiency
Somatotropin
somatrem
Indications: Growth failure; AIDS- related wasting syndrome
Side Effects: Nervous-headache, Endocrine- hyperglycemia, ketosis, hypothyroidism, GU- hypercalciuria, Other - rash, uticaria, antibodies to GH, inflammation at injection site.
N Implications: Thyroid Function studies, HG antibodies
Other: Should increase growth in children
Octretide
sandostatin
Indications: Acromegally, metastatic carcinoid tumors, VIPomas
Side Effects: s/s of carcinoid tumors stemming from the secretion of VIP
N Implications: wt, I&O, monitor flushing and F&E loss, decrease plasma concentrations of VIP
Desmopressin
Vasopressin
Indications: Primary nocturnal enuresis, central cranial DI, hemophilia A & type 1 von Willebrand's disease
Side Effects:CV- increase P, Nervous - drowsiness, headache, lethargy, flushing, GI - N, heartburn, cramps, GU - uterine cramping Other - Nasal irritation & congestion, tremor, sweating, vertigo
N Implications: ortho BP, CBC, Cardiac enzymes, wt, ECG, Pulse, VS, I&O, wt, edema
Other: similar to ADH
Peak
Highest blood level
Differs per class, generally 1 hour after giving the rx
Trough
Lowest blood level
Generally drawn 30 min prior to administering the medication
Assessment
Data collection (subj, obj)
Medication Hx
New meds are more important to teach about. Document everything even pt teaching.
Nursing Diagnosis
3 steps - actual or risk of response to illness; related to; as evidenced by.
Usually refers back to admitting dx, included as an intervention.
Planning, Goals, Outcomes
Must be specific and measurable, pt centered, give a time frame (specified), realistic.
Priortize
Implementation
Follow 6 rights of medication administration.
6 Rights of Medication Administration
* Right Drug
* Right Dose
* Right Time
* Right Route
* Right Patient
* Right Documentation
Evaluation
Monitoring the patient's response to drug therapy (expected and unexpected)
Number 0 - 10, body lang, facial expression, vital sign, explain feelings.
Hepatotoxicity
Toxicity in Liver
Nephrotoxicity
Toxicity in Kidneys
Age considerations
Older patients are at a greater risk for toxicity due to slower metabolism and excretion. Children are also susceptible due to differences in body weight.
First Pass Effect
The metabolism of a drug & its passage from the liver into the circulation
Only enteral routes have first pass effect. Not IM, IV, Topical, SL or SQ
Metabolism
Most drugs are metabolized in the liver, some by the skeletal muscle, kidneys, lungs, plasma or intestinal mucosa
Factors that decrease Metabolism
Cardiovascular dysfunction
Renal insufficiency
Starvation
Obstructive jaundice
Slow acetylator
Erythromycin or ketoconazole drug therapy
Results of delaying Metabolism
Accumulation of drugs
Prolonged action of the drugs  drug toxicity
Stimulating drug metabolism causes:
Diminished pharmacologic effects
Excretion
Mainly from the Kidneys but also the Liver and Bowel
Half life
The time it takes for one half (50%) of the original amount of a drug to be removed from the body
BUN and Creatnine, usually calculated by pharmacist. Nurse makes sure the dosage is correct.
Drug Movement
Onset: The time it takes for the drug to elicit a therapeutic response
Peak: The time it takes for a drug to reach its maximum therapeutic response
Duration: The time concentration is sufficient to elicit a therapeutic response
Very Important with insulin to time feeding and testing.
The Elderly
General Considerations
Elderly: older than age 65
Use of over-the-counter medications
Increased incidence of chronic illnesses
Sensory and motor deficits
Polypharmacy
The Elderly
Physiologic Changes
Cardiovascular
Gastrointestinal
Hepatic
Renal
Cutlural Considerations
Expression of pain differs. Beliefs towards health care. Respect prayer times and religious practices. Document, Document, Document
Outcomes
When something happens that is not suppose to. Side effects are known expected outcomes, Adverse reactions are unexpected and unwanted such as shortness of breath. Allergic reactions can be swelling, itching, hives. Anaphlactic response can be life threatening, a systemic allergic response such as the throat closes. Idiosyncratic reaction is the opposite effect than what is expected.
Teaching Assessment
What does the patient know? Build on that.
Learning Session
Make sure you see a return demonstration before they are discharged. Do not use a family member to translate.
Analgesics
Medications that relieves pain without causing loss of consciousness
“Painkillers”
Opioids
NSAIDs
Tolerance
The amount of pain a person can endure without it interfering with normal function
Acute Pain
Sudden onset
Usually subsides once treated
Chronic Pain
Persistent or recurring
Lasts 3 to 6 months
Often difficult to treat
Somatic Pain
Pain that originates from skeletal muscles, ligaments, or joints
Vascular Pain
Pain that originates from a pathology of the vascular or perivascular tissues
Visceral Pain
Pain that originates from organs or smooth muscles.
using a PCA
Monitor respiratory status, educate won’t become addicted if in pain from surgery, takes a long time to develop an opioid tolerance. Can not use placebos, this is illegal and unethical.
Adjuvant Drugs
Assist primary drugs in relieving pain
NSAIDs
Antidepressants
Anticonvulsants
Corticosteroids
Work with the primary medication to enhance it’s effects. Synergistic affect is achieved using adjuvant drugs.
Ceiling Effect
Once a drug reaches a maximum analgesic effect and higher doses do not work, change the medication
Agonists
Bind to an opioid pain receptor (brain)
Cause an analgesic response (reduction of pain sensation)
Helps
Agonists-Antagonists
Bind to a pain receptor
Cause a weaker neurologic response than a full agonist
Also called partial agonist or mixed agonist
Antagonists
Reverse the effects of these drugs on pain receptors
Bind to a pain receptor and exert no response
Also known as competitive antagonists
Indications of Analgesics
Main: to alleviate moderate to severe pain
Often given with adjuvant analgesic drugs to assist primary drugs with pain relief
Opioids are also used for:
Cough center suppression
Treatment of diarrhea
Balanced anesthesia
Contraindications for Analgesics
Known drug allergy
Severe asthma
Use with extreme caution if:
Respiratory insufficiency
Elevated intracranial pressure
Morbid obesity
Sleep apnea
Paralytic ileus
Adverse Effects of Analgesics
Euphoria
CNS depression
Leads to respiratory depression
Most serious adverse effect
Nausea and vomiting
Urinary retention
Diaphoresis and flushing
Pupil constriction (miosis)
Constipation
Itching
Nursing Management
When administering narcotics Always make sure Narcan is on the floor!!!! Think safety, monitor breathing.
Non-opioid Analgesics
Acetaminophen
Analgesic and antipyretic effects
Little to no anti-inflammatory effects
Available over the counter and in combination products with opioids
Mechanism of Action
Similar to salicylates
Blocks pain impulses peripherally by inhibiting prostaglandin synthesis
Indications
Mild to moderate pain
Fever
Alternative for those who cannot take aspirin products
Tylenol Interactions
Dangerous interactions may occur if taken with alcohol or other drugs that are hepatotoxic
Should not be taken in the presence of
Drug allergy
Liver dysfunction
Possible liver failure
G-6-PD deficiency
Tylenol Overdose
Hepatotoxic
Recommended antidote: acetylcysteine
Rotten egg smell (disguise the flavor)
Given in a 30 mL medicine cup
Repeated dose as ordered (1 hr)
Vomiting (r/t smell &/or ingestion)
Nursing Care: Analgesics
Obtain a thorough history (allergies, use of alcohol) VS, I&O, and pain assessment
Nursing Care: Opioids
Taken with food, think safety, prevent injuries, Check dosages carefully. Withhold if decline in pt condition, abnormal VS, or RR <10-12 breaths per minute
Posterior Pituitary
Vasopressin
Anterior Pituitary
Somatotropin
Cosyntropin (Cortrosyn)
Stimulates release of cortisol from adrenal cortex
Antiinflammatory effect
Promotes renal retention of sodium Given to Addison patients. Monitor for HTN, Edema, s/s of Cushings. Teach to drink a lot of water and to avoid all vaccines. At risk for infection.
SOMATROPIN & SOMATREM
GH (Growth Hormone)
Stimulate skeletal growth in patients with deficient GH
hypopituitary dwarfism doesn’t solve problem but helps with the deficiency.
Octreotide (SANDOSTATIN)
Anterior pituitary medication. Throws off glucose so monitor BG more frequently.
VASOPRESSIN & DESMOPRESSIN
Posterior pituitary – SIADH – specific gravity should increase. 90/60 – 135/80 is good if on vasopressin.
Vasopressin
Vasoconstrictor
Vasopressin (vasoconstrictor)
hypotensive emergencies
GI bleeding
pulseless cardiac arrest
Desmopressin
Used for dose-dependent treatment of blood disorders
used for nocturnal enuresis
Administration Education
Always rotate the site for absorption purposes. Educate pt to rotate by teaching them the different sites and relate them to times of day, make a diagram with colors, or rotate per days of the week. Taper off all hormones.
Thyroid Medication
levothyroxine (Synthroid, Levothyroid)
Given for hypothyroidism or after surgery. Give early in morning so can work all day and to prevent insomnia.
Synthroid Adverse Effects
Cardiac Dysrhythmia Monitor TSH level every 3 weeks to ensure patient is getting the correct dosage. DO NOT skip a dosage. Monitor BG, increased healing time, Large complication is cardiac arrhythmias which will also cause respiratory issues. s/s of hyperthyroidism.
Nursing Care with Synthroid
Check for allergies to iodine or shellfish. Continue Synthroid if pregnant even though there is a small chance of fetal retardation. Let pt know that it takes 2 – 3 weeks to start feeling better.
TSH Levels
TSH should be 0.4 – 4.5
Check every 4 weeks
Alert nurse if pt has more activity tolerance, BP increases to normal, Adverse = heart racing, palpitations, insomnia, exopthalamos, s/s of hyper.
Adrenal glands
Medulla = epi and norepi
Cortex = (Sugar, Salt and Sex) Glucocorticoids, Mineralcorticoids (aldosterone), Sex hormones
Corticoid Steroid Indications
Adrenocortical deficiency
Exacerbations of chronic respiratory illnesses, such as asthma and COPD
Organ transplant (decrease immune response)
Corticoid Steroid Contraindications
Drug allergies
Serious infections
patients with
Gastritis, reflux disease, ulcer disease
Diabetes
Cardiac/renal/liver dysfunction
Corticoid Steroid Adverse Effects
Monitor K and Na levels. S/s of Cushings, GI and Cardiac symptoms. “Steroid Psychosis” very common – puffy look, retaining water, mood changes, moody quickly. Taper up and down to adjust dosages.
Makes skin paper thin.
Given oral, IM but never SQ. Must be taken with food.
Insulin
Substitute for the endogenous hormone
Restores the diabetic patient’s ability to:
Metabolize carbohydrates, fats, and proteins
Store glucose in the liver
Convert glycogen to fat stores
Rapid Acting Insulin
Give SQ not IV. lispro (Humalog), aspart (NovoLog), glulisine (Apidra).
Quickest
Short Acting Insulin
Regular insulin (Humulin R)
Onset 30 to 60 minutes
The only insulin product that can be given by IV bolus, IV infusion, or even IM
Intermediate-acting Insulin
Isophane insulin suspension (also called NPH)
Cloudy appearance
Slower in onset and more prolonged in duration than endogenous insulin
Long Acting Insulin
glargine (Lantus), detemir (Levemir)
Clear, colorless solution
Referred to as basal insulin
Combination Insulin Products
NPH 70% and regular insulin 30% (Humulin 70/30, Novolin 70/30, Novolog 70/30)
NPH 50% and regular insulin 50% (Humulin 50/50)
Sliding Scale
SC short-acting or regular insulin doses adjusted according to blood glucose test results
Typically used in hospitalized diabetic patients or those on TPN or enteral tube feedings
Subcutaneous insulin is ordered in an amount that increases as the blood glucose increases
Disadvantage: delays insulin administration until hyperglycemia occurs; results in large swings in glucose control
Oral Anti-Diabetic Drugs
Used for type 2 diabetes
Lifestyle modifications
Diet, exercise, smoking cessation, weight loss
Oral antidiabetic drugs may not be effective unless the patient also makes behavioral or lifestyle change
Used alone or in combination with other drugs and/or diet and lifestyle changes to lower the blood glucose levels in patients with type 2 diabetes
Biguanides
Metformin (Glucophage)
Decrease production of glucose by the liver
Decrease intestinal absorption of glucose
Increase uptake of glucose by tissues
Do not increase insulin secretion from the pancreas (does not cause hypoglycemia)
Side Effects of Glucophage
abdominal bloating, nausea, cramping, diarrhea, feeling of fullness
May also cause metallic taste, reduced vitamin B12 levels
Lactic acidosis is rare but lethal if it occurs
Does not cause hypoglycemia
Sulfonylureas
chlorpropamide (Diabinese), tolazamide (Tolinase)
glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase)

Stimulate insulin secretion from the beta cells of the pancreas, thus increasing insulin levels
Beta cell function must be present
Improve sensitivity to insulin in tissues
Result in lower blood glucose levels
Work in the pancreas.
Sulfonylureas: Drug Interactions
hypoglycemic effect increases when taken with alcohol, anabolic steroids, allergic cross-sensitivity may occur with loop diuretics and sulfonamide antibiotics
Adrenergics, corticosteroids, thiazides, others may reduce hypoglycemic effects
May interact with alcohol, causing a disulfiram-type reaction
Need to eat their breakfast when they take this.
Side Effects of Sulfonylureas
Hypoglycemia
Hematologic effects
Nausea, epigastric fullness
Heartburn
Glinides
repaglinide (Prandin), nateglinide (Starlix)
Action similar to sulfonylureas
Increase insulin secretion from the pancreas
Prandin is taken only once a day in the mornings. Must take while eating not prior to.
Glucose is fighting with insulin.
Thiazolidinediones (glitazones)
pioglitazone (Actos), rosiglitazone (Avandia)
Decrease insulin resistance
“Insulin sensitizing drugs”
Increase glucose uptake and use in skeletal muscle
Inhibit glucose and triglyceride production in the liver
Glinides Side Effects
Headache, hypoglycemic effects, dizziness, weight gain, joint pain, upper respiratory infection or flulike symptoms
Thiazolidinediones Side Effects
Moderate weight gain, edema, mild anemia
Hepatic toxicity—monitor ALT levels
Alpha-Glucosidase Inhibitors
aacarbose (Precose), miglitol (Glyset)
Delays absorption of glucose. Does not cause hypoglycemia. Take with first bite of meal.
Accarbose
Route: PO
Onset: 1-1.5 hr
Peak:2 hr
Half Life:2-3 hr
Duration: unknown
Glipizide
Route: PO
Onset: 1hr
Peak:1-3 hr
Half Life:2-5 hr
Duration:6-8 hr
Metformin
Route: PO
Onset: < 1 hr
Peak:1-3 hr
Half Life:1.5-5 hr
Duration:24 hr
Actos
Route: PO
Onset: Delayed
Peak: 2 hr
Half Life:3-7 hr
Duration:Unknown
Prandin
Route: PO
Onset: 15-60 min
Peak:1 hr
Half Life:2-3 hr
Duration:4-6 hr
Nursing Care with Diabetes
Diet is most important with Type 2. H A1c should be less than 6%. If NPO and BG is 350 in am give insulin. Recheck BG pt should always have IV fluids going. If pt is 120 you could probably hold the insulin until after the surgery.
Education with Diabetes
Educate even if they have been diabetic for years. Don’t adjust based on how you feel. How to take the insulin properly. Diabetic educators are available at the hospital. Use lancets and needles only once.
Nursing Care with Insulin
Check blood glucose level before giving insulin
Roll vials between hands instead of shaking them to mix suspensions
Ensure correct storage of insulin vials
ONLY use insulin syringes, calibrated in units, to measure and give insulin
Ensure correct timing of insulin dose with meals
Hypoglycemia
If the patient is conscious, give oral form of glucose
Give the patient glucose tablets or gel, corn syrup, honey, fruit juice, or nondiet soft drink or have the patient eat a small snack such as crackers or a half sandwich
If the patient is unconscious, give D50W or glucagon, intravenously
Parietal Cells
Produce & secrete HCl (Histamine)
Primary site of action for many acid-controller drugs
Helicobacter pylori
Tx: Biaxin (Clarithromycin)H Pylori can lead to stomach cancer after eating away at the lining the cells change increasing the risk.
(TUMs)
Antacids
Neutralizes stomach acid and promotes gastric mucosal defense. Buffers the acidic properties of Hcl. DO NOT prevent overproduction of acid. DO NOT neutralize the acid once it is in the stomach.
Anti-acids (antacids) Effects
Palliative Only!! Reduction of pain, neutralizes pH. Renal patients should not take antacids due to renal calculi, and increased calcium.
Aluminum Salts
Constipating Often recommended for patients with renal disease (more easily excreted)
Basaljel, Maalox, Mylanta, Gaviscon,
Magnesium Salts
Diarrhea (side effect)
Milk of Magnesia
Dangerous when used with renal failure
Combination products such as Maalox, Mylanta (aluminum and magnesium)
Calcium Salts
Carbonate is most common (TUMs) May cause constipation, kidney stones
Sodium Bicarbonate
Buffers. Quick onset, short duration. May cause metabolic alkalosis
Monitor the ph, CO2,HCO3 levels
Sodium content may cause problems in patients with HF, hypertension, or renal insufficiency
Antiflatulents
Simethicone (Mylicon)
used to relieve the painful symptoms associated with gas
Nursing Guidelines for Antacids
Assess for allergies, Fluid imbalances
Renal disease
GI obstruction
Heart failure (HF) &/or Hypertension
Pregnancy
Patients with HF or hypertension should not use antacids with high sodium content
Administration of Antacids
Most medications should be given 1-2 hours after giving an antacid
Chewable tablets are chewed thoroughly
Liquid forms are shaken well before giving
Administer with at least 6-8 oz of water to enhance absorption
H2 Blockers
Reduce acid secretion by Block histamine at the (H2) receptors of acid-producing parietal cells. cimetidine (Tagamet)
nizatidine (Axid)
famotidine (Pepcid) or Pepcid AC
ranitidine (Zantac). Used to treat GERD, PUD, Erosive esophagitis
H2 Blockers adverse effects
Cimetidine may induce impotence and gynecomastia
Extreme Cases: May cause headaches, lethargy, confusion, diarrhea, urticaria, sweating, flushing, other effects
Smoking has been shown to decrease the effectiveness of H2 blockers (Patient Education)
Administration of H2 Blockers
Pepcid can be given IV in the hospital if the pt is NPO or has dysphagia.
Take 1 hour before or after antacids
Proton Pump Inhibitors
Stops the Pumps from working.Inhibits pump from allowing the secretions to be used. End in prazole
lansoprazole (Prevacid)
omeprazole (Prilosec)*
rabeprazole (AcipHex)
pantoprazole (Protonix)
(IV form available)
esomeprazole (Nexium)
PPI Nursing Care
May increase serum levels of diazepam and phenytoin; may increase chance for bleeding with warfarin
The granules of pantoprazole capsules may be given via NG tubes, but the NG tube must be at least 16 g or the tube may become clogged
Capsule contents may be opened and mixed with apple juice, but do not chew or crush delayed-release granules
Proton pump inhibitors often work best when taken 30 to 60 minutes before meals
Sucracalfate (Carafate)
Used for stress ulcers, peptic ulcer disease
Does not stop the acid production!
May impair absorption of other drugs—give other drugs at least 2 hours before sucralfate
H2 and Carafate work together to decrease the secretions and line the stomach.
Antinausea and Antiemetics
Timing is important for effectiveness.
Anticholinergics
Bind to and block acetylcholine (ACh) receptors in the inner ear labyrinth
Scopolamine (Trans-derm SCOP)
Also used for motion sickness (transdermal patch) Place patch behind ear at least 4 hours before you incur motion. Change every 3 days or if it gets wet.
Antihistamine (H1 Blockers)
Prevent cholinergic stimulation in vestibular & reticular areas, thus preventing nausea and vomiting
Used for motion sickness, nonproductive cough, allergy symptoms, sedation
Examples
dimenhydrinate (Dramamine)
diphenhydramine (Benadryl)
meclizine (Antivert)
Antidopaminergics
Blocks dopamine prochlorperazine (Compazine)
-> Adverse Reactions: may cause Parkinson-like clinical manifestations; extra-pyramidal (involuntary movements, facial grimacing, hand trembling)
promethazine (Phenergan)
droperidol (Inapsine)
Use is controversial r/t cardiac dysrhythmia
Prokinetics
Cause CTZ to be desensitized to impulses it receives from the GI tract
Also stimulate peristalsis in GI tract, enhancing emptying of stomach contents. Also used for GERD, delayed gastric emptying
Examples: metoclopramide (Reglan)
Serotonin Blockers
Used for nausea and vomiting in patients receiving chemotherapy & for postoperative nausea and vomiting
Examples:
dolasetron (Anzemet)
palonosetron (Aloxi)
granisetron (Kytril)
ondansetron (Zofran)
Tetrahydrocannabinoids
Alter mood and body’s perception of its surroundings
Example:
dronabinol (Marinol)
Used for nausea and vomiting associated with chemotherapy, and anorexia associated with weight loss in AIDS patients
Stimulates appetite
Homeopathic: Ginger
Adverse effects
anorexia, nausea, & vomiting (smell), skin reactions
Don’t give warfarin or coumadin if taking Ginger. May interact causing bleeding.