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6 Cards in this Set
- Front
- Back
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The most important site for metabolism is
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the liver
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What is Phase 1?
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reactions modify the drug molecule by oxidation, reduction or hydrolysis
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What is Phase 2?
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reactions are synthetic; they involve the addition of new chemical groups
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Oxidation reaction
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Drug + NADPH + H+ + O2 => Drug-OH + NADP+ + H2O
Drug-OX => Drug-OH + XOH |
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Oxidation reactions are catalyzed by?
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superfamily of enzymes known as the cytochromes P450 (CYPs)
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What is the most important phase 2?
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glucuronidation
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