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19 Cards in this Set
- Front
- Back
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Lispro
-Mechanism |
Short-Acting Insulin
A) Binds Insulin receptor (Tyrosine Kinase Activity) B) Liver: Increase glucose stored as glycogen C)Muscule: Increases glycogen and protein synthesis; K+ uptake Fat: aids TG storage |
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Aspart
-Mechanism |
Short-Acting Insulin
A) Binds Insulin receptor (Tyrosine Kinase Activity) B) Liver: Increase glucose stored as glycogen C)Muscle: Increases glycogen and protein synthesis; K+ uptake Fat: aids TG storage |
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Regular
-Mechanism |
Short-Acting Insulin
A) Binds Insulin receptor (Tyrosine Kinase Activity) B) Liver: Increase glucose stored as glycogen C)Muscule: Increases glycogen and protein synthesis; K+ uptake Fat: aids TG storage |
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NPH
-Mechanism |
Intermediate-Acting Insulin
A) Binds Insulin receptor (Tyrosine Kinase Activity) B) Liver: Increase glucose stored as glycogen C)Muscle: Increases glycogen and protein synthesis; K+ uptake Fat: aids TG storage |
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Glargine
-Mechanism |
Long-acting
A) Binds Insulin receptor (Tyrosine Kinase Activity) B) Liver: Increase glucose stored as glycogen C)Muscule: Increases glycogen and protein synthesis; K+ uptake Fat: aids TG storage |
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Detemir
-Mechanism |
Long-Acting Insulin
A) Binds Insulin receptor (Tyrosine Kinase Activity) B) Liver: Increase glucose stored as glycogen C)Muscule: Increases glycogen and protein synthesis; K+ uptake Fat: aids TG storage |
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What other use is Insulin drug used for?
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Hyperglycemia (stress-induced) and hyperkalemia (K+ follows insulin inside cell)
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Toxicity of insulin
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Hypoglycemia
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Glyburide
-Mechanism |
Sulfonylurea (also Glipizide)
A)Closes K+ channel in Beta-cell membrane so cell depolarizes which triggers insulin release via calcium influx B)need some cells to work to trigger the insulin release so only for type II |
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Glipizide
-Side effects |
Sulfyonylurea same as Glyburide so Hypoglycemia
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Metformin
-Mechanism |
Biguanide Acts as an insulin sensitizer so oral hypoglycemic possibly done by decreasing gluconeogenesis
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Side effects of Metformin
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Biguanide side effect is Lactic acidosis (Can be grave) don't use also if person is renal insufficient
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Thiazolidenide
-Mechanism |
Glitazones (all drugs end in this)
Increases target cell response to Insulin (very similar to exercise) |
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Glitazones
-Side effects |
Weight gain, edema, Hepatotoxicity, and CV toxicity
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Acarbose
-Mechanism |
Alpha-glucosidase inhibitor (so is migitol)
A) inhibits interstinal brush broder alpha-glucosidase Delayed sugar hydrolysis and glucose absorption lead to decrease postprandial hyperglycemia |
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Migitol is what type of drug
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Alpha-Glucosidase inhibitor
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Pramlintide
Mechanism |
Decrease glucagon
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Exenatide
-Mechanism |
GLP-1 Mimetics
A) Increase insulin and decreases glucagon release |
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Exenatide
-Side Effects |
Increase satiety so might be used for weight loss but also increase pancreatitis
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