Pharmacology Defintions

Front 1

• Pharmacology

Back 1

the study of the interaction or biological activity of drugs. medications chemical with people

Front 2

• Affinity

Back 2

attraction for, tendency to combine with

Front 3

• Agonist-

Back 3

drug that combines with a receptor & you get a pharmacological effect

Front 4

• Anaphylaxis-

Back 4

antigen –antibody reaction, edema and shock, release of toxic substances by the body

Front 5

• Antagonist

Back 5

- drug that opposes the action of an agonist

Front 6

• Efficacy

Back 6

maximum therapeutic effect attainable by a drug

Front 7

• Parental-

Back 7

by various routes of injection

Front 8

• Pharmacodynamics

Back 8

drugs effects & the handling of drugs by the body

Front 9

• Pharmacokinetics

Back 9

includes the absorption, distribution, breakdown and elimination of drugs in the body

Front 10

• Synergism-

Back 10

combined effect with drugs resulting in a greater effect than if individually given

Front 11

• Tachyphylaxis

Back 11

rapid decrease response following repeated doses

Front 12

• Therapeutic index

Back 12

ratio of lethal dose to effective dose

Front 13

• Tolerance-

Back 13

decrease pharmacological response to a drug on a repeated administration.

Front 14

• Chemical-

Back 14

indicated the drug’s chemical structure

Front 15

• Code

Back 15

name assigned by a manuf. To an experimental chemical that may become a drug

Front 16

• Generic

Back 16

assigned by the US adopted name council when the chemical appears to have therapeutic use

Front 17

• Official-

Back 17

when approved for use, generic name becomes official

Front 18

• Trade, brand, or proprietary

Back 18

given by the manuf

Front 19

• Oral

Back 19

most common, safest convenient economical, slower method to achieve desired effect

Front 20

• Intradermal

Back 20

upper layers of the slow, very slow absorption

Front 21

• Subcutaneous

Back 21

slow absorption, lack of vasculature.

Front 22

• Intramuscular

Back 22

into muscle mass absorption, faster than sub-q

Front 23

• Intravenous

Back 23

fastest method of delivery directly into vein by injection or infusion.

Front 24

• Inhalation

Back 24

second only to IV in speed.

Front 25

• Distribution-

Back 25

circulation of drug in blood stream & transport across cell membranes.

Front 26

• Biotransformation

Back 26

metabolic changes in a drug

Front 27

• Passive transfer

Back 27

drugs enter cell membrane through pored & more permeable to non-inoized drugs

Front 28

• Specialized transport- active transport

Back 28

carrier involved requires special energy from a drug molecule complex of surface cell brings in drug

Front 29

• Synthetic

Back 29

coupling or conjugating, involved the union of the drug or its metabolite with another substance

Front 30

• Nonsynthetic-

Back 30

3 mechanisms that change the activity or inactivity of the drug.

Front 31

Two current theories of a drug receptor site

Back 31

• Lock & Key- molecularly you have a chemical match or structural specificity.
• Non Structurally specific- hypnotics deposit in or on surface of cell or membranes (ex. Anesthetics)

Front 32

4 factors and their variables that affect drug distribution

Back 32

•Absorption
•Passage of drugs across body membranes distribution
•Biotransformation
•Excretion

Front 33

what type of effect does inhaltion provide

Back 33

systemic, and highly vascularized

Front 34

what is another name for a syntheic drug

Back 34

metabolite