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20 Cards in this Set
- Front
- Back
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What is the term used for the measure of the concentration of drug needed to elicit a given effect.
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Potency
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The concentration which produces 50% of the maximum response is often referred to as
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EC50
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The (larger/smaller) number of EC50 the more potent the drug is
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smaller
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What is the term for the measure of the ability of a drug to elict a response when it occupies a receptor?
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Intrinsic efficacy
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What has no intrinsic efficacy?
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antagonist
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A full agonist is a drug that is able to elicit a _________ response from the system being studied
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maximum
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What is the intrinsic efficacy of a full agonist?
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1
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What is the intrinsic efficacy of a partial agonist?
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ratio of the maximum response
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The response of a tissue depends on 2 factors
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1. Intrinsic efficacy
2. Affinity of the drug for the receptor |
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What is the formula to calculate the dissociation constant for the drug-receptor complex
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Rate constant for the reverse reaction/ rate constant for the forward reaction
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The drug-receptor complex dissociation constant Kd is a measure of...
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the affinity of a drug for the receptor
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If 2 drugs, 1 with a Kd of 10-6 and 1 with a Kd of 10-9 which is more strongly bounded to the receptor
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10-9
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The (larger/smaller) the Kd the higher the affinity
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smaller
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What is the term for the ability to convert a drug-induced stimulus into a response?
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transducer function
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The maximum response of a system to an agonist depends only on the.....
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intrinsic efficacy
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What type of antagonist competes with the agonist for occupation of the receptor or target molecule
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Competitive
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Competitive antagonism may be (surmountable/insurmountable)
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both
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Reversible competitive antagonism - increasing the agonist concentration will....
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reverse the block at its receptor or target
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What is the term for an antagonist that results from the antagonist binding to a different site on the receptor than the agonist?
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non competitive antagonist
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physiological/ functional antagonism are ....
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two drugs that act on entirely different receptors to elict opposing effects
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