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27 Cards in this Set
- Front
- Back
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What are the 3 ways drugs are classified into?
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Molecular structure
Mode of action Therapeutic use |
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How many names does a drug have?
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3
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What is the term used for the study of the effects of drugs on biological processes?
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Pharmacodynamics
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Anti-cancer & antibacterial drugs targets (nucleic acid/enzymes/transporter/ion channels/receptor)
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nucleic acid
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Statins inhibit (nucleic acid/enzymes/transporter/ion channels/receptor)
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enzymes
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Angiotensin converting enzyme (ACE) inhibits (nucleic acid/enzymes/transporter/ion channels/receptor)
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enzymes
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Selective serotonin reuptake inhibitor such as fluoxetine targets (nucleic acid/enzymes/transporter/ion channels/receptor)
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transporters
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Local anaesthetics blocks (nucleic acid/enzymes/transporter/ion channels/receptor)
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ion channels
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Acetylcholine, noradrenaline and adrenaline targets (nucleic acid/enzymes/transporter/ion channels/receptor)
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receptors
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What are the 4 families of receptor?
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1. Ligand-gated ion channels
2. G-protein coupled receptors 3. Enzyme-linked receptor 4. Intracellular |
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Ligands which are either hydrophilic or too large such as insulin DOES NOT use (ligand-gated ion channel/G-protein coupled receptors/Enzyme-linked receptor/intracellular)
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intracellular
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The shape of the drug must be ________ to the 3-D contours of the binding site on the target molecule
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complementary
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(ionic bond/hydrogen bond/van der waals forces) occurs between centers of opposite charge. The bond can exert long range attraction
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Ionic bond
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(ionic bond/hydrogen bond/van der waals forces) operates in short range helps to create and stabilise the drug-target complex once the drug is in close proximity to its binding site
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Hydrogen bond
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(ionic bond/hydrogen bond/van der waals forces) is the weakest bond but most common interactions between atoms and molecules. Very short range. Helps to stabilise the drug-target complex
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Van Der Waals
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What is not a reversible bond?
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Covalent bond
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___________ agents are drugs used in the chemotherapy of cancer and kill rapidly dividing cells by covalently binding to DNA, preventing DNA replication and RNA and protein synthesis
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Alkylating agents
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(Agonist/Antagonist) are drugs that bind to a receptor and produce a biological response similar to that produce by the endogenous ligand for the receptor
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Agonist
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(Agonist/Antagonist) are drugs that decrease the biological response to an agonist drug or endogenous ligand
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Antagonist
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(Carbachol/Phenylephrine/Heroin) is a similar chemical to acetylcholine
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Carbachol
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(Carbachol/Phenylephrine/Heroin) is a similar chemical to Noradrenaline
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Phenylephrine
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(Carbachol/Phenylephrine/Heroin) is a similar chemical to opioid peptides
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Heroin
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What is the antagonist for acetylcholine (atropine/propanolol)
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atropine
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What is the antagonist for noradrenaline (atropine/propanolol)
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propanolol
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a typical concentration response curve to an agonist is a ________ response
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graded
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Response to agonist drugs are ____________ dependent
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concentration
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If a competitive antagonist is added the typical log concentration-response curve will shift to the (left/right)
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right
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