Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
|
The action of heparin can be reversed by treatment with
|
administration of antagonist, protamine sulfate
|
|
|
MOA for Heparin
|
increase by 1000X fold antithrombin activity
|
|
|
Factors inhibited by antithrombin
|
II, Ix, X
|
|
|
Heparin contra-indication
|
HIT, active bleeding, hemophilia
|
|
|
Administration of Heparin
|
Only IV or Subcutaneous
|
|
|
Why is heparin not administered IM?
|
avoid risk of hematoma
|
|
|
LMW heparin (aka fractionated heparin)
better bioavailability more selective dose less frequently |
Enoxaprin
|
|
|
Drug of choice for anticoagulants in pregnancy
|
Heparin does not cross placental barrier
|
|
|
How to treat Heparin-induced thrombocytopenia?
|
Fondaparinux
|
|
|
Direct Thrombin Inhibitors
|
Desirudin and Bivalirudin and Leparudin
Argatroban and Melagatran |
|
|
Vitamin K dependent factors
|
VII, IX, X, II (thrombin), Protein C, Protein S
|
|
|
Metabolism of coumarin
|
Cyt P450- Liver
|
|
|
Thrombolytics
|
t-PA
Streptokinase Urokinase |
|
|
t-PA
|
Alteplase, Reteplase, Tenecteplase
|
|
|
Glycoprotein IIb/IIIa receptor
|
binds fibrinogen
|
|
|
antiplatelet-action to glycoproteinn IIb/IIIa receptor
|
abciximab
eptifibatide tirofiban |
|
|
platelet aggregationn promoting factors
|
ADP
TXA2 5-HT Serotonin |
|
|
PDE (phosphodiesterase 3) inhibitors
|
dipyridamole, cilostazol
|
|
|
Antiplasmin Agents
|
Aminocaproic Acid
Tranexamic Acid |
|
|
Desmopressin
|
vaspressinn V2 receptor agonist
|
|
|
Aprotinin
|
serine protease inhibitor
inhibits fibrinolysis by plasmin and by plasmin streptokinase complex |
|
|
MOA of ASA and NSAIDS
|
inhibit thomboxane synthesis by blocking the enzyme cyclooxygenase
|
|
|
MOA of clopidogrel and ticlopidine
|
irreversible inhibition of ADP mediated platelet aggregation
|
