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9 Cards in this Set
- Front
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Cholinergics *
[Cholinomimetics] (cholinergic agonists) Also list Indirect Cholinergics ** All have Parasympathetic response |
Direct*
Bethanecol (Urecholine) Carbachol (Miostat) Pilocarpine (Isoptocarpine, Salagen) Succinylcholine (Anectine) Indirect Cholinergics** Neostigmine (Prostigmin) Pyridostigmine (Mestinon) Donepezil (Aricept) Rivastigmine (Exelon) |
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Bethanecol (Urecholine)
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Class: Cholinergic
MOA:Direct Muscarinic (smooth muscle) Indication: Increases GI and urinary tract activity (smooth muscle contractions) AE: urinary urgency, abdominal cramps, N/V/D, hypotension, tachycardia from bradycardia) CI: GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy Route: PO |
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Carbachol (Miostat)
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Class: Cholinergic
MOA: Direct (non-specific) Nicotinic/muscarinic Indication: Treats glaucoma (high intraocular pressure) by reducing pressure and enhancing aqueous humor outflow AE: N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction) CI: GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy Route: Topically in eye |
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Pilocarpine
(1. Isoptocarpine) (2. Salagen) |
Class: Cholinergic
MOA: Direct muscarinic Indication: 1. (Isoptocarpine) Treats glaucoma 2. (Salagen) Increase salivation and salivary gland for dry mouth AE:N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction) CI:GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy Route: Isoptocarpine-glaucoma-topical in eye; Salagen-dry mouth-PO |
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Succinylcholine (Anectine)
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Class: Cholinergic
MOA: Direct Nicotinic (short-acting) Indication: Relaxant for skeletal muscles (pre-surgery) AE: N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction) CI: GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy |
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Neostigmine (Prostigmin)
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Class: Cholinergic
MOA: Indirect Nicotinic (skeletal muscle) Muscarinic Indication: Used for abdominal distension and urinary retension; Used to treat myasthenia gravis AE: N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction) CI: GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy |
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Pyridostigmine (Mestinon)
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Class: Cholinergic
MOA: Indirect Nicotinic, muscarinic Indication: To treat myasthenia gravis (longer-lasting than Neostigmine) AE: N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction) CI: GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy |
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1. Donepezil (Aricept)
2. Rivastigmine (Exalon) |
Class: Cholinergic
MOA: Both are Indirect Nicotinic, muscarinic, but Rivastigmine (Exalon) is longer lasting Indication: Delays cognitive deficits seen in Alzheimer’s Disease, increase cholinergic activity in CNS AE: N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction) CI: GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy Indication: To treat myasthenia gravis (longer-lasting than Neostigmine) AE: N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction) CI: GI or urinary tract obstruction, asthma (bronchoconstriction), Peptic Ulcer disease, CAD, Pregnancy |
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Cholinergics--List Adverse Effects
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For all: N/V/D, bronchoconstriction, increased bronchial secretions, bradycardia, sweating, saliva, miosis (pupil constriction)
For Bethanocol: add urinary urgency, abdominal cramps, hypotension, tachycardia or bradycardia |
