Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
Tricyclic Antidepressants
|
The acute effect of tricyclic drugs is to inhibit the reuptake mechanisms (transporters) responsible for the termination of the synaptic actions of both NE and 5-HT in the brain. This presumably results in potentiation of their neurotransmitter actions at postsynaptic receptors.
|
|
|
Selective Serotonin Reuptake Inhibitors
|
The acute effect of SSRIs is a highly selective action on the serotonin transporter (SERT). SSRIs allosterically inhibit the transporter, binding at a site other than that of serotonin
|
|
|
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
|
SNRIs bind to transporters for both serotonin and NE, presumably enhancing the actions of both neurotransmitters
The SNRIs differ from the TCAs in lacking significant blocking effects on peripheral receptors including histamine H1, muscarinic, or -adrenergic receptors. |
|
|
Serotonin 5-HT2 Receptor Antagonists
|
The major antidepressant actions of nefazodone and trazodone appear to result from block of the 5-HT 2A receptor, a G-protein–coupled receptor located in several CNS regions including the neocortex
|
|
|
MAOIs
|
Drugs inhibiting monoamine oxidases that metabolize norepinephrine and serotonin MAO type A) and dopamine (MAO type B)
|
|
|
Mirtazapine
|
Mirtazapine has a unique action to increase amine release from nerve endings by antagonism of presynaptic 2 adrenoceptors involved in feedback inhibition. The drug is also an antagonist at serotonin 5-HT 2 receptors
|
