Pharmacology Ch31 Opioids

Front 1

opioid receptors that may be involved in altering reactivity to pain are located in these regions of the brain?

Back 1

basal ganglia, hypothalamus, limbic structures, and cerebral cortex

Front 2

what are the types of opioid receptors?

Back 2

mu, delta, and kappa

Front 3

this opioid receptor plays a major role in the respiratory depressant actions of opioids?

Back 3

Mu receptor

Front 4

activation of this receptor is involved in the sedative actions of opioids?

Back 4

Kappa receptor

Front 5

all 3 major opioid receptors are coupled to their effector by these things?

Back 5

G proteins and activate phospholipase C or inhibit adenylyl cyclase

Front 6

at the postsynaptic level activation of the opioid receptors causes this to occur?

Back 6

opening of K+ channels to cause hyperpolarization (IPSP)

Front 7

at the presynaptic evel opioid receptor activation can close these ion channels?

Back 7

voltage gated Ca2+ channels to inhibit neurotransmitter release

Front 8

examples of strong opioids?

Back 8

morphine, methadone, meperidine, fentanyl, levorphanol, and heroin

Front 9

these opioid are partial agonists and have mild to moderate analgesic efficacy?

Back 9

Codeine, hydrocodone and oxycodone

Front 10

this agent is a very weak opioid agonist?

Back 10

Propoxyphene

Front 11

pupillary constriction is characteristic effect of all opioids except this one, which has a muscarinic blocking action?

Back 11

Meperidine

Front 12

this condition includes rhinorrhea, lacrimation chills, gooseflesh, muscle aches, diarrhea, yawning, anxiety and hostility?

Back 12

abstinenece syndrome

Front 13

which opioids are useful cough suppressants?

Back 13

Codeine and detromethorphan

Front 14

opioids used to treat diarrhea?

Back 14

loperamide and diphenoxylate

Front 15

this opioid may be useful in acute pulmonary edema because of its hemodynamic actions?

Back 15

Morphine

Front 16

what is the triad of opioid overdose signs?

Back 16

pupillary constriction, comatose state, and respiratory depression

Front 17

diagnosis of opioid overdose is confirmed by this action?

Back 17

IV injection of Naloxone (opioid antagonist)--->prompt signs of recovery

Front 18

concomitant use of certain opioid like meperidine with MAOIs can result in this condition?

Back 18

hyperpyrexic coma

Front 19

meperidine has also been implicated in serotonin syndrome when used with this antidepressant class?

Back 19

SSRIs

Front 20

the prolonged activity of Buprenorphine is clinically useful to suppress withdrawal signs in dependency states..how does this property affect Naloxone reversal efforts?

Back 20

Buprenorphine is resistant to naloxone reversal due to its prolonged activity

Front 21

this drug decreases the craving for Alcohol and is approved for adjunctive use in alcohol dependency programs?

Back 21

Naltrexone