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20 Cards in this Set
- Front
- Back
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what is the amine hypothesis of mood?
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postulates that brain amines, particularly NE and serotonin (5-HT) are neurotransmitters in pathways that function in the expression of mood- a funcitonal decrease in the activity of such amines -->depression and an increase --->mood elevation
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what is the acute effect of tricyclic drugs?
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to inhibit the reuptake mechanisms (transporters) responsible for the termination of synaptic actions of both NE and serotonin in the brain
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this drug has the unique action to increase amine release from nerve endings by antagonism of presynaptic alpha2 adrenoceptors?
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Mirtazapine (alpha2 receptors are involved in feedback inhibition)
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this is a common CNS side effect of tricyclic drugs and some heterocyclic agents?
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Sedation
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MAOIs, SSRIs, and bupropion are more likely to cause this CNS effect?
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CNS stimulation
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antagonism of these receptors occurs with all tricylcics?
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antagonism of muscarinic receptors (marked with amitriptyline and doxepin)
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what are the cardiovascular effects that occur most commonly with tricyclics?
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hypotension from alpha blockade and depression of cardiac conduction (may lead to arrhytmias)
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what happens to the convulsive threshold when on TCAs and MAOIs?
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lowers seizure threshold so seizures may occur (esp with overdoses)
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MAOIs are most useful in patients with these additional symptoms to depression?
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anxiety, phobic features, and hypochondriasis
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this class of drugs can also be used in the treatment of bipolar disorder, acute panic attacks, phobic disorders, enuresis, ADHD and chronic pain states
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TCAs
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high doses of this drug show efficacy in neuropathic pain?
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Venlafaxine
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these drugs are effective in Obsessive compulsive disorder?
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Clomipramine and SSRIs
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this class of drugs is also approved for use in pts with generalized anxiety disorders, panic attacks, social phobias, Bulemia, an dprementral dysphoric disorder and may be useful in alcohol dependence treatment?
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SSRIs
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this drug is used int eh management of patients attemptins to withdraw from nicotine dependence?
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Bupropion
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what are the 3 C's associated with TCA overdose?
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coma, convulsions, and cardiotoxicity
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a withdrawal syndrome has been described for this class fo drugs that includes nausea, dizziness, anxiety, tremor and palpitations?
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SSRIs
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this class of drugs are inhibitors of P450 which leads to increased activity of other drugs including TCAs and Warfarin?
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SSRIs
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this syndrome occurs with combo of fluoxetine and MAOI?
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serotonin syndrome
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define serotonin syndrome?
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life threatening syndrome includes severe muscle rigidity, myoclonus, hyperthermia, cardiovascualr instability, and marked CNS stimulatory effects including seizures
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MAOIs administered with this class of drugs can result in Serotonin syndrome?
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SSRIs
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