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10 Cards in this Set
- Front
- Back
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acyclovir
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(Zovirax)
-Antiviral for HSV -interferes w/ DNA synthesis -chicken pox, shingles, EBV -topical, oral, or parenteral -half life decreases over time -excreted in kidneys -very little metabolism (excreted as active compound) |
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pencyclovir
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(Denavir)
-acute tx -applied prior to appearance of lesions -topical -feels like tingling, heat sensation |
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valacyclovir
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(Valtrex)
-long term med -better absorption & bioavailability than acyclovir -suppressive tx and acute tx |
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docosanol
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(Abreva)
-OTC med -active oral herpes -not as effective as acyclovir |
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nystatin
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(Mycostatin)
-oral infections -macrolide AB -permeabilized cell membrane -not absorbed thru digestive or mucosa -applied directly to lesions, several mins at a time -oral suspension, lozenges, vaginal tablet -tx lasts 10-14 days |
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clotrimazole
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(Mycelex)
-oral suspension, lozenges, vaginal tablet -systemic, lipophilic -metabolized by CP450 -cross barrier --> drug interactions -GI distress -Preg cat C drug |
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fluconazole
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(Diflucan)
-systemic fungal infections -women w/ systemic yeast infection -drug interactions due to inhibition of CP450 (benzodiazepines, erythromycin, warfarin) decrease metabolism, increased levels in system |
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ketoconazole
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(Nizoral)
-Systemic tx -oral; requires acidic environment for absorption -inhibited by antacids -GI distress, hepatotoxcity -Preg cat C drug -given in hydrochloric acid soln -drug interactions due to inhibition of CP450 (benzodiazepines, erythromycin, warfarin) decrease metabolism, increased levels in system |
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amphotericin B
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-systemic infections
-parenteral - ad rxns: flu-like symptoms, GI distress, nephrotoxicity -many drug interactions -if other antifungal drugs have not worked b4 -immunocompromised: antiviral meds is a contraindication to fungal tx |
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griseofulvin
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-ringworm tx
-prevents fungal cell division -tx lasts until area grows out -ad rxns: photosensitivity, nightmares |
