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30 Cards in this Set
- Front
- Back
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First generation flouroquinolone. Use?
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Norflaxacin
UTI's |
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MOA of flouroquinolones
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Block DNA synthesis. Block topoisomerase II (DNA gyrase) in gram negatives and topoisomerase IV in gram positives
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Causes relaxation of supercoiled DNA required for transcription and duplication
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DNA gyrase
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MOA of sulfonamides
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Inhibit dihydropteroate synthase
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SE includes cartilage damage in pregnant women and children
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floroquinolones
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Anti-microbials that cause hemolysis in G6PD-deficient patients
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Sulfonamides
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Anti-biotic frequently used for chronic UTI prophylaxis
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sulfa-trimethoprim
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Anemia caused by trimethoprim
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Megaloblastic
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2nd generation flouroquinolones
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Ciproflaxacin and ofloxacin:
gram-, gonococcus, gram+ cocci, mycobacteria, agents of atypical pneumonia |
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3rd generation flouroquinolones
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levofloxacin, gatifloxacin:
S. pneumoniae, enterococci, and MRSA |
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4th generation flouroquinoles
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gemifloxacin, moxifloxacin:
broad spectrum w/ anaerbic activity |
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Very useful in diarrhea and UTI's caused by bacterial agents such as E coli, Shigella, C. Jejuni, and Salmonella
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Flouroquinolones
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Useful for the txmt of gonorrhea in individuals allergic to cephalosporins
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2nd generation quinolones:
Cipro and ofloxa |
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Effective txmt for individuals infected with both gonorrhea and C. trachomatis
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ofloxa...2nd gen
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Gonococcal resistance to flouroquinolones
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changes in DNA gyrase...gyrA gene
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Quinolone usedul for community acquired pneumonias including chlamydiae, mycoplasma, and legionella
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levofloxacin...3rd gen
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Flouroquinolones that prolong QT interval
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gemifloxacin(4th), levofloxacin(3rd), moxifloxicin(4th)
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MOA of trimethoprim
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Dihydrofolate reductase inhibitor
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Drug interactions with plasma protein bidning increases the levels of warfarin and methotrexate
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Sulfa
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Used in the txmt of toxoplasmosis
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Sulfadiazine and pyrimethamine
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Used for simple UTI's
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Triple sulfa, sulfasoxizole
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Ocular infections
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Topical sulfacetamide
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Burn infections
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Mafenide, silver sulfadiazine
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May displace bilirubin from PBP's with the risk of kernicterus in the neonate is used in the 3rd trimester
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Sulfa
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Used in the txmt of Toxoplasmosis in AIDS pt
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TMP-SMX
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DOC for prevention and txmt of pneumocystis pneumoniae
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TMP-SMX
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Used in ulcerative colitis and decreases inflammation of rheumatoid arthritis
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Sulfasalazine
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Adverse affect most likely to occur with sulfa
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Skin rash caused by hypersensitivity
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Supplementary folinic acid may prevent anemia in txmt with?
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Trimethprim:
Inhibitor of folic acid synthesis |
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AIDS pts given what may cause diarrhea, leukopenia, rashes, and fever.
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TMP-SMX
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