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29 Cards in this Set
- Front
- Back
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Where do corticosteroids bind to their receptor
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cytoplasm
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Main effects of glucocorticoids
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Stimulates gluconeogenesis:
Increases blood glucose, Protein degradation, and insulin secretion. Also stimulates lipolysis and lipogenesis. |
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Fat deposition of the shoulders and back
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Buffalo hump
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In children, what is the affects of glucocorticoids
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inhibits growth
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Glucocorticoids especially inhibit what immunologic functions?
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Lymphocytic dependent
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glucocorticoids are important in the txmt of what cancers
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hematologic
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Most potent glucocorticoid with high topical activity
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dexamethasone
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Glucocortiocids effects on the distribution % of leukocytes
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Increases neutrophils and decreases lympho's, eosino's, baso's, and mono's
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The biochemical effects of glucocorticoids on leukocytes is due to?
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Inhibition of phospholipase A2, decreased COX-2, inhibition of IL2 and IL3 and decrease in PAF.
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Major natural glucocorticoid
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cortisol(hydrocortisone)
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Cortisol secretion is most when?
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morning and least at night
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What is important to realize about the mineralcortiocid effects of cortisol
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It causes hypertension in those with an adrenal tumor or ACTH-secreting tumor.
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What synthetic glucocortoid has the closest potency to cortisol
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predisone...then triamcinolone
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What glucocorticoid effect is less in the synthetics
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salt-retaining potency
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Readily penetrate the airway mucosa but have short half-lives and are used in asthma
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Beclamethasone and budesonide
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Used for Addison's disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)
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Glucocorticoids
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Mechanism by which glucocortiocoid administration is useful for congenital adrenal hyperplasia
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Synthesis of abnormal forms of corticosteroids are stimulated by ACTH. In these conditions, glucocortiocid suppresses ACTH secretion and reduces the synthesis of abnormal steroids.
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Short acting glucocorticoids
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Cortisone and hydrocortisone
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Long acting glucocorticoids
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Betamethasone and dexamethasone
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Some side effects of corticosteroids
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Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis, stria, thinning of skin
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Period of time of therapy after which GC therapy will need to be tapered
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5-7 days
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Given to pregnent women in premature labor to hasten fetal lung maturity
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betamethasone
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Aldosterone antagonists
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Spironolactone and eplerenone
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Antifungal agent used for inhibition of ALL gonadal and adrenal steroids
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Ketaconazole
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Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
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aminoglutethimide
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Antiprogestin used as potent antagonist of GC receptor
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Mifepristone
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Common SE of spironolactone
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Gynecomastia and hyperkalemia
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Inhibits the normal synthesis of cortisol, but not that of cortisol precursors
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Metyrapone
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Useful in the txmt of chemo-induced vomiting
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glucocorticoids
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