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21 Cards in this Set
- Front
- Back
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Growth hormones effects are mediated through what?
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IGF-1
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HGH analog
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Somatropin and Somatrem
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Used in the txmt of Turner's Syndrome or Prader-Willi syndrome
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Somatropin
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Most controversial use of GH analogs
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idiopathic short stature
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IGF-1 analong
When is it prescribed? |
Mecasermin:
In children who are unresponsive to GH therapy due to deficient levels of IGF-1 and IGF binding protein 3 |
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Somatostatin analog. What is its function?
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Octeotride:
Inhibits the release of GH, glucagon, insulin, gastrin |
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D2 Dopamine receptor agonist. What is its function
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Bromocriptine:
Works as an antagonist to Inhibit secretion of prolactin |
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GH receptor antagonist approved for txmt of acromegaly
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Pegvisomant:
Long acting drug that enables cross-linking of receptors but cannot induce conformational changes. |
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Function of FSH in men? LH?
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FSH: spermatogenesis
LH: testicular androgen production |
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Ovulation induction may cause what pathological problems?
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Multiple pregnancies
Hyperstimulation syndrome |
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Mixture of FSH and LH purified from the urine of postmenopausal women
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Menotropin
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hCG is used to treat what condition?
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LH deficiency: hCG activates LH receptors
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LH analog
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Lutropin
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Purified FSH analog from urine of postmenopausal women
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Urofollitropin
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FSH analog
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Follitropin alpha and beta
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Ovulation induction protocol
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1. Administer GnRH agonist or antagonist to inhibit endogenous production.
2. Administer FSH to activate follicular development 3. Administer LH for oocyte maturation |
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GnRH agonsits MOA
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Down-regulate receptors in the pituitary gland
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GnRH agonist
What are they useful for |
Leuprolide, goserelin, histrelin, and nafarelin
Used in disorders that benefit from ovarian supression (endometriosis), in advanced prostate cancer, in children with precocious puberty, or in ovulation induction. |
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Symptoms of GnRH agonist txmt in women. Is long term txmt recommended?
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Postmenopausal symptoms: hot flashes, sweats, headaches
Long term txmt can cause osteoporosis and bone loss. |
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Adverse effects in men being treated with GnRH agonist
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Hot flushes, sweats, gyno, reduced libido, reduced bone density, decreased hematocrit
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GnRH antagonists. Onset of action?
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Ganirelix and Cetrorelix
Rapid onset |
