Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
fludarabine (purine antagonist)
|
fluorinate purine
MOA-phosphorylated in cell to active metabolite (2-fluroara-ATP)-->interferes w/ DNA synthesis and repair by inhibiting DNA polymerase uses-CLL side effect-myelosuppression |
|
|
cyclophosphamide
|
see previous treatments
|
|
|
rituximab
|
MOA-targets CD20 Ag on B cells; increases antitumor activity of cytoxic agents in CLL
sid effects-infusion reaction (hypotension, bronchospasm, angioedema, fever, chills) |
|
|
bendamustine
|
MOA: cross-links DNA-->DNA strand breakage-->decreases DNA synthethis
uses-CLL, non-hodgkin's side effects-myelosuppression |
|
|
alemtuzumab
|
humanized monoclonal Ab directed against CD52
MOA-depletes cells by direct Ab-dependent lysis uses-CLL in pts refractory to FCR regimen |
|
|
CHOP chemotherapy
|
cyclophosphamide
doxorubicin (hydroydaunorubicin) vincristine (oncovin) prednisone |
