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5 Cards in this Set
- Front
- Back
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anthracycline antibiotics MOA
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daunorubicin
doxorubicin (adriamycin) MOA: 1. intercalates DNA 2. inhibits topoisomerase II-->prevents DNA repair-->DNA damage **3. increase O2 free radicals-->scission of DNA strands |
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anthracycline clinical use
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daunorubicin-AMLs in combo w/ cytarabine
doxorubicin (broad spectrum) breast carcinomas, acute leukemia, hodgkin's lymphoma (ABVD), non-Hodgkin's lymphomas (CHOP) |
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anthracycline side effects
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urine discoloration (red)
**cardiomyopathy (cumulative, dose related)-manisfested by CHF, arrhythmias; forms frree radicals that bind to Fe in myocardium prevention of cardiac toxicity-administer dexrazoxane, which chelates Fe; decrease oxidation and O2 free radicals |
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pyrimidine antagonists MOA
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cytarabine
gemcitabine (flourinated analog of deoxycytidine) MOA-competetively inhibits DNA polymerase (chain elongation) and DNA synthethis |
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pyrimidine antagonists uses and side effects
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cytarabine-AML, lung and ovary cancers
gemcitabine-metastatic adenocarcinoma of pancreas side effects-myelosuppression, flu like symptoms |
