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21 Cards in this Set

  • Front
  • Back
Protamine sulfateis what kind of agent?
coagulation modifier agents
Therapeutic classification of protamine sulfate?
antidote
Pharmacologic classification of protamine sulfate?
antiheparin
Indication for the use of protamine sulfate ...
acute management of severe heparin?
overdosage
Indication for the use of protamine sulfate...used to neutralize?
heparin received during: dialysis
cardiopulmonary bypass
other procedures
Unlabeled uses of protamine sulfate include management of overdose of?
heparin-like compounds
MOA of protamine sulfate is?
a strong base that forms a complex with?
heparin (an acid)
Therapeutic effects of protamine sulfate?
Inactivation of heparin
Assess for what two blood-related problems while taking protamine sulfate?
bleeding
hemorrhage
Hemorrhage may recur how many hours after therapy because of which condition?
8-9

rebound effects of heparin
Rebound may occur as late as how many hours after therapy in patients heparinized for cardiopulmonary bypass
18 hrs
Assess for allergy to what food before giving protamine sulfate?
fish (salmon)
Assess for allergy to previous reaction to or use of protamine ________ or protamine _______
insulin
sulfate
Vasectomized and infertile men also have higher risk of _______ reaction.
hypersensitivity
Observe for signs and symptoms of hypersensitivity reaction which are?
hives
edema
coughing
wheezing
What should nurse keep close by in an event of anaphylaxis?
epinephrine (antihistamine)
resuscitative equipment
Assess for hypovolemia before initiation of therapy. Failure to correct may result in?
cardiovascular collapse from peripheral vasodilating effects of protamine sulfate
What type of lab tests should be monitored 5-15 minutes after therapy and again as necessary?
monitor clotting factors
ACT, activated clotting time
aPTT, activated partial
thromboplastin time
TT, thrombin time
Instruct patient to report ______ bleeding immediately.
recurrent
Advise patient to avoid activities (until risk of hemorrhage has passed) that may result in?
bleeding
ex: shaving
brushing teeth
receiving injections
or rectal temps
ambulating
Effectiveness of therapy can be demonstrated by?
control of bleeding
normalization of clotting
factors in heparinized
patients