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21 Cards in this Set
- Front
- Back
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Protamine sulfateis what kind of agent?
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coagulation modifier agents
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Therapeutic classification of protamine sulfate?
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antidote
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Pharmacologic classification of protamine sulfate?
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antiheparin
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Indication for the use of protamine sulfate ...
acute management of severe heparin? |
overdosage
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Indication for the use of protamine sulfate...used to neutralize?
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heparin received during: dialysis
cardiopulmonary bypass other procedures |
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Unlabeled uses of protamine sulfate include management of overdose of?
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heparin-like compounds
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MOA of protamine sulfate is?
a strong base that forms a complex with? |
heparin (an acid)
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Therapeutic effects of protamine sulfate?
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Inactivation of heparin
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Assess for what two blood-related problems while taking protamine sulfate?
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bleeding
hemorrhage |
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Hemorrhage may recur how many hours after therapy because of which condition?
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8-9
rebound effects of heparin |
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Rebound may occur as late as how many hours after therapy in patients heparinized for cardiopulmonary bypass
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18 hrs
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Assess for allergy to what food before giving protamine sulfate?
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fish (salmon)
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Assess for allergy to previous reaction to or use of protamine ________ or protamine _______
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insulin
sulfate |
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Vasectomized and infertile men also have higher risk of _______ reaction.
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hypersensitivity
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Observe for signs and symptoms of hypersensitivity reaction which are?
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hives
edema coughing wheezing |
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What should nurse keep close by in an event of anaphylaxis?
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epinephrine (antihistamine)
resuscitative equipment |
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Assess for hypovolemia before initiation of therapy. Failure to correct may result in?
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cardiovascular collapse from peripheral vasodilating effects of protamine sulfate
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What type of lab tests should be monitored 5-15 minutes after therapy and again as necessary?
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monitor clotting factors
ACT, activated clotting time aPTT, activated partial thromboplastin time TT, thrombin time |
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Instruct patient to report ______ bleeding immediately.
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recurrent
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Advise patient to avoid activities (until risk of hemorrhage has passed) that may result in?
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bleeding
ex: shaving brushing teeth receiving injections or rectal temps ambulating |
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Effectiveness of therapy can be demonstrated by?
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control of bleeding
normalization of clotting factors in heparinized patients |
