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10 Cards in this Set
- Front
- Back
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Clearance is typically a measure of ________ __________
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renal excretion
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The ________ are the primary site for elimination of gaseous and volatile compounds
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lungs
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Enterohepatic recirculation - how the fuck they work?
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free drug is conjugated in the liver -> secreted in bile as glucuronide conjugate -> bacterial glucuronidase converts back to free drug -> free drug is absorbed in the intestine and goes back through portal circulation -> profit
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what is back diffusion?
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passive reabsorption of lipid soluble, unionized drugs in the proximal tubule
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Why are hydrophilic/lipophobic substances more easily eliminated by the kidney?
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they do not cross the membrane in the proximal tubule as well
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To increase excretion of weak acidic drugs, _________ urinary pH
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increase
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To increase excretion of weak basic drugs, _________ urinary pH
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decrease
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Drugs eliminated entirely by glomerular filtration have a max CL of __________
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120 ml/min
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Max clearance from blood by hepatic metabolism is __________
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1500ml/min
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_______ order kinetics are independent of drug concentration
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zero
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