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10 Cards in this Set
- Front
- Back
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Variation in endogenous receptor ligand concentrations impacts what kind of drugs?
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antagonists and partial agonists
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Biological variability reflected in variations in effective drug doses is primarily caused by what?
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differences in pharmacokinetics ADME (not receptor sensitivity)
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_________-dose response curves show the distribution of effective doses in a group
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quantal
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_________-dose response curves show the intensity of drug response in an individual
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graded
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_________ = continual scale; ____________ = all-or-none
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graded; quantal
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Define ED50
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dose producing effect in 50% of the population
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+/- 1 SD captures ______% of the population
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~68%
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+/- 2 SD captures _________% of the population
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~95%
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+/- 3 SD captures ____% of the population
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~99.6%
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less variability = ________ std. deviation
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smaller
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