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23 Cards in this Set
- Front
- Back
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What plasma protein can bind to drugs such as Warfarin, decreasing the amount of available drug?
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Albumin
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The concentration of plasma proteins such as Albumin in the blood is insignificant in calculating an effective dosage. True or false?
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False
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Name 4 factors that affect the protein binding of drugs.
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Age, Trauma/illness, Ethnicity, Gender
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The concentration of unbound Diazepam in women is greater than in men. True or False?
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True
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Counter displacement is the act of adding drug A to drug B to decrease the concentration of drug A. True or False?
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False
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Counter displacement is the act of adding drug A to drug B to increase the concentration of drug A. True or False?
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True
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If 90% of drug A is bound to a plasma protein, adding a new drug can decrease the concentration of drug A bound to plasma protein, hence increasing the unbound concentration of Drug A. True or False?
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True
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The placenta is less permeable to drugs that the brain. True or False?
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True
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Weak bases distribute better than weak acids. True or False?
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True
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Weak acids distribute better than weak bases. True or False?
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False
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Vd stands for what?
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Volume of Distribution (Litres)
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How is Vd calculated?
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Amount of drug in body in grams/plamsa concentration in g/L
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The Vd of Insulin is 4 and Warfarin is 8. True or False?
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True
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If the Vd is high, it shows that the drug is more diluted than it should be (in the blood plasma), meaning more of it is distributed in tissue (i.e. not in plasma). True or False?
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True
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Drugs with high lipid solubility (non-polar), low rates of ionization or low plasma binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma binding in the body's environment. True or False?
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True
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Bioaccumulation is the accumulation of compounds within a food chain, of which those at the top are least severely affected. True or False?
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False
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Bioaccumulation is the accumulation of compounds within a food chain, of which those at the top are most severely affected. True or False?
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True
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Zero order kinetics is characterised by what sort of line on a graph of Time against Cp?
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Linear/Straight line
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First order kinetics is characterised by what sort of line on a graph of Time against Cp?
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Curve
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Half-life (T1/2) is a factor in first order kinetics only. True or False?
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True
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Define Half-life (T1/2).
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The time needed to eliminate 1/2 of drug
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Does multiple dosing ultimately increase or decrease the drug concentration over time?
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Increase
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It is impossible to attain steady state if elimination follows zero order kinetics - eg. alcohol. True or False?
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True
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