Pharmacology Biom1008 - Cardiovascular Pharmacology

Front 1

Cardiac rate and rhythm is governed by the balanced opening and closing of _________________________________, which generate electrical activity.

Back 1

Voltage operated membrane proteins

Front 2

The refractory period is the period of time where you cannot stimulate another action potential. True or False?

Back 2

True

Front 3

Anti-dysrhymic drugs try to decrease the refractory period. True or False?

Back 3

False.

Front 4

Anti-dysrhythmic drugs try to increase the refractory period. True or False?

Back 4

True

Front 5

The autonomic nervous system controls heart rate _____________ (acting at the sinoatrial node) and force of contraction INOTROPY in the ventricle.

Back 5

Chronotropy

Front 6

Sympathetic stimulation decreases heart rate and force of contraction. True or False?

Back 6

False

Front 7

Vagal stimulation decreases heart rate but has very little effect on contraction (lack of receptors in ventricle). True or False?

Back 7

True

Front 8

Sympathetic stimulation increases heart rate and force of contraction. True or False?

Back 8

True

Front 9

What does ERP stand for?

Back 9

Effective Refractory Period

Front 10

What type of drugs are class I Anti-dysrhythmic Drugs?

Back 10

Na+ Channel Blocker

Front 11

Class 1a Anti-dysrhythmic Drugs blocks electrical conduction and increases ERP. True or False?

Back 11

True

Front 12

Class 1a Anti-dysrhythmic Drugs blocks electrical conduction and decreases ERP. True or False?

Back 12

False

Front 13

Give 2 examples of Class 1a Anti-dysrhythmic Drugs.

Back 13

Quinidine, Disopyramide

Front 14

Class 1b Anti-dysrhythmic Drugs blocks electrical conduction and decreases ERP. True or False?

Back 14

True

Front 15

Class 1b Anti-dysrhythmic Drugs blocks electrical conduction and increases ERP. True or False?

Back 15

False

Front 16

Give 2 examples of Class 1b Anti-dysrhythmic Drugs.

Back 16

Lidocaine, Mexiletine

Front 17

Class 1c Anti-dysrhythmic Drugs blocks electrical conduction and either has no effect on ERP or decreases. True or False?

Back 17

False

Front 18

Class 1c Anti-dysrhythmic Drugs blocks electrical conduction and either has no effect on ERP or increases. True or False?

Back 18

True

Front 19

Give 2 examples of Class 1c Anti-dysrhythmic Drugs.

Back 19

Felcainide, Encainide

Front 20

What type of drugs are class II Anti-dysrhythmic Drugs?

Back 20

β Adrenoceptor Antagonists

Front 21

Class II Anti-dysrhythmic Drugs decrease sinus node automaticity. True or False?

Back 21

True

Front 22

Class II Anti-dysrhythmic Drugs increase sinus node automaticity. True or False?

Back 22

False

Front 23

Give 2 examples of Class II Anti-dysrhythmic Drugs.

Back 23

Propanolol, Sotalol

Front 24

Class III Anti-dysrhythmic Drugs are types of drugs that prolong the action potential duration. True or False?

Back 24

True

Front 25

Class III Anti-dysrhythmic Drugs have no effect on conduction but delays repolarisation. True or False?

Back 25

True

Front 26

Class III Anti-dysrhythmic Drugs delays on conduction but has no effect on repolarisation. True or False?

Back 26

False

Front 27

Give 3 examples of Class III Anti-dysrhythmic Drugs.

Back 27

Bretylium, Amiodarone, Sotalol

Front 28

What type of drugs are class IV Anti-dysrhythmic Drugs?

Back 28

Ca^2+ antagonists

Front 29

Class IV Anti-dysrhythmic Drugs quickens conduction velocity in the atrial-ventricular node (AVN). True or False?

Back 29

False

Front 30

Class IV Anti-dysrhythmic Drugs slows conduction velocity in the atrial-ventricular node (AVN). True or False?

Back 30

True

Front 31

Give 2 examples of Class IV Anti-dysrhythmic Drugs.

Back 31

Verapamil, Diltiazem

Front 32

Sympathetic nervous system stimulation will increase the force and speed of muscle contraction in the ventricle, and increase the rate of action potential firing in the sinoatrial node. True or False?

Back 32

True

Front 33

Digoxin is a cardiac glycoside which inhibits Na+/K+ ATPase pumps, causing Na levels inside cells to increase. True or False?

Back 33

True

Front 34

Digoxin is a cardiac glycoside which inhibits Na+/K+ ATPase pumps, causing Na levels inside cells to decrease. True or False?

Back 34

False

Front 35

Inotropic drugs - Cardiac Glycosides - cause an Increased force of contraction due to increased calcium release from intracellular stores – result of effect of increased sodium. True or False?

Back 35

True

Front 36

Inotropic drugs - Cardiac Glycosides - such as Digoxin can be used to treat heart failure. True or False?

Back 36

True

Front 37

Glucagon is a drug type which Increases Myocardial Contraction. True or False?

Back 37

True

Front 38

Give an example of a Glucagon drug.

Back 38

Adenylate cyclase

Front 39

Phosphodiesterase Inhibitors can be used to increase Myocardial Contraction. True or False?

Back 39

True

Front 40

Give an example of a Phosphodiesterase Inhibitor.

Back 40

Milrinone

Front 41

The appropriate response to angina would be to reduce O2 consumption, reduce preload, afterload. True or False?

Back 41

True

Front 42

The appropriate response to a Coronary Spasm would be to relieve the spasm. True or False?

Back 42

True

Front 43

Give an example of an antiplatelet drug.

Back 43

Asprin

Front 44

Give an example of an oral anticoagulant drug.

Back 44

Warfarin

Front 45

Give an example of an Injectable anticoagulant drug.

Back 45

Heparin

Front 46

Statins decrease the synthesis of Cholesterol. True or False?

Back 46

True

Front 47

Statins, Resins and Fibrates increase cholesterol uptake of hepatocytes. True or False?

Back 47

True

Front 48

Resins bind cholesterol to bile acids to be excreted into the duodenum. True or False?

Back 48

True

Front 49

Resins do not bind cholesterol to bile acids to be excreted into the duodenum. True or False?

Back 49

False

Front 50

Ezitimibe increases the absorption of cholesterol into the blood stream from the stomach. True or False?

Back 50

False

Front 51

Ezitimibe reduces the absorption of cholesterol into the blood stream from the intestines. True or False?

Back 51

True