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57 Cards in this Set

  • Front
  • Back
Based on the Characteristics of an Ideal Psychotherapeutic Drug by Hollisberg and Csernasnsky (1990), in which of the following factors would a newer atypical antipsychotic agent (e.g., ziprasidone) compare more favorably to an older typical antipsychotic agent (e.g., thioridazine)?
a. Be effective rapidly.
b. Benefit most of all patients for who it is indicated.
c. Not impair motor function
d. Not be lethal in overdose
e. All the above are correct
f. None of the above are correct
c. Not impair motor function
The dopamine hypothesis of schizophrenia states that:
a. Mesolimbic dopamine activity is higher than normal.
b. Mesocortical dopamine activity is higher than normal.
c. The alterations in mesolimbic dopamine activity are responsible for the negative symptoms of schizophrenia.
d. The alterations in mesocortical dopamine activity are responsible for the positive symptoms of schizophrenia.
e. All the above are correct
f. None of the above are correct
a. Mesolimbic dopamine activity is higher than normal.
Which of the following is/are true about antipsychotic drug therapy?
a. The side effects caused by antipsychotics are primarily due to blockade of the D2 dopamine receptor subtype.
b. Most antipsychotic agents are more effective in decreasing the positive symptoms as compared to the negative symptoms of schizophrenia
c. The side effects of antipsychotic agents can not always be reversed by discontinuation of D2 antagonist therapy.
d. Atypical antipsychotic agents can cause extrapyramidal side effects.
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Some of the major clinical benefits of atypical antipsychotics would include:
a. Very low incidence of side effects mediated by antagonism of histaminergic, cholinergic and adrenergic receptor subtypes.
b. Better clinical efficacy toward positive symptoms of schizophrenia.
c. Reduced likelihood of developing Parkinson-like motor deficits.
d. Weight loss and decreased blood lipid levels.
e. All the above are correct
f. None of the above are correct
c. Reduced likelihood of developing Parkinson-like motor deficits.
Antihistaminergic side effects might be expected to occur during treatment with:

a. Thioridazine
b. Pimozide
c. Olanzapine
d. Aripiprazole
e. All the above are correct
f. None of the above are correct
a. Thioridazine
Which of the following drugs has significant agonist effects at 5HT-2 receptors?
a. Loxapine
b. Haloperidol
c. Olanzapine
d. Ziprasidone
e. All the above are correct
f. None of the above are correct
f. None of the above are correct
Although most of the atypical antipsychotic agents have a lower incidence of causing extrapyramidal symptoms, which of the following drugs would be expected to have the least risk of this side effect?
a. Olanzepine
b. Aripiprazole
c. Quetiapine
d. Risperidone
e. All the above are correct
f. None of the above are correct
b. Aripiprazole
Gynecomastia in males might be expected to occur after long term treatment with:
a. Pimozide
b. Fluphenazine
c. Haloperidol
d. Loxapine
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Anticholinegic side effects might be expected to occur during treatment with:
a. Thioridazine
b. Clozapine
c. Mesoridazine
d. Olanzepine
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Side effects caused by blockade of alpha-1 adrenergic receptors might be expected to occur during treatment with:
a. Pimozide
b. Thioridazine
c. Perphenazine
d. Haloperidol
e. All the above are correct
f. None of the above are correct
b. Thioridazine
Many antipsychotic drugs block alpha-1 adrenergic receptors. The side effect(s) produced by blocking these receptors would include:
a. Sedation
b. Constipation
c. Dystonia
d. Postural hypotension
e.All the above are correct
f. None of the above are correct
d. Postural hypotension
Based on the Characteristics of an Ideal Psychotherapeutic Drug by Hollisberg and Csernasnsky (1990), which of the following factors would a newer atypical antipsychotic agent (e.g., ziprasidone) compare more favorably to an older typical antipsychotic agent (e.g., thioridazine)?
a) Be effective rapidly.
b) Benefit most or all patients for who it is indicated.
c) Have minimum toxicity in the therapeutic range
d) Not be lethal in overdose
e) All the above are correct
f) None of the above are correct
f) None of the above are correct
The dopamine hypothesis of schizophrenia states that:
a) Mesolimbic dopamine activity is lower than normal.
b) Mesocortical dopamine activity is higher than normal.
c) The alterations in mesolimbic dopamine activity are responsible for the negative symptoms of schizophrenia.
d) The alterations in mesocortical dopamine activity are responsible for the positive symptoms of schizophrenia.
e) All the above are correct
f) None of the above are correct
f) None of the above are correct
Which of the following is/are true about antipsychotic drug therapy?
a) The therapeutic efficacy of antipsychotics is primarily due to blockade of the D2 dopamine receptor subtype.
b) Most antipsychotic agents are more effective in decreasing the positive symptoms as compared to the negative symptoms of schizophrenia
c) The side effects of antipsychotic agents can always be reversed by discontinuation of D2 antagonist therapy.
d) Atypical antipsychotic agents do not cause extrapyramidal side effects.
e) All the above are correct
f) None of the above are correct
b) Most antipsychotic agents are more effective in decreasing the positive symptoms as compared to the negative symptoms of schizophrenia
Some of the major clinical benefits of most of the newer atypical antipsychotics include:
a) Much safer therapeutic index in the elderly compared to haloperidol.
b) Reduced likelihood of developing gynecomastia compared to haloperidol
c) Reduced likelihood of weight gain compared to haloperidol.
d) Better clinical efficacy toward positive symptoms of schizophrenia compared to haloperidol.
e) All the above are correct
f) None of the above are correct
b) Reduced likelihood of developing gynecomastia compared to haloperidol
Antihistaminergic side effects might be expected to occur during treatment with:
a) Pimozide
b) Chlorpromazine
c) Olanzapine
d) Aripiprazole
e) All the above are correct
f) None of the above are correct
b) Chlorpromazine
Which of the following drugs has clinically significant antagonist effects at 5HT-2 receptors?
a) Loxapine
b) Haloperidol
c) Olanzapine
d) Ziprasidone
e) All the above are correct
f) None of the above are correct
e) All the above are correct
Although most of the atypical antipsychotic agents have a lower incidence of causing extrapyramidal symptoms, which of the following drugs would be expected to have the least risk of this side effect?
a) Olanzepine
b) Risperidone
c) Quetiapine
d) Aripiprazole
e) All the above are correct
f) None of the above are correct
d) Aripiprazole
Anticholinergic side effects might be expected to occur during treatment with:
a) Mesoridazine
b) Clozapine
c) Thioridazine
d) Olanzepine
e) All the above are correct
f) None of the above are correct
e) All the above are correct
Many antipsychotic drugs block alpha-1 adrenergic receptors. The side effect(s) produced by blocking these receptors would include:
a) Postural hypotension
b) Constipation
c) Dystonia
d) Sedation
e) All the above are correct
f) None of the above are correct
a) Postural hypotension
Which of these agents has higher affinity for D2 dopamine receptors compared to its affinity for muscarinic acetylcholine receptors?
a) Trifluoperizine
b) Pimozide
c) Fluphenazine
d) Haloperidol
e) All the above are correct
f) None of the above are correct
e) All the above are correct
Based on the “Characteristics of an Ideal Psychotherapeutic Drug” by Hollisberg and Csernansky (1990), for which of the following factors would a newer atypical antipsychotic agent (e.g., ziprasidone) compare more favorably to older typical antipsychotic agents (e.g., thioridazine)?
a. Be effective rapidly.
b. Benefit most or all patients for who it is indicated.
c. Not impair cognitive, perceptual or motor functions
d. Not be lethal in overdose
e. All the above are correct
f. None of the above are correct
c. Not impair cognitive, perceptual or motor functions
The dopamine hypothesis of schizophrenia proposes that:
a. Mesolimbic dopamine activity is higher than normal.
b. Mesocortical dopamine activity is lower than normal.
c. The alterations in mesolimbic dopamine activity are responsible for the positive symptoms of schizophrenia.
d. The alterations in mesocortical dopamine activity are responsible for the negative symptoms of schizophrenia.
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Some common uses of antipsychotic therapy currently include:
a. Amphetamine-induced hallucinations
b. Motion sickness
c. Autism with aggressive symptoms
d. Bipolar depression
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Which of these agents has lower affinity for D2 dopamine receptors compared to its affinity for muscarinic acetylcholine receptors?
a. Thioridazine
b. Pimozide
c. Fluphenazine
d. Haloperidol
e. All the above are correct
f. None of the above are correct
a. Thioridazine
Which of the following is/are true about antipsychotic drug therapy?
a. The therapeutic efficacy of antipsychotic agents is due to their ability to correct the imbalance in dopamine neurotransmission that occurs in the brain of schizophrenic patients.
b. Most antipsychotic agents are more effective in decreasing the positive symptoms as compared to the cognitive symptoms of schizophrenia
c. The maximal efficacy of antipsychotic agents occurs within a couple of days after the initiation of treatment.
d. Most schizophrenic patients, once they are diagnosed, take these agents continuously throughout their lifetime.
e. All the above are correct
f. None of the above are correct
b. Most antipsychotic agents are more effective in decreasing the positive symptoms as compared to the cognitive symptoms of schizophrenia
Many antipsychotic drugs block alpha-1 adrenergic receptors. The side effect(s)produced by blocking these receptors would include:
a. Weight gain
b. Dizziness
c. Dystonia
d. Sedation
e. All the above are correct
f. None of the above are correct
b. Dizziness
Antihistaminergic side effects might be expected to occur during treatment with:
a. Aripiprazole
b. Pimozide
c. Clozapine
d. Haloperidol
e. All the above are correct
f. None of the above are correct
c. Clozapine
Although most of the atypical antipsychotic agents have a lower incidence of causing extrapyramidal symptoms, akathisia is more likely to occur after initiating treatment with:
a. Clozapine
b. Risperidone
c. Quetiapine
d. Aripiprazole
e. All the above are correct
f. None of the above are correct
b. Risperidone
Tardive dyskinesia:
a. May be due to down-regulation of striatal GABA activity.
b. Is decreased by concurrent therapy with a cholinergic agonist.
c. Occurs more frequently in older females over the age of 55.
d. May last for years after discontinuation of nonselective D2 antagonist treatment
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Some of the major clinical benefits of most of the newer atypical antipsychotics includes:
a. Significantly lower incidence of side effects mediated by antagonism of histaminergic, cholinergic and adrenergic receptor subtypes compared to thioridazine.
b. Somewhat better clinical efficacy toward negative and cognitive symptoms of schizophrenia compared to thioridazine.
c. Reduced likelihood of developing Parkinson-like motor deficits compared to thioridazine.
d. Reduced likelihood of developing gynecomastia compared to thioridazine.
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Based on the Characteristics of an Ideal Psychotherapeutic Drug by Hollisberg and Csernasnsky (1990), which of the following factors would a newer atypical antipsychotic agent (e.g., ziprasidone) compare more favorably to an older typical antipsychotic agents (e.g., thioridazine)?
a. Be effective rapidly.
b. Benefit most or all patients for who it is indicated.
c. Not impair cognitive, perceptual or motor functions
d. Not be lethal in overdose
e. All the above are correct
f. None of the above are correct
c. Not impair cognitive, perceptual or motor functions
The dopamine hypothesis of schizophrenia states that:
a. Mesolimbic dopamine activity is higher than normal.
b. Mesocortical dopamine activity is lower than normal.
c. The alterations in mesolimbic dopamine activity are responsible for the positive symptoms of schizophrenia.
d. The alterations in mesocortical dopamine activity are responsible for the negative symptoms of schizophrenia.
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Some common uses of antipsychotic therapy currently include:
a. Amphetamine-induced hallucinations
b. Motion sickness
c. Autism with aggressive symptoms
d. Bipolar depression
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Which of these agents has lower affinity for D2 dopamine receptors compared to its affinity for muscarinic acetylcholine receptors?

a. Thioridazine
b. Pimozide
c. Fluphenazine
d. Haloperidol
e. All the above are correct
f. None of the above are correct
a. Thioridazine
Which of the following is/are true about antipsychotic drug therapy?
a. The therapeutic efficacy of antipsychotic agents is due to their ability to correct the imbalance in dopamine neurotransmission that occurs in the brain of schizophrenic patients.
b. Most antipsychotic agents are more effective in decreasing the positive symptoms as compared to the cognitive symptoms of schizophrenia
c. The maximal efficacy of antipsychotic agents occurs within a couple of days after the initiation of treatment.
d. Most schizophrenic patients, once they are diagnosed, take these agents continuously throughout their lifetime.
e. All the above are correct
f. None of the above are correct
b. Most antipsychotic agents are more effective in decreasing the positive symptoms as compared to the cognitive symptoms of schizophrenia
Many antipsychotic drugs block alpha-1 adrenergic receptors. The side effect(s) produced by blocking these receptors would include:
a. Weight gain
b. Dizziness
c. Dystonia
d. Sedation
e. All the above are correct
f. None of the above are correct
b. Dizziness
Antihistaminergic side effects might be expected to occur during treatment with:

a. Aripiprazole
b. Pimozide
c. Clozapine
d. Haloperidol
e. All the above are correct
f. None of the above are correct
c. Clozapine
Although most of the atypical antipsychotic agents have a lower incidence of causing extrapyramidal symptoms, akathisia may occur after initiating treatment with:

a. Clozapine
b. Risperidone
c. Quetiapine
d. Aripiprazole
e. All the above are correct
f. None of the above are correct
b. Risperidone
Tardive dyskinesia:
a. may be due to down-regulation of striatal GABA activity.
b. is decreased by concurrent therapy with a cholinergic agonist.
c. occurs more frequently in older females over the age of 55.
d. May last for years after discontinuation of nonselective D2 antagonist treatment
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Some of the major clinical benefits of most of the newer atypical antipsychotics includes:
a. Significantly lower incidence of side effects mediated by antagonism of histaminergic, cholinergic and adrenergic receptor subtypes compared to haloperidol.
b. Somewhat better clinical efficacy toward negative and cognitive symptoms of schizophrenia compared to haloperidol.
c. Reduced likelihood of developing Parkinson-like motor deficits compared to haloperidol.
d. Reduced likelihood of developing gynecomastia compared to haloperidol.
e. All the above are correct
f. None of the above are correct
e. All the above are correct
Which of the following is/are true about antipsychotic drug therapy?
a. The therapeutic efficacy of antipsychotic agents is due to their ability to correct the imbalance in dopamine neurotransmission that occurs in the brains of schizophrenic patients.
b. Most antipsychotic agents are more effective in decreasing the negative symptoms as compared to the cognitive symptoms of schizophrenia
c. Selectivity in blocking 5-HT2 and D4 receptors without blocking D2 receptors is proposed to increase therapeutic efficacy and decrease side effects.
d. Atypical antipsychotic agents do not cause extrapyramidal side effects.
e. All the above are correct
f. None of the above are correct
c. Selectivity in blocking 5-HT2 and D4 receptors without blocking D2 receptors is proposed to increase therapeutic efficacy and decrease side effects.
Which of the following is/are true about antipsychotic drug therapy?

a. The therapeutic efficacy of antipsychotics is primarily due to blockade of the D4 dopamine receptor subtype.
b. Most antipsychotic agents are more effective in decreasing the negative symptoms as compared to the cognitive symptoms of schizophrenia
c. The extrapyramidal side effects of antipsychotic therapy can not be chemically separated from the therapeutic actions of these drugs.
d. The extrapyramidal side effects of antipsychotic agents can not always be reversed by discontinuation of D2 antagonist therapy.
e. All the above are correct
f. Only A, B and C are correct
g. Only A and C are correct
d. The extrapyramidal side effects of antipsychotic agents can not always be reversed by discontinuation of D2 antagonist therapy.
Some of the major clinical benefits of most of the newer atypical antipsychotics includes:

a. Significantly lower incidence of side effects mediated by antagonism of histaminergic, cholinergic and adrenergic receptor subtypes compared to haloperidol.
b. Markedly better clinical efficacy toward negative and cognitive symptoms of schizophrenia compared to haloperidol.
c. Reduced likelihood of developing Parkinson-like motor deficits compared to haloperidol.
d. Reduced likelihood of weight gain compared to haloperidol.
e. All the above are correct
f. Only A, B and C are correct
g. Only A and C are correct
c. Reduced likelihood of developing Parkinson-like motor deficits compared to haloperidol.
Gynecomastia in males might be expected to occur after long term treatment with:

a. Pimozide
b. Respiridone
c. Haloperidol
d. Aripiprazole
e. All the above are correct
f. Only A, B and C are correct
g. Only A and C are correct
f. Only A, B and C are correct
Many antidepressants and antipsychotics block H-1 histamine receptors. The side effect(s) produced by blocking H-1 receptors would include:

a. Weight gain
b. Priapism
c. Sedation
d. Dystonia
e. All the above are correct
f. Only A, B and C are correct
g. Only A and C are correct
g. Only A and C are correct
Tardive dyskinesia:

a. Is due to an up-regulation of D2 receptors in caudate-putamen.
b. Is decreased by concurrent therapy with L-DOPA.
c. Is characterized by severe restlessness and agitation.
d. May last for years after discontinuation of nonselective D2 antagonist treatment
e. All the above are correct
f. Only A, B and C are correct
g. Only C and D are correct
g. Only C and D are correct
Anticholinergic side effects might be expected to occur during treatment with:

a. Mesoridazine
b. Clozapine
c. Amitriptyline
d. Paroxetine
e. All the above are correct
f. Only A, B and C are correct
g. Only A and C are correct
e. All the above are correct
Side effects caused by blockade of alpha-1 adrenergic receptors might be expected to occur during treatment with:
a. Mesoridazine
b. Clozapine
c. Amitriptyline
d. Paroxetine
e. All the above are correct
f. Only A, B and C are correct
g. Only A and C are correct
f. Only A, B and C are correct
Which of the following drugs has clinically significant antagonist effects at 5HT-2 receptors?
A. Risperidone
B. Olanzapine
C. Trazodone
D. Trifluoperazine
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
F. Only A, B and C are correct
Which of the following is/are true about antipsychotic drug therapy?
A. Atypical antipsychotics must occupy at least 80% of striatal D2-dopamine receptors in order to produce symptomatic relieve from positive and negative symptoms of schizophrenia.
B. Most antipsychotic agents are more effective in decreasing the negative symptoms as compared to the positive symptoms of schizophrenia
C. The maximal efficacy of antipsychotic agents takes weeks to develop.
D. The side effects of antipsychotic agents can always be reversed by discontinuation of D2 antagonist therapy.
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
C. The maximal efficacy of antipsychotic agents takes weeks to develop.
Some of the major clinical benefits of atypical antipsychotics would include:
A. Very low incidence of side effects mediated by antagonism of histaminergic, cholinergic and adrenergic receptor subtypes.
B. Better clinical efficacy toward positive symptoms of schizophrenia.
C. Reduced likelihood of developing Parkinson-like motor deficits.
D. Weight loss and decreased blood lipid levels.
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
C. Reduced likelihood of developing Parkinson-like motor deficits.
Gynecomastia in males might be expected to occur after long term treatment with:
A. Pimozide
B. Amoxapine
C. Haloperidol
D. Aripiprazole
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
F. Only A, B and C are correct
Many antidepressants and antipsychotics block H-1 histamine receptors. The side effect(s) produced by blocking H-1 receptors would include:
A. Weight loss
B. Catalepsy
C. Dystonia
D. Sedation
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
D. Sedation
Tardive dyskinesia:
A. is probably due to an up-regulation of specific D2 receptor populations
B. is decreased by concurrent therapy with anticholinergics or L-DOPA
C. Is characterized by catatonia and motor rigidity
D. Develops within weeks after the initiation of D2 antagonist treatment
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
A. is probably due to an up-regulation of specific D2 receptor populations
Anticholinegic side effects might be expected to occur during treatment with:
A. Thioridazine
B. Pimozide
C. Paroxetine
D. Haloperidol
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
G. Only A and C are correct
Side effects caused by blockade of alpha-1 adrenergic receptors might be expected to occur during treatment with:
A. Doxepin
B. Fluoxetine
C. Pimozide
D. Haloperidol
E. All the above are correct
F. Only A, B and C are correct
G. Only A and C are correct
A. Doxepin