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36 Cards in this Set
- Front
- Back
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Glucocorticoids work by? used in?
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Suppressing WBC, used in ALL to decrease leukemic cells
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Antiestrogens used in?
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breast, uterine, cervix, ovarian cancer
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Antiandrogens used in?
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Testicular and prostate cancer
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Tamoxifen is a ?
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Estrogen partial agonist that competes with estrogen for receptor binding
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Tamoxifen used for?
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to reduce risk of developing breast tumors in strong family history
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Tamoxifen tox?
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Hot flashes
DVT PE linked to endometrial cancer and blood clots |
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Tamoxifen positve effects on?
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Positive estrogenic effects on bone and cholesterol
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Tamoxifen stops working after?
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about 5 years
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Toremifene works by?
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increasing TNF
Decreases cell proliferation decreases cell growth |
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Toremifene used in?
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Estrogen dependent breast cancers
being looked at in prostate cancer prophylaxis |
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Raloxifene is a?
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Selective estrogen receptor modulator
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Raloxifene works as a?
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antagonist in breast and uterine tissue
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Raloxifene mainly used in?
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osteoporosis
Approved to reduce risk of breast cancer risk |
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Fulvestrant is a?
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Selective estrogen receptor down regulator
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Fulvestrant works as a?
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PURE anti-estrogen
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Fulvestrant used in?
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hormone sensitive metastatic breast cancer
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Anastrozole/Letrozole are?
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Nonsteroidal competitive aromatase inhibitors
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Anastrazole/Letrozole usef in?
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All women with postmenoausal estrogen snsitive breast cancer
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What is replacing Tamoxifen?
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Anastrazole/Letrozole because it maintains activity after 5 years
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Exemestane is a ?
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Irreversible steroidal aromatase suicide inhibitor
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Exemestane usef in? to?
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In postmenopausal women after a few years of Tamoxifen
Decrease estrogen by 90% |
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Exemestane tox?
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Visua disturbances and bone fractures
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Flutamide/Nilutamide/Bicalutamide are?
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Synthetic nonsteroidal anti-androgens
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Flutamide/Nilutamide/Bicalutamide used in?
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Prostate cancer
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Flutamide/Nilutamide/Bicalutamide work by?
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blocking androgen receptor
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Flutamide/Nilutamide/Bicalutamide given with?
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Leuprolide or goserelin
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Flutamide/Nilutamide/Bicalutamide may cause
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Gynecomastia
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Leuprolide/Goserelin are?
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Analogs of GnRH to occupy LHRH receptor
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may see what S/E in Leuprolide/Goserelin?
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impotence
hot flashed gynecomastia |
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Interferon alpha MOAs?
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- increases cytotox of natural killer cells
- increases phagocytic ability of macrophages - increases ability ot macrophage to present antigen |
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Interferon alpha used in?
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Hairy cell, Kaposi, Heptatitis
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Interferon alpha S/E?
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Flu-like
Hair loss CNS effects |
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Aldesleukin will do what?
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stimulate proliferation anf activation of lymphokine-activated killer cells
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Aldesleukin used in?
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metastatic cancers
usually in later stages |
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Aldesleukin side effects?
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Flu-like syndrome
Capillary leak syndrome Hypotension (can be severe) Edema Arrhythmias CNS |
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Aldesleukin cautiously used in?
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Cardiac, renal, pulmonary, hepatic or seizures
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