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12 Cards in this Set

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What do fibric acid derivatives do?
primarily affect triglyceride levels...
may decrease LDL and increase HDL
What is one way clofibrate works?
increases release of antidiuretic hormone from?
posterior pituitary
What is another way clofibrate works?
blocks arginine-induced inculin and glucagon secretion by?
pancreas
What is one way clofibrate works?

decreases fasting blood glucose concentrations and serum insulin concentrations in patients with?
doabetes mellitus
Clofibrate may increase which labs?
AST (SGOT)
ALT (SGPT)
amylase
CPK
LDH
Clofibrate decreases?
fibrinogen levels
Clofibrate enhances oral anticoagulants (decreases fibrinogen levels)...so?
adjust dosage
Which drug can displace clofibrate from inactive storage sites?
furosemide
MOA of fibric acid derivatives?
may activate lipoprotein lipase, which is an enzyme responsible for?

triglyceride molecule leaving behind lipoproteins
breakdown of cholesterol...Lipoprotein cleaves off?
Fibric acid derivatives can also suppress release of?

triglycerides in liver...increase secretion of cholesterol into?
fatty acid from adipose tissue...it can inhibit synthesis of?

bile
Fibric acid derivatives (Clofibrate) does what?
decreases triglyceride levels
decreases serum LDL and LDL
concentrations
changes in blood coagulation
by decreasing platelet
adhesiveness (enhances
oral anticoagulants)
increases plasma fibrinolysis
which is the process that
breaks down clots
increases HDL by as much as
25%
Some side effects include?
GI problems
increased risk of
gallstones
acute appendicitis
GU problems
Other
rash
drowsiness
headache