Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
What do fibric acid derivatives do?
|
primarily affect triglyceride levels...
may decrease LDL and increase HDL |
|
|
What is one way clofibrate works?
increases release of antidiuretic hormone from? |
posterior pituitary
|
|
|
What is another way clofibrate works?
blocks arginine-induced inculin and glucagon secretion by? |
pancreas
|
|
|
What is one way clofibrate works?
decreases fasting blood glucose concentrations and serum insulin concentrations in patients with? |
doabetes mellitus
|
|
|
Clofibrate may increase which labs?
|
AST (SGOT)
ALT (SGPT) amylase CPK LDH |
|
|
Clofibrate decreases?
|
fibrinogen levels
|
|
|
Clofibrate enhances oral anticoagulants (decreases fibrinogen levels)...so?
|
adjust dosage
|
|
|
Which drug can displace clofibrate from inactive storage sites?
|
furosemide
|
|
|
MOA of fibric acid derivatives?
may activate lipoprotein lipase, which is an enzyme responsible for? triglyceride molecule leaving behind lipoproteins |
breakdown of cholesterol...Lipoprotein cleaves off?
|
|
|
Fibric acid derivatives can also suppress release of?
triglycerides in liver...increase secretion of cholesterol into? |
fatty acid from adipose tissue...it can inhibit synthesis of?
bile |
|
|
Fibric acid derivatives (Clofibrate) does what?
|
decreases triglyceride levels
decreases serum LDL and LDL concentrations changes in blood coagulation by decreasing platelet adhesiveness (enhances oral anticoagulants) increases plasma fibrinolysis which is the process that breaks down clots increases HDL by as much as 25% |
|
|
Some side effects include?
|
GI problems
increased risk of gallstones acute appendicitis GU problems Other rash drowsiness headache |
