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20 Cards in this Set
- Front
- Back
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What is the primary use of Heparin? Other use?
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Surgical Anticoagulation
Another use is as an acute MI |
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What is heparins MOA?
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Complexes with ATIII and inhibits Factor IIa and Factor Xa. It also inhibits XII and XI by an ionic mechanism
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What is the proper dose of protamine to reverse one 5000 IU of heparin
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50mg
one unit is inhibited by 1 microgram |
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What are the major contraindications of heparin
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HIT, coagulation abnormality, AT-III deficiency (would do nothing)
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What is the use of low MW heparins such as enoxaparin?
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Prevention of DVT, ACT, post surgical at home prophylaxis
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What is the indication of fondaparinux?
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Management of DVT (oral drug)
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What are the indications of recombinant AT-III?
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DIC, Sepsis, Thrombophilla, hypercoagulable states.
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How would you monitor the functionality of LMW heparin?
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anti-Xa testing NOT aPTT
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What is the function of argatroban?
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Direct thrombin inhibitor
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What are the indications of argatroban?
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Anticoagulation in HIT patients
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How would you monitor argatroban?
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aPTT
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What are the indications of Bivalrudin
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Anticoagulation in HIT, PCI
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What is the MOA of Hirudin
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Direct thrombin inhibition
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That are the indications of Warfarin?
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A-fib, DVT, generally long term anticoagulation
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What is a contraindication of Warfarin?
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Pregnancy!
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What are the challenges of Warfarin management?
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High albumin affinity, affected by many other drugs, requires regular monitoring. Variation of effect with dief.
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What is the primary use of Vit K?
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Given to newborns to initiate production of coagulation cascade proteins. Also, used to reverse Warfarin
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What are the side effects of Warfarin
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Coumadin induced necrosis, bleeding
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What are the side effects of Vit K?
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Hemolysis, sometimes anaphylaxis
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What are the side effects of protamine?
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Bradycardia, hypotension, anaphylaxis (especially if allergic to fish)
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