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25 Cards in this Set
- Front
- Back
Amphotericin B MOA?
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Given IV, Binds ergosterol in fungus cell membrane and makes pores
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Amphotericin B spectrum?
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Broadest spectrum of all anti-fungals
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Amphotericin B SE?
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Infusion related:Rever, Rigors (premedicate)
Slow Toxicities: Nephrotoxicity Electrolyte abnormalities |
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Amphotericin B dose regulation with renal failure?
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Only if creatinine is above 3
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Amphotericin Liposomal?
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decreases toxic effects, ABELCET and AMBISOME
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Nystatin
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Topical, Binds ergosterol in fungus cell membrane and makes pores,
Giin for Candida |
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5 Flucytosine MOA?
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inhibits neucleic acid synthesis, always used synergistically with Amphotericin B/Azoles
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5 Flucytosine Spectrum?
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Cryptococcus neoformans
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5 Flucytosine SE?
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GI: NVD, toxic megacolon
Hepatomegaly/ increased transaminases Bone marrow suppression |
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Azole MOA?
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Inhibits CYP450-dependent lanosterol C14 demethylation (enzyme needed for ergosterol synthesis), faulty cell membrane synthesis
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Clotrimazole?
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Azole, Imidazole, used topically for candida
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Itracanazole?
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Azole, Triazole, DOC for Dimorphic Fungi(histoplasma, blastomyces, sporothrix. Given orally and IV(propylene glycol can cause renal impaiment, Interactions: needs acid to absorb
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Fluconazole?
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Azole, cheap, well tolerated, broad spectrum, not aspergillus and not dimorphic Fungi, DOC for Cryptococcal meningitis
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Viroconazole?
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DOC for Aspergillus, increase use for prophylaxis selects for zygomyces infection
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Pozaconazole?
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Orally with fatty meal, broad spectrum, well tolerated, very expensive
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Griseofulvin?
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Systemic, fungistatic, for dermatophytosis of skin, hair, nails, need long treatment(6-12 months)
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Terbinafine
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Fungicidal, dematophytosis/ onychomycosis
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Tropically used for Candida?
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Clotrimazole
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DOC for Dimorphic Fungi?
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Itraconazole
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DOC for Cryptococcal Meningitis?
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Fluconazole
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DOC for Aspirgillus?
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Viroconazole
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Like Amphotericin B but well tolerated and expensive?
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Pozaconazole
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Echinocandins?
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caspofungin, Micafungin, Anidulofungin
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Spectrum of Echinocandins?
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Fungicidal for yeast
Fungistatic for Aspergillus |
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MOA of Echinocandins?
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Inhibit cell wall synthesis
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