Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/25

Click to flip

25 Cards in this Set

  • Front
  • Back
Amphotericin B MOA?
Given IV, Binds ergosterol in fungus cell membrane and makes pores
Amphotericin B spectrum?
Broadest spectrum of all anti-fungals
Amphotericin B SE?
Infusion related:Rever, Rigors (premedicate)
Slow Toxicities: Nephrotoxicity
Electrolyte abnormalities
Amphotericin B dose regulation with renal failure?
Only if creatinine is above 3
Amphotericin Liposomal?
decreases toxic effects, ABELCET and AMBISOME
Nystatin
Topical, Binds ergosterol in fungus cell membrane and makes pores,
Giin for Candida
5 Flucytosine MOA?
inhibits neucleic acid synthesis, always used synergistically with Amphotericin B/Azoles
5 Flucytosine Spectrum?
Cryptococcus neoformans
5 Flucytosine SE?
GI: NVD, toxic megacolon
Hepatomegaly/ increased transaminases
Bone marrow suppression
Azole MOA?
Inhibits CYP450-dependent lanosterol C14 demethylation (enzyme needed for ergosterol synthesis), faulty cell membrane synthesis
Clotrimazole?
Azole, Imidazole, used topically for candida
Itracanazole?
Azole, Triazole, DOC for Dimorphic Fungi(histoplasma, blastomyces, sporothrix. Given orally and IV(propylene glycol can cause renal impaiment, Interactions: needs acid to absorb
Fluconazole?
Azole, cheap, well tolerated, broad spectrum, not aspergillus and not dimorphic Fungi, DOC for Cryptococcal meningitis
Viroconazole?
DOC for Aspergillus, increase use for prophylaxis selects for zygomyces infection
Pozaconazole?
Orally with fatty meal, broad spectrum, well tolerated, very expensive
Griseofulvin?
Systemic, fungistatic, for dermatophytosis of skin, hair, nails, need long treatment(6-12 months)
Terbinafine
Fungicidal, dematophytosis/ onychomycosis
Tropically used for Candida?
Clotrimazole
DOC for Dimorphic Fungi?
Itraconazole
DOC for Cryptococcal Meningitis?
Fluconazole
DOC for Aspirgillus?
Viroconazole
Like Amphotericin B but well tolerated and expensive?
Pozaconazole
Echinocandins?
caspofungin, Micafungin, Anidulofungin
Spectrum of Echinocandins?
Fungicidal for yeast
Fungistatic for Aspergillus
MOA of Echinocandins?
Inhibit cell wall synthesis