Pharmacology Anti-Depress/anxiety/convulse/parkinson, Bi Polar

Front 1

MAO Inhibitors promote accumulation of which neurotransmitters?

Back 1

dopamine
epinephrine
norepinephrine

Front 2

MAO Inhibitor

a) isocarboxazid (marplan)
b) amitriptyline (amitiril)
c) doxapin (sinequan)

Back 2

isocarboxazid (marplan)

all that end in ____ine are tricyclic antidepressants

Front 3

antidepressant not commonly used due to deadly acute hypertension due to interaction w common diets

a) amopaxine (asendin)
b) venlafaxine (effexor)
c) isocarboxazid (marplan)

Back 3

isocarboxazid (marplan)

also causes constipation
confusion, insomnia, poor memory, suicide

Front 4

antidepressant not likely to cause constipation

a) isocarboxazid (marplan)
b) imipramine (impril)
c) sertraline (zoloft)
d) fluoxetine (prozac)

Back 4

sertraline (zoloft)

also venlafaxine (effexor)

Front 5

fluoxetine (prozac) inhibits CNS reuptake of serotonin and norepinephrine

Back 5

F

inhibits reuptake of serotonin but NOT norepi

tricyclic antidepressants s/a amitriptyline (amitril) inhibit reuptake of serotonin AND norepi

Front 6

may cause withdrawal symptoms of NV, HA, malaise after longterm therapy

a) Prozac
b) amoxapine (asendin)
c) isocarboxazid (marplan)

Back 6

prozac - avoid alcohol

tricyclic antidepressants amoxapine (asendin)- also cause constipation, and impotence

Front 7

largely non-specific and used for a variety of depressive, compulsive and eating disorders though has had a high rate of suicide

a) protriptyline (triptil)
b) fluoxetine (prozac)
c) venlafaxine (effexor)

Back 7

fluoxetine (prozac)

also causes
constipation, sinusitis, sweat
convulsions, psychosis, insomnia, hyperventilation, UTI, impotence, eye pain

Front 8

takes up to 4 weeks to develop a blood line during which the most adverse effects occur

a) zoloft
b) effexor
c) prozac

Back 8

prozac

Front 9

avoid w alcohol

a) meprobamate
b) zoloft
c) prozac

Back 9

prozac

Front 10

used for antidepressive, and compulsive conditions but not for eating disorders

a) zoloft
b) effexor
c) prozac

Back 10

zoloft
(effexor)

Front 11

may cause death if given within 14 days of a MAO inhibitor

a) phenelzine (nardil)
b) sertraline (zoloft)
c) bezodiazapines

Back 11

zoloft

Front 12

T/F

prozac decreases clearance of diazepam and tolbutamide

Back 12

F

Zoloft

Front 13

Group of anti-anxiety drugs that can relax smooth muscle and act as anticonvulsants

Back 13

benzodiazapines

all end in ___am except chlordiazepoxide

Front 14

tx for acute alcohol withdrawal

a) chlordiazapoxide (librium)
b) diazepam (valium)
c) meprobramate (miltown)
d) buspirone (buspar)

Back 14

chlordiazapoxide (librium)

type of benzodiazapine

valium-> CV collapse/ respiratory depression
buspar- no potential for abuse
miltown- depressed WBC, Coma, Death

Front 15

Warning: when used with antacid such as tagamet, sedation effect are increased significantly

Back 15

benzodiazapines such as xanex/valium

Front 16

_______can be especially addictive within _____days at low doses. do not take longterm.

Back 16

xanax- addictive at 2mg/day for 3 days

Front 17

T/F

Benzodiazepines are safe for longterm use

Back 17

F

addictive w longterm use

Front 18

anti-anxiety drug that is seldom used due to its ability to cause death/coma w mild overdose

a) meprobamate (miltown)
b) Busparin (buspar)
c) prazepam (centrax)

Back 18

meprobamate (miltown)

Front 19

used only for anxiety and is not a controlled drug bc it has shown no potential for abuse

a) hydroxycine (atarax)
b) buspirone (buspar)
c) oxazepam (serax)

Back 19

buspirone (buspar)

may cause: drowsy, dizzy, nervous, insomnia, HA, dry mouth, NV, diarrhea, fatigue

Front 20

anti-anxiety and anti-nauseant

a) hydroxycine (atarax)
b) buspirone (buspar)
c) carbamazepine (mazepine)

Back 20

hydroxycine (atarax)- suicide drug

Front 21

anticonvulsant that works by stabilizing neuronal cell membranes in the motor cortex by controlling the amount of Na+ efflux/influx

a) carbamazepine (mazepine)
b) phenytoin (delantin)
c) ethosuximide (zarontin)
d) gabapentin (neurontin)

Back 21

carbamazepine (mazepine)
phenytoin (delantin)

Front 22

major adverse effect of carbamazepine (mazepine)

a) NV
b) Bone Marrow Depression
c) gingival hyperplasia
d) constipation

Back 22

Anticonvulsant -> Bone Marrow Deprssn

also: CHF w larger doses, urinary frequency, impotence, sweat, hepatitis

Front 23

major adverse effect of Hydantoins

a) NV
b) CHF
c) gingival hyperplasia
d) constipation

Back 23

gingival hyperplasia

hydantoins end in ___toin except for phenacemide (phenurone)

Front 24

T/F

Gabapentin do not have an effect on GABA receptors

Back 24

True

structurally represent GABA but no effect on receptors

Front 25

anticonvulsant that is commonly used to treat chronic pain but may cause constipation and lazy eye

a) ethotoin (peganone)
b) gabapentin (neurontin)
c) methsuximide (zarontin)

Back 25

gabapentin (neurontin)

also causes leukopenia

Front 26

tx petit mal seizures

a) Phenobarbital (luminal)
b) Clonazepam (klonopin)
c) ethosuximide (zarontin)

Back 26

ethosuximide (zarontin) - succinimides

may cause: bone marrow supression, Gingival Hyperplasia, vag bleeding, rash Hirsutism, HA, fatigue,

Front 27

______ and ______ may cause gingival hyperplasia

Back 27

succinimides and hydantoins

Front 28

work to increase seizure threshold

a) Hydantoins
b) gabapentin (neurontin)
c) succinimides
d) phenobarbitol (luminol)

Back 28

succinidmides- depress nerve transmission to motor cortex- petit mal seizures

phenobarbitol- depress mono/poly synaptic transmission in motor cortex - child seizures

Front 29

may cause paradoxical excitement in elderly

a) carbamazepine (mazepine)
b) phenacemide (phenurone)
c) phenobarbitol (luminal)
d) phensuximide (milontin)

Back 29

phenobarbitol (luminal)

causes drowsiness, NV, rash, hives

Front 30

condition for which drugs alter the Na/K transport across cell membrane in nerve and muscle cells and balance biogenic amines

Back 30

bi-polar

tx- lithium carbonate
(lithium= Na/K family but lighter)

Front 31

may harm the fetus

a) levodopa
b) lithium carbonate
c) benzodiazepines

Back 31

lithium carbonate

may cause: circulatory collapse, abnormal urine, incontinence, hyponatremia, itch, brain damage when used with haloperidal,

Front 32

crosses the blood brain barrier

Back 32

levodopa (dopa)

Front 33

adverse effects of anti-parkinson meds include

a) suicidal tendencies
b) hypertension
c) priapism
d) hepatotoxicity

Back 33

ALL

also: ataxia, memory loss, anxiety, nitemares, dementia, othrostatic hypotension, incontinence, inappropriate sexual behavior

Front 34

T/F

levodopa cabidopa cross the blood brain barrier

Back 34

F

inhibits peripheral decarboxylation of levodopa w/o affecting levodopa metab in CNS

Front 35

drug of choice for terminating seizure

Back 35

valium

(klonapin- used for maintenence)

Front 36

commonly used for childhood seizures

Back 36

phenobarbital (luminal)
paradoxic excitation w elderly