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14 Cards in this Set
- Front
- Back
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What are the injectable steroid anesthetic drugs?
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Althesin or Saffan
= Alphaxalone + Alphadolone |
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What is Alphaxalone?
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a Pregnanediol derivative
Hypnotic - but still exhibits CNS stimulatory fx (thus combine with Alphadolone) |
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What is Alphadolone?
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Pregnanediol Acetate derivative
Another hypnotic steroid. |
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What is Althesin?
What is it used for? |
combo of
3 Alphaxalone : 1 Alphadolone anesthesia of cats and lab animals only in UK and Australia |
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Is Althesin water solube?
What is the pH? How is it administered? |
steroids, haha --- NO!
pH 7.0 IV, NON-irritating (fx of administering via other routes are variable) |
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Which is more potent:
Alphaxolone of Alphadolone? |
Alphaxalone
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What is the mechanism of action of Althesin?
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same as barbs, phenols, imidazoles...
allosteric on GABAa keeps GABA on there longer |
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What are the principle effects of Althesin?
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smooth and rapid induction, rapid recovery
NO ANALGESIA EEG - like barbs *Markedly reduced cerebral blood flow and O2 consumption Anticonvulsive does NOT accumulate - drip it! |
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Can I use this drug in horses?
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NO!
assoc w/ excitement, spasm, violent leg movement (okay you can use it, but give xylazine with it!) |
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ADVERSE EFFECTS:
Cats |
10-50% have anaphylactoid rxn
-mostly mild (swelling of paws/ears gone in 1-2 hours) -occasional face swelling, larygneal edema, bronchospasm, pulmonary edema |
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ADVERSE EFFECTS:
Dogs |
Particularly Sensitive - CONTRAINDICATED in DOGS
Profound Hypotension |
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ADVERSE EFFECTS:
Respiratory Side Fx |
Rare (maybe with really high doses)
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ADVERSE EFFECTS:
Cardiovascular Side Fx |
Rare (maybe with really high doses)
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Describe the PK of Althesin...
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does NOT distribute in fat
undergoes Rapid Hepatic Metabolism by alpha-hydroxylation 60-80% eliminated via bile |
