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Acetaminophen (Tylenol)
Pregnancy Class B Oral, Rectal supp., |
Reduces pain, fever by Inhibiting prostaglandin synthesis in the cns and peripherally. does not produce gastric irritation or ulceration, and has a minimal anti-inflammatory effect. Major side effect- liver damage
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Acetaminophen overdose- gastric lavage (stomach pumping)within 4 hours of ingestion/activated charcoal to inhibit absorption. Acetylcysteine (mucomyst) given orally as antidote best within 8-10 but might still effective up to 36 hours.
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acetaminophen adverse effects
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drowsiness/stimulation, nausea, vomiting, abdominal pain, hepatotoxicity, hepatic seizure (overdoese), GI bleeding, renal failure, rash. Interacts with St. Johns wort (reduces effect); barbituates/hydantoins-decreased effects/increased hepatotoxicity.
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Acetaminophen toxicity symptoms- cyanosis, anemia, neutropenia, jaundice, pancytopenia, CNS stimulation, delirium followed by vascular collapse, seizures, coma, death.
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