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17 Cards in this Set
- Front
- Back
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High conc. of acetyl choline block cholinergic transmisssion mainly in what kind or receptor?
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nicotinic receptors
-affects skeletal muscle -transmission at ganglia (symp and parasymp.) "wet and wild" |
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Effects of cholinesterase inhibition are
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-Muscarinic stimulation of organs "wet and wild"
-Nicotinic stimulation followed by antagonism -CNS stimulatoin of cholinoceptors |
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Effects of cholinesterase inhibition on cardiovascular system
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brady cardia
cardiogenic shock |
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Effects of cholinesterase inhibition on respiratory system
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Brohchoconstriction
Increased secretion Paralysis of diaphragm |
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Effects of cholinesterase inhibition on GI tract
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Increased tone
Increased motility Increased secretions |
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Effects of cholinesterase inhibition on Skin
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Increased sweating
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Effects of cholinesterase inhibition on the Eye
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Miosis
Near accommodation |
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Effects of cholinesterase inhibiton on the CNS
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Tremor
Anxiety Confusion Confusion Convulsions Coma |
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Tx of poisoning by cholinesterase inhibitors
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Atropine to block muscarinic effect
Pralidoxime (2-PAM) for reactivation of enzyme |
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Effects of muscarinic receptor Antagonism on CNS
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Low dose: drowsiness, amnesia, dreamless sleep
High Dose: excitement, confusion, hallucinations, coma |
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Effects of muscarinic receptor antagonism on the Eye
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Pupillary dilation, paralysis or accommodation, increased intraocular pressure
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Effects of muscarinic receptor antagonism on the CV system
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Tachycardia, antagonized vasodilation and hypotension produced by choline esters
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Effects of muscarinic receptor antagonism on the respiratory system
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Brohchodilation, inhibits secretion and reduces mucociliary clearance
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Effects of muscarinic receptor antagonism on GI and urinary tract
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Inhibiton of GI tone and peristalsis, complete blockade of salivary secretion, in hibition of gastric acid secretion, urinary retention
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Effects of muscarinic receptor antagonism on skin
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inhibits sweating
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Antimuscarinics: Adverse Effects
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Blind as a Bat
Dry as a bone Red as a beet Mad as a hatter |
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Uses of muscarinic cholinocepter antagonists
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Prevent motion sickness
Produce sedation, amnesia and tranquilization Produce mydriasis and cycloplegia Inhibit salivationa nd respiratory tract secretions Tx of cholinomimetic poisoning |
