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417 Cards in this Set
- Front
- Back
Name 1and 2in penicillin |
1thiazolidine ring 2beta lactam ring |
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Terminal d-alanine is removed by ___ and help in rigidity if bacterial cell wall |
Transpeptidases |
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___ drugs inhibit lipid transport of N---NAG of bacterial cell wall |
Bacitracin |
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Glycopeptide antibiotic moa is |
Inhibitor of d alanine |
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Beta lactams which inhibits cross linking are |
Pcmc Penicillin Cephalosporin Monobactam Carbapenames |
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Ex of bactericidal drugs |
Polymixin Daptomycin Acts on cell membrane |
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Apart from mrsa vancomycin acts on |
Enterococcus faecium |
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Doc for gonorrhea |
Ceftrixone if resistent spectinomycin |
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Rxoc for psuedomonas infection |
Ceftazidime + gentamicin |
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Doc for serratia and enterobacter is |
Carbapenams |
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Imipenam always combined with ___ so that renal dihydropeptidase is inhibited |
Cilastin |
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Longest acting carbipenam not acting against acinatobacter |
Ertapenam |
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Monabactams act against |
Gr -ve organisms |
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Allergic to penicilln doc is |
Monobactams |
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Cefatetan given for colorectal surgeries s/e is |
Disulfiram like reactions Hypoprothrombinemia |
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Mc cause among penicillin which cause pseudomembranous enterocolitis is Among cepholosporins? |
Ampicillin 3rd generation cephalosporins |
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Polymixin B is used for |
Local bladder irrigation |
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Doc for resistent pseudomonas |
Polymixins |
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Drug acting on cell membrane which is c/i in pneumonia is |
Daptomycin |
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In ribosomes of bacteria compeitive inhibitor of A site is___ drugs |
Tetracycline |
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___ drugs binds to A site jn ribosomes and cause misreading of proteins |
Aminoglycosides |
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trna on p site moves to E site and gets ejected and 5aas on A site moves to free P site so now new trna with aas joins A site this process in bacteria is called __ Drugs inhibit this are called__ |
Translocation Chloramphenicol |
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Tetracycline- doxycycline is doc for |
My mycoplasma hominis Pink pleurodesis pericardiodesis R rickettesia B brucella borrelia C chlamydia cholera |
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Tetracyclines+ aminoglycosides used in |
Plaque and tuleremia |
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Tetracycline of choice in siadh |
Demeclocycline |
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Yellowish discoloration of teeth is seen with antibiotic |
Tetracyclines |
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Tetracyclin which causes vestibular toxicity is |
Minocycline |
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Aminoglycoside used for gut sterilization in hepatic encephalopathy pt |
Neomycin Doc rifaximin |
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Most toxic aminoglycoside is |
Neomycin |
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Azithromycin is doc for |
Atypical pneumonia Chancroid Campylobacter |
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Macrolide with s/e as pain at inj site is |
Streptogramines |
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Doc for anerobic bacteria |
Lincosamide- clindamycin |
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A macrolide which is cidal drug is |
Streptogramines |
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Doc for shigella and travellers diarrohoea etec |
Ciprofloxacin |
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Respiratory quinolones eg? S/e? |
Gemifloxacin Gatifloxacin Levofloxacin Moxifloxacin S/e QT prolongation |
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Qt prolongation is maximum in __FQ |
Sparfloxacin |
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Longest acting FQ |
Moxifloxacin |
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Sulfadiazine and pyrimethamine is used in toxoplasmosis but in pregnancy doc is |
Spiramycin |
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Antifolate antibiotic used in rhematoid arthritis and ulcerative colitis |
5amino salicylic acid |
|
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Longest acting sulphanomide is |
Sulfadoxime |
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In antica drugs M phase inhibitors are |
Vt 3E Vinka alkaloids Taxans Epothilones Eribulin Estromustin |
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During antica therapy nausea and vomitings due to increase in neurokinin 1 is prevented by |
Neurokinin1inhibitor aprepitant |
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S/e of ifosfomide is |
Hemorrhagic cystitis Neurotoxicity |
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Vesication is s/e of __ antica drug |
Mechlor ethamine |
|
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Nitrosureas used in pancreatic ca and carcinoid syndrome |
Streptozocin |
|
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Current doc for brain tumours is |
Temozalamide Alkylating agent with methylation |
|
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Common s/e of all platinum compounds is |
Peripheral neuropathy |
|
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Anthracyclin group for multiple sclerosis is Nitrogen mustard is |
Mitoxantrone Melphalan |
|
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Dono rubicin and doxirubicin are cardio toxic chelated by |
Dexra rubicin |
|
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Common s/e of antifolate drugs in S phase inhibitors is |
Bone marrow suppression |
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In S phase inhibitor of antifolate drugs pemetrexed has marked bone marrow supression along with leucovorin vit___ is given as rx |
Vitb12 |
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Capcitabine acts>5hrs and it shows hand foot syndroms so vit___ is given |
Vit b6 |
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Pyrimidine analogues which is doc for myelodysplasia is |
Gemcitabines like Azocitabine Decitabine |
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Mc side effect of paclitaxel is |
Hypersensitivity |
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*Alkylating agents and their s/e Cyclophosphamide ifosfamide |
Siadh hemorrhagic cystitis |
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Alk agent procarbazine s/e |
Disulfiram like reactions with alcohol |
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Alk agent nitrosureas s/e |
Neutropenia |
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Alk agent busulfan s/e |
Pulmonary fibrosis |
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Mc mechanism of drug absorption is |
Passive diffusion |
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Drug efflux is a part of___ |
First pass metabolism |
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Acidic drugs maximally unionized in? |
Stomach |
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Basic drugs like amphetamine urine is acidified for excretion by? |
ammonium chloride |
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Fraction of unchanged drug that reaches systemic circulation is |
Bio availability |
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Normal range of bioequivalance is |
20% |
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Transdermal route is used only for drugs which are |
Highly lipid soluble |
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In case of oral route loading dose of drug depends upon three components? |
(Avd×c)÷F F bioavailability |
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Drugs with high avd are |
BAD DOC benzodiazepines Beta blockers Amphetamines Digoxin Opiods Ccbs |
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A person had benzodiazepines toxicity dailysis? |
No dialysis as benzodiazepines has high avd |
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Beta blockers toxicity antidote? |
Glucagon |
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All ACE inhibitors are prodrugs except |
Captopril Lisinopril |
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In phase II only reaction which is microsomal enzymes mediated |
Glucorinidation |
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Mc microsomal enzyme in phase II is ? |
Cytp450. 3A4 |
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Example of drug that metabolizes by glycination in phase II |
Nicotinic acid |
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Plasma protein bound drugs can be excreted by__ |
Secretion by kidneys |
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If a person lost 20mg/hr of drug in 5hours then maintanence dose is |
Rde × time 20×5 =100mg |
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In unparallel dose response curves __ cant be compared |
Affinity |
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If a drug binds to a target and no effect is produced then that drug receptor interaction is called |
Antagonist |
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Mc drug receptor antagonism is |
Competitive reversible antagonism |
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In allosteric or non competitive antagonism potency__and efficacy? |
Potency Remains same Efficacy decreases |
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5HT3receptor is __ subtype |
Ligand gated ion channel receptor |
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Prolactin and cytokine receptors are ___receptors |
Jak receptors |
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Subtype receptors Her 2 Estrogen |
Her2enzymatic receptor Estrogen nuclear receptor |
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Beta 2receptors stimulates MLCP in smooth muscle so result is |
Dec in contractions |
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Beta 2receptors ___ in skeletal and cardiac muscles |
Increases contractions |
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Gq type of receptors increase in ___ enzyme |
Phophlipase C |
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Gs type of receptors stimulates __ enzyme |
Adenylate cyclase |
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In PNS M2receptors are___ type of G receptors |
Gi/o type |
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G12/13 stimulates ____ enzyme |
Rhokinase |
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Drug development permission for clinical trails is given by |
Gcp good clinical practice guidelines |
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Cpc sea guidelines gives permission to conduct |
Preclinical trails |
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Efficacy of drug with zero error is seen in___ trail |
Phase III |
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Effectiveness of drug is found in __ phase |
Phase IV trail |
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Pharmacovigilence ass with |
Adverse drug reactions |
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In this double reciprocal plot for enzyme inhibition D line indicates |
Uncompetitive inhibitor |
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Adrenals belong to sympathetic nervous system but the receptors are? |
Nn type of receptors |
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In AchE which site cleaves acetate and choline bond |
Esteric site |
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____ inhibits release of ach and help in rx of migraine |
Botulinum toxin |
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Nicotinic receptors are ___ subtype of receptor |
Ligand gated ion channels |
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Direct cholinergic amide which is doc for xerostomia is |
Cevemeline |
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Longer acting ach are __ __ has max nicotinic effect |
Carbochol high nicotinic Methacholine Bethanechol |
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In chOlinergic drugs poisoning antidote is ___ it has least effect on? |
Atropine least on carbechol |
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Organophosphates poisoning phosphates binds to___ site on achE |
Esteric site and block achE |
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Carbamate binds to __ site of achE |
Both esteric and anionic and it is slowly reversible |
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Doc for atropine toxicity is |
Physostigmine - crabamate |
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Doc for myasthenia grevis is |
Pyridostigmine -quaternary amine carbamate |
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Rivostigmine is teritiary amine __ soluble |
Un ionized lipid soluble |
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For cobra bite _ carbamate is used |
Neostigmine a quaternary lipid insoluble amine |
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Ach methacoline bethanachol are all ___ type of direct cholinergics |
Choline esters |
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Direct cholinergics which are amides are |
Pilocarpine Cevemiline |
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Indirect cholinergics are |
Organophosphates Carbamates |
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A organophophate used as mitotic agent in glaucoma is |
Echothiophate |
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Doc for narcoanalysis is |
Thiopental sodium |
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Anticholinergic used as cycloplegic in adults |
Tropicamide short acting |
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Anticholinergic used in general anesthesia is |
Glycopylorate |
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To decrease acid production__ anticholinergics used |
M1antagonists Telenzepine Pirenzepins |
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Anticholinergics and beta3receptor agonists are used in __ bladder condition |
Urge incontinence |
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Metyrosine inhibits ___ enzyme |
Tyrisone hydroxylase rate limiting enzyme |
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VMAT transporter is inhibited by |
Reserpine Tetrabenzine |
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Dopamine beta hydroxylase is inhibited by |
Disulfiram |
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Doc of huntingtons chorea is |
Tetrabenazine |
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Presynaptic sympathetic receptors are___ which are __ type |
Alpha2receptors Inhibitory type decreases insulin and cause hyperglycemia |
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Beta 3receptors are present on |
Bladder Adipocytes |
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Epinephrine a sympathimimetic drug is used in glaucoma 1°moa? |
Dec aqueous production |
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Endogenous catecholamines are |
Epi NE dopamine |
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Dopamine acts as diuresis at dose of |
0-2ug/dl |
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2-10 >10ug/dl of dopamine actions |
Cardiac contraction Vasoconstriction |
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Doc in cardiogenic shock is |
Dopamine |
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Exogenous catecholamine used in pharmacological stress testing |
Dobutamine |
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Exogenous catecholamine used in rx of brochial asthma is |
Isoproteronol |
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NE depletors at intermediate dose causes |
Sympathomimetic effect |
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NE depletor used as vasopressor of choice in pregnancy is |
Ephedrine |
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ADHD Tourettes syndrome without tics |
Methylphenidate |
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Tourettes syndrome with tics |
Atomoxetine Clonidine alpha2agonist Guanfacine |
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Guanethidine guanandril are NE depletors c/i in pts with? |
Pheochromocytoma |
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Doc of narcolepsy |
Modafinil |
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Alpha agonist in hypertensic emergency is |
Clonidine alpha 2vasodilator |
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Clonidine vasodilator so CO decreases and blood flow to brain decreases so used in rx of |
Migraine |
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Selective agoinist causing lid retraction is |
Apraclonidine |
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Rx of persistent bronchial asthma is |
Inhalational corticosteroids |
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Tolazoline a reversible alpha blocker used as |
Vasodilator in angiography |
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Intraoperative emergency pheochromacytoma alpha blocker of choice |
Phentolamine |
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Pre operative emergency in phemochromocytoma alpha blcoker given is |
Phenoxybenzamine |
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Alpha1a blockers are used in rxof |
Bph by prostatic urethra dilatation |
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Terazocin Doxizocin are alpha blockers used in |
Htn with bph |
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Tamsillocin silodosin __ are doc for? And side effect is? |
Alpha1a blockers Bph Retrograde ejaculation |
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Beta blockers are doc in 2conditions related to heart |
Hocm Aortic dissection |
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Timolol c/i in |
Brochial asthma |
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Oxprenolol is ___ type of beta blocker |
Non selective |
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Mc used beta blocker in chf is |
Carvedilol |
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Beta blocker niprodilol inc___ |
NO |
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Ezetomibe is used in hyperlipedimias moa? |
Dec absorption of cholesterol by inhibiting NPC1L1receptors |
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Niacin is used in control of hyperlipidemias by moa? |
Dec hsl harmone sensitive lipase so fats are not converted into fatty acids and dec hyperlipidemias |
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In intestine cholesterol absorbed by __ Cholesterol converted into esterified cholesterol by __ ___ breaks fats into fatty acids ___ protein helps in transport of tg to lipoprotein |
NPC1L1receptors Acat acyl coenzyme transferase Hsl harmone sensitive lipase Mtp macrosomal triglyceride transport protein |
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Mepe merson sodium is used for familial hyperlipidemias moa? |
Inhibits rna of apob100 |
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Pcsk 9 inhibitors inhibits__ |
Degradation of LDL receptors |
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Doc for type II hyperlipedemias is |
Statins |
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Longest acting statin is |
Rosuvastatin |
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Most potent statin is |
Petavastatin |
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Side effect of statins is__ absolutely c/i in |
Hepatotoxic Pregnancy and children<10years |
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Moa of bile acid binding resins is |
bile binding and dec bile so cholesterol used to form bile to increase cholesterol absorption ldl receptors increases so finally plasma ldl dec |
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Flushing is side effect in ___ drug for hyperlipedemias |
Niacin causes inc in pg |
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Fibrates usedin __ |
TypeIII hyperlipedemias |
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Fibrates competitively inhibit __ |
Statins |
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Doc for triglyceridemia is |
Fibrates |
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Ivabridine blocks __ Fda approved it for? |
Na k funny channels Chronic chf Stable angina |
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Rx of psvt is |
Adenosine |
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In rx of acute attacks ___drug is given before cardioversion |
K channel blocker ibutilide |
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Most arrhythmogenic class of na channel blocker is and eg |
Class Ic Fmpe Flecanaide Morcizin Propofone Eucainide |
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Procainamide na channel blocker has maximum __ effect |
Class Ia drug has max anticholinergic effect |
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Rxoc in wpw syndrome is |
Radiofrequency ablation |
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Wpw syndrome with atrial fibrillation rx is |
Iv procainamide |
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Long term mx of wpw syndrome by |
Oral flecainide |
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Antiepileptic used in digoxin induced ventricular tachycardia is |
Phenytoin |
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Doc in ventricular premature beats |
Beta blockers |
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Doc for vt vf af aflutter |
Amiodorone |
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Stable angina Monotherapy by |
Non DHP ccbs |
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Dhp ccbs and beta blockers combo given in |
Stable angina |
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Long Qt syndrome acute attacks is rx by |
Mgso4 |
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Digoxin causes av node block so used in |
Avnrt |
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In CHF doc for pul edema |
Furosemide |
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In CHF doc for dec LV contractions is |
Dobutamine |
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In cardiogenic shock + chf doc for dec lv contractions is |
Dopamine |
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Drugs used in acute heart failure syndrome are |
Shiba Spirinolactone Hydralazine Ivabridine Beta blockers Arbs ace - |
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Betablocker approved for acute chf |
Cbm compound ie Carvedilol Bisoprolol Metoprolol |
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Fda approved drug for chf which is bnp analogue is |
Nesiritide |
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Nesiritide is used in |
Acute chf + resistent pulmonary edema |
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Amrinone is a drug used in CHF it is ___ inhibitor |
Pde3 is phosphodiesterase 3 inhibitor |
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Delayed after depolarizations seen with ___ drug |
Digoxin |
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Mc digoxin induced arrythmias is |
Bigemini |
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Digoxin at high doses is __ so tachyarrhythmias seen |
Sympathomimetic |
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Xanthopsia is seenwith __ toxicity |
Digoxin |
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Doc for htn and raynauds phenomenon is |
Ccbs |
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Doc for htn emergency is |
Iv necardipine |
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Mc side effect of ccbs is |
Head ach |
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A vasodilator with drug induced sle as side effect |
Hydralazine |
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Example of k channel.opener and its use |
Minoxidil for resistent htn |
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Sildinafil inhibites phosphodiesterase 5 that inhibites c gmp so sildinafil is not given along with |
Nitrates |
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Doc for malignant htn |
Iv sodium nitroprusside |
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Angiotensin II acts on ___ arterioles in kidneys |
Efferent |
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Ace inhibitor which has uniphasic elimination is |
Captopril |
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____ace- helps in diagnosis of renovascular htn |
Captopril |
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Antihypertensives which has uricisuric effect is |
Arbs |
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Reserpine is___ inhibitor used as antihtn |
Peripheral neuronal inhibitor |
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Aliskerin is |
Direct renin inhibitor |
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Doc for htn urgency |
Clonidine |
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Betablockers c/i in ____ angina |
Variant |
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Fasudil is rheokinase inhibitor used for |
Angina |
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Alz ds mild to moderate rx is |
Donepezil |
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Severe alz ds rx? |
Memantine |
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Riluzole is doc for |
ALS |
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Which vit is c/i in parkinsons disease |
Vit b6 |
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Levodopa is combined with carbidopa as it prevents__ |
Peripheral decarboxylation |
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Doc in on and off phenomenon in parkinsons ds |
Entacapone COMT inhibitor |
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Doc for drug induced parkinsons ds is |
Benzhexol |
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__ergot alkoloid is a dopamine agoinist and peripheral vasoconstrictor its s/e |
Bromocreptine s/e retroperitoneal fibrosis |
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Doc for hyper prolactinemia a ergot alkaloid a dopamine agoinist |
cabergoline |
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A synthetic alkaloid a dopamine agonist used as transcranial route for parkinsons ds is |
Rotigotine |
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Amantidine is used in |
It nmda inhibitor Neuromalignant syndrome |
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Most potent antipsychotic is |
Haloperidol |
|
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Most potent antipsychotic of phenothiazine is |
Fluphenazine |
|
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Doc for extra pyramidal side effects rx is |
Anticholinergics |
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Doc for malignant hyperthermia and tardive dyskinesia is |
Dantrolene |
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Doc schizophrenia is |
Aripiprazole |
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Doc for resistent schizophrenia |
Clozapine |
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Max obesity is seen with__ antipscychotic |
Clozapine |
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Adhd with tourettes rx is snri? |
Atomoxetine it is snri |
|
|
Tca of choice in ocd is |
Clomipramine |
|
|
Antihistaminic drug used as tca is |
Doxepin |
|
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Tca used in cocaine dependence is |
Desipramine |
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This tca has D2blocking property so used in psychotic depression |
Amoxapine |
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Tca has alpha1blocking property so used in |
Ejaculation abnormality |
|
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Doc for depression Premenstrual symptoms Neurosis is |
Ssri |
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Longest acting ssri is |
Fluoxetine |
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Shortest acting ssri is |
Fluoxamine |
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Ssri shouldnt be given with____ becz it causes seritoinin syndrome |
Moa inhibtors |
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|
Doc in depression with insomnia |
Mirtazapine a tetracyclic antidepressant |
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Doc in depression and erectile dysfunction is |
Buproprion |
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Phenobarbital is ___ acting barbiturate |
Long |
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Barbiturate used in rx of criggler najjar syndrome is |
Phenobarbital |
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Antiepileptic causes acute intermittent porphyria as side effect is |
Barbiturates |
|
|
Remelton is melatonin agoinist used for |
Jet lag |
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In mania stimulation if beta catenin pathway results in___ of BDNF |
Decrease |
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Doc for acute mania |
Atypical antipscychotics |
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Doc in prophylaxis in bipolar disorder is |
Li |
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In unipolar depression this drug is used |
Li |
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Doc for rapid cyclers is |
Valproate |
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Diuretics when used along with Li it results in |
Li toxicity |
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Toxic dose of Li is |
>1.5mg/dl |
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___ produces hypnosis by acting on alpha1part of alpha subunit used as sleeping pills |
Z compounds |
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Bzd preferred for status epilepticus is |
Lorazepam |
|
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Clobazam a bzd used in rx of__ |
Catamanial epilepsy |
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|
Drugs that inhibits alcohol craving is |
Nota Naltrexone Ondonsetron Topiramate Acamprosate |
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Most potent semisynthetic opiod is |
Heroin |
|
|
Most potent opiod and opoid with max plasma protein binding |
Sufentanyl |
|
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Moa inhibitors use result in meperidine or pethidine to follow N dealkylation result in nor meperidine increase causes__ |
Neurotoxic- seizures |
|
|
Butarphanol is opoid acts agonist on kappa antagonist on u receptors given intranasally for |
Migraine |
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Doc for acute opoid toxicity is |
Iv nalaxone |
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Doc for opoid dependence to prevent relapse is |
Oral naltrexone |
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Most of anticonvulsants are enzyme inducers except__ |
Valproate |
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In absence seizure ___ channels are only involved |
Ca2+ Na not involved |
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In absence seizure ___ channels are only involved |
Ca2+ Na not involved |
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Doc in partial seizures is |
Carbamazepine |
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Lenox gastraut syndrome doc is |
Valproate |
|
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Phenytoin effect on blood glucose levels |
Hyperglycemia |
|
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Carbamazepine causes inc in ADH result in |
Dilutional hyponatremia |
|
|
Doc of epilepsy in pregnancy is |
Lamotrigine |
|
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Antiepileptic drug used for prophylaxis of migraine |
Topiramate |
|
|
Topiramate and phenteramine is used for rx of |
Obesity |
|
|
K channel opener ezogabine is used for rx of |
Partial seizures |
|
|
Infantile spasm with tuberous sclerosis rx is |
Vigabatrine |
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Sv2A inhibitor synaptic vesicular protein) is __ |
Leveteracetam |
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Peptide called glp1 released by epithelial cells acts on __ |
Glp1receptors on pancreas |
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|
Glp releases two harmones from pancreas which inhibits git contractions and result in postprandial hypoglycemia? |
Amyline |
|
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In kidneys glucose reabsorption is by ___ receptors |
Sglt |
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___ drugs used in prandial and postprandial hyperglycemia is |
Alpha glucosidase inhibitors |
|
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Dpp4inhibitor which cause max decrease in Hba1c |
Sitagliptin |
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|
Glp1agoinists of alpha glucosidase inhibitor route of administration is |
Subcutaneous |
|
|
Doc for DM type 1 |
Insulin |
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|
Insulin dose is reduced to 50% if it is used along with |
Amyline analogues like pramlinitide |
|
|
Neutral protamine H insulin is __ type of insulin |
Long acting |
|
|
Ex of ultra long acting insulin |
Glargine |
|
|
Iv route insulin are |
Regular insulin Aspart insulin |
|
|
Most potent sulfonyl ureas is |
Glibenclamide |
|
|
Obesity is s/e of which oral hypogylcemia drug |
thiozolidendiones |
|
|
Inhalational drug for postprandial hyperglycemia |
Afreeza |
|
|
Somatostatin decreases GH and __ |
Tsh |
|
|
Mecasermin rinfabate is ___ analogue |
Analogue of IGF1 |
|
|
Ixoc in acromegaly is |
Serum IGF1levels |
|
|
Pegvisomant is GH antagonist used in |
Acromegaly |
|
|
GH and somatostatin both are antagonist to |
Insulin |
|
|
__ oral hypoglycemic drugs absolutely c/i in renal and liver failure |
Sulfonyl ureas |
|
|
Gh analogues like somatrem somatropin are c/i in __ |
Diabetic retinopathy |
|
|
__ somatostatin analogue which is radiolabelled and used in__ |
Octreotide Pituitary adenoma Carcinoid syndrome |
|
|
Doc for Insulinoma |
Diazoxide |
|
|
Doc for Vipomas Glucagonomas |
Octreotide |
|
|
Doc for Vipomas Glucagonomas |
Octreotide |
|
|
Granirelix is __ |
Gnrh antagonist dec lh fsh |
|
|
Tamoxifen action on uterus |
Causes hyperplasia and cancer |
|
|
Ospemifene is approved for rx of |
Postmenopausal dyspareunia |
|
|
Doc in tomoxifene resistent breast ca |
Fluvestrant |
|
|
Clomiphene increases the risk of__ ca |
Ovarian |
|
|
Doc for er pr + breast cancer in postmenopausal women |
Aromatase inhibitor |
|
|
Aldosterone is __ |
Pure mineralocorticoid |
|
|
Most potent and longest acting steriods are |
Dexa and betamethsones |
|
|
In cushings syndrome steroids increases and switch off genes for ___ so lemon and stick appearance seen |
Glut4receptors |
|
|
In bone rank receptors present on |
Osteoclasts |
|
|
Osteoclasts produces ___ which inhibits osteoblasts |
Sclerostin |
|
|
Action of calcitonin |
Inhibits bone resorption |
|
|
Strontium ranalate is used in |
Resistent osteoporosis |
|
|
Bisphophonates are c/i in |
Renal failure |
|
|
In pregnancy hyperthyroidism doc in 1st tri 2nd tri |
Propyl thiouracil Methimazole |
|
|
Drugs which are___ inhibitors makes the patient euthyroid before surgery |
Thio endol peptidase like KI Lugols iodine |
|
|
Strongest antiplatelet drug is |
GpII b IIIa inhibitors -abciximab |
|
|
Fibrinolytic Activates only plasminogen bound to fibrin is |
Amistreplase |
|
|
1st generation cephalosporins ? Dr lo loin zoo |
Cefadroxin Cefalothin Cefaloridin Cefazoline |
|
|
Ankle edema is s/e of ___ influenza agent |
Amantidine -M protein inhibited drug |
|
|
Radioleucent renal stones by __ anti retroviral agent |
Indinavir |
|
|
Doc for tenia capitis is |
Griseofulvin |
|
|
Doc for liver flukes is |
Triclobendazole |
|
|
Doc for cryptosporidiasis is |
Nitazoxanide |
|
|
Amino penicillin against shigella salmonella is |
Amoxicillin |
|
|
Enterococcus feacalis drug used for tx |
Ampicillin |
|
|
Antibiotic for late stages of syphilis |
Aqueous penicillin G |
|
|
In beta lactamase producing organisms classD produces ___ enzyme |
Cloxacillinase |
|
|
Pencillinase resistent penicillin are Oral? Parentral? |
Oral oxicillin cloxicillin dicloxicilln Parentral naficillin methicillin |
|
|
Amoxicillin is____+____ |
Penicillin + clavulinic acid |
|
|
Avibactam +____ help in rx of abdominal infections |
Avibactam+ceftazidime |
|
|
Doc for vrsa |
Daptomycin |
|
|
Doc for surgical prophylaxis is |
Cefazoline |
|
|
Prophylactic antibiotic for colorectal surgeries |
Cefatetan>cefoxitin |
|
|
Longest acting sulphanomide is |
Sulfadoxime |
|
|
Resistance to acyclovir or gancyclovir doc |
Foscarnet |
|
|
Resistance to guanosine nucleoside analogues is due to __ mc mechanisim |
Increase thymidalate kinase |
|
|
Gancyclovir is used in tx of __ virus |
Cmv |
|
|
Antiviral drug which inhibits virus attachment is |
Docosanol |
|
|
In cmv retinitis ___ drug is given by ocular route |
Fomivirisen |
|
|
Doc for BK virus is And its moa |
Cidofovir Inhibits T kinase |
|
|
Anti influenza agent ie antihemagglutinin monoclonal ab |
Deridizumab |
|
|
Bird flu doc is |
Osltamavir -neuroaminidase inhibitor |
|
|
10kgbaby with bird flu doc is |
Oseltamavir 30mg 3mg/kgbwt |
|
|
Oseltamavir is good by oral Iv drug and inhalational for oseltamavir sensitive influenza is |
Iv permavir Inhalational laninamivir |
|
|
In lamivudine resistence this antihepatitic agent shows resistence? Doc? |
Entecavir shows resistence Tenofovir is doc |
|
|
RSV prophylaxis is |
Palivizumab monoclonal abs |
|
|
Ribavirin oral route against hepC and inhaltional route for |
RSV |
|
|
Agent used in tx of hepatitis C also can be given in acyclovir resistent herpes is |
Interferon alpha |
|
|
Mc side effect of zidovudine is |
Bone marrow suppression |
|
|
Abacavir is? |
Nucleotide reverse transcriptase inhibitor NRTI |
|
|
Didanosine a nrti s/e is |
Pancreatitis |
|
|
In hiv pregnancy in zlne which drug is c/i |
Efavirinz |
|
|
___ is booster by inc t1/2of lopinavir by cyp 3A4inhibiting |
Ritonavir |
|
|
All protease inhibitors causes dyslipedemias except |
Atazanavir |
|
|
Antifungal which has rna synthase inhibitor activity |
Taraborole |
|
|
Griseofulvin moa |
Inhibits microtubules |
|
|
Amphotericin B is given by Precautions? |
5%dextrose Preload with 1to2l of n saline to prevent nephrotoxicity |
|
|
Doc for coccidial meningitis is |
Fluconazole |
|
|
Doc for cryptococcal meningitis is |
Amphotericin B |
|
|
Doc for endemic mycosis |
Itraconazole |
|
|
Recent azole affinaconazole is for |
Fungal toe nail infection |
|
|
Except tenia capitis __ is doc for dermatophytes |
Terbinafin |
|
|
Fungal toe nail inf antifungal are |
Effiniconazole Taraborole |
|
|
Doc of fungal corneal ulcers is |
Natamycin |
|
|
Most hepatotoxic anti tb drug is |
Pyrazinamide |
|
|
In isoniazid action inhA gene is for ____ which helps tb bacilli in__ |
Protein carrier Mycolic acid |
|
|
With inh tx if ___ mutation occurs then it is called 'severe resistence |
Kat G gene |
|
|
Most of the side effects of inh is due to |
Crosses bbb and inhibits vit b6 |
|
|
If these side effects seen with rifampcin then it is stopped and not used |
Plt decreased Pulmonary syndrome |
|
|
Moa of H R Z E |
H- inhibits mycolic acid R-rna polymerase inhibitor Z-fatty acid synthase inhibitor E- inhibits arabinosin transferase |
|
|
Drug used for tx impotence is used as 2ndline tb drug |
Ethionamide |
|
|
In multibacillary leprosy ___ drugs given |
Rifampcin dapsone clofazimine |
|
|
Doc for kerion is |
Griseofulvin |
|
|
In DEC resistence filariasis __ is given |
Ivermectin |
|
|
Doc for intestinal forms of tenia solium is |
Praziquantel |
|
|
Pyrentel pamoate creates ____ in nematodes and used as treatment |
Spastic paralysis |
|
|
Piperazine creates __ in pathogenic parasite |
Flaccid paralysis |
|
|
Metronidazole is used for giardiasis but doc is |
Tinidazole |
|
|
Tinidazole resistent giardiasis is rx |
Nitazoxanide |
|
|
American trypnosomiasis is Doc? |
Chagas disease-benznidazole |
|
|
Wide spectrum drug is |
Niclosamide |
|
|
In chloroquine resistent vivax |
Act + primaquine 14days |
|
|
Chloroquine resistent falciparum |
Act + on 2ndday primaquine |
|
|
Act is? |
Artesunate 200mg Sulfadoxime pyramethamine |
|
|
Rxoc in pregnancy malaria is |
Quinine + clindamycin |
|
|
Bulls eye retinopathy is s/e of __ antimalarial agent |
Chloroquine |
|
|
Black water fever is s/e of __ antimalarial agent |
Quinine |
|
|
Except for malaria chloroquine is also used for |
Amoebiasis Giardiasis IMN |
|
|
Most potent antihistaminic is |
Des loratidine |
|
|
Histamine agonist used in control of vertigo is |
Betahistine |
|
|
Histamine receptor which mediates chemotaxis is |
H4 |
|
|
Histamine receptor which mediates inflammation and allergy is |
H1 |
|
|
For rx of bartter syndrome ___ is used |
Indomethacin |
|
|
Zileuton is used to prevent bronchoconstriction by moa |
5LOX inhibitor |
|
|
Irreversible inhibition of COX is by |
Aspirin |
|
|
____& indomethacin is given for closure of ductus arteriosus |
Aspirin |
|
|
Mefenamic acid had PG receptor antagonism and phospholipase a2 inhibition very useful in rx |
Dysmenorrhea |
|
|
___ is prodrug of pcm causes analgesic nephropathy |
Phenacetin |
|
|
First choice DMARD in RA is |
Methotrexate |
|
|
Sulfasalazine is metobolized into sulfapyridine rx in? and 5amino salicyclic acid rx in? |
Sulfayridine- RA 5aminosal- ulcerative colitis |
|
|
In RA joint destruction is due to a mediator called |
TNF ALPHA |
|
|
Longest and fastest acting 5HT 1B/1D |
Frovatriptan Rizatriptan |
|
|
____ drug keeps ductus arteriosis patent |
Alprostadil |
|
|
CA inhibitors c/i in |
Pts with liver cirrhosis |
|
|
Side effect of CA inhibitors is |
Metabolic acidosis |
|
|
Drug given in catamanial epilepsy is |
CA inhibitors |
|
|
Diuretic used in pulmonary edema is |
Heigh ceiling or loop diuretic |
|
|
Most potent loop diuretic is |
Bumetinide |
|
|
Loop diuretic that cause max ototoxicity is |
Ethacrynic acid |
|
|
Htn plus osteoporosis doc |
Thiazides as it causes ca reabsorption |
|
|
Diuretic of whose side effect is hyperuricemia |
Thiazides Loop diuretic |
|
|
Longest acting thiazides is Thiazides of choice in rx of htn |
Chlorthalidone |
|
|
Shortest acting thiazide |
Chlorthiazide |
|
|
Side effect of mannitol is |
Pulmonary edema |
|
|
Doc in cirrhotic edema is |
Spirinolactone |
|
|
Example of minerlocorticoid receptor antagonist is |
Eplerenone Spirinolactone |
|
|
Conivaptan Tolvaptan are |
Vasopressin 2receptor antagonists |
|
|
Doc in central diabetes insipidus |
Desmopressin v2receptor analogue |
|
|
Thiazides effect on free water clearance |
Decreases +ve free water clearance |
|
|
Nabilone and dronabinol cannabinoid receptor agonists |
