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14 Cards in this Set
- Front
- Back
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What is the function of atropine? |
1. Muscarinic cholinoceptor blocker - cholinesterase poisoning antidote 2. Lipid soluble - CNS effects |
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What is the function of bethanechol? |
1. Muscarinic receptor agonist - activates muscarinic receptors
"Bethany, call (bethanechol) me to activate your Bowels and Bladder" - increases tone of bladder or intestines |
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Atropine poisoning causes what effects? |
"Hot as Hell" (fever) "Red as beet " (flushing) "Dry as bone" (dry skin) "Blind as a bat" (pupil dilation) "Mad as a hatter " (hallucinations, psychosis) "The bowel and bladder lose their tone" (constipation, urinary retention) "The heart runs alone" (tachycardia) |
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Bethanechol poisoning causes what effects? |
Parasympathomimetic effects: diarrhea, urinary urgency, sweating, etc |
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What does neostigmine do? |
1. Cholinesterase inhibitor (Few CNS effects) 2. Myasthenia Gravis treatment 3. Reversal of neuromuscular blockade |
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Neostigmine poisoning causes what effects? |
DUMBELLS Diarrhea Urination Miosis Bradycardia, Bronchospasm Emesis Lacrimation Sweating, Salivation |
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Similar drugs to Neostigmine |
Pyridostigmine Physostigmine |
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Nicotine causes what effects? |
1. Nicotinic cholinergic receptor agonist 2. Used in smoking cessation |
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Nicotine toxicity has what effects? |
1. Dizziness, nausea, vomiting, sweating (mixed ANS effects) 2. Death due to respiratory muscle weakness |
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What is parathion, and what does it do? |
1. It's an organophosphate insecticide 2. It is a cholinesterase inhibitor DUMBELLSDiarrheaUrinationMiosisBradycardia, BronchospasmEmesisLacrimationSweating, Salivation |
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Name other organophosphates: |
1. Malathion 2. Sarin and Soman (nerve gases) |
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What is the antidote to organophosphate poisoning? |
Atropine + pralidoxime |
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Name three (3) inhibitors of cytochrome P450 enzymes |
1. Erythromycin 2. Grapefruit juice 3. Ketoconazole |
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Name three (3) inducers of cytochrome P450 enzymes |
1. Phenytoin 2. Rifampin 3. St. John's Wort |
