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19 Cards in this Set
- Front
- Back
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AMOXICILLIN |
Commonly prescribed with clauvanic acid (a beta lactamase inhibitor) Susceptible to betalactamase degradtion Binds to penecillin binding protein 1A located inside the bacterial cell wall. Opens the lactam ring Autolysins |
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CEPHELEXIN |
Minor wounds and lacerations effective against most gram positive bacteria beta-lactam Binds to PBPs inside the bacterial cell wall Autolysins |
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CEFACLOR |
BETA LACTAM Binds to PBPs inside the bacterial cell wall Autolysins |
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CEFIXIME |
Binds to PBPs inside the bacterial cell wall Autolysins |
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CEFEPIME |
Great activity against gram + amd gram - bacteria Disrupt synthesis of peptidoglycan layer of bacterial cell walls PBPs |
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CARBAPENEMS MEROPENEM |
Active against gram positive and gram negative bacteria Penetrates bacterial cells and interferes with synthesis of vital cell wall components which leads to cell death Penetrates cell wall to reach PBP targets |
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ERTAPENEM |
ACTIVE AGAINST GRAM POSITIVE AND NEGATIVE BACTERIA AND ANAEROBIC BACTERIA MEDIATED THROUGH BINDING TO PBPs |
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IMIPENEM |
BETA LACTAM GRAM POSIVTIVE AND NEGATIVE, ANAEROBIC BACTERIA COADMINISTRED WITH CILASTATIN BINDS TO PBPs |
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VANCOMYCIN |
SUBUNITS RNA SYNTHESIS |
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ANTIBIOTICS THAT INHIBIT PROTEIN SYNTHESIS
TETRACYCLINE |
BINDS TO 30S RIBSOME SUBUNIT PREVENTS TRNA FROM BINDING TO A SITE OF THE RIBSOME ALSO BINDS TO SOME EXTENT TO 50S SUBUNIT LEAKAGE OF NUCLEOTIDES |
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GENTAMYCIN |
BINDS TO 30S SUNUNITS OF RIBOSOMES CAUSING MISREADING OF TRNA AMINO ACIDS |
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STREPTOMYCIN |
AMINOGLYCOSIDE ANTIBIOTIC BINDS TO 30 SUBUNIT TRNA AMINO ACIDS |
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ERYTHROMICIN |
MACROLIE ANTIBIOTIC EXCRETED IN BREAST MILK PENETRATES CELL MEMBRANE, BINDS TO 50 SUBUNITS |
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Chloramphenicol
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TYPHOID FEVER BINDS TO BACTERIAL RIBOSOME INHIBITING PROTEIN SYNTHESIS LIPID SOLUBLE SO CAN DIFFUSE THROUGH CELL MEMBRANE BINDS TO L16 PROTEIN AND 50S SUBUNIT OF BACTERIAL RIBOSOMES. TRANSER OF AMINO ACIDS IS PREVENTED |
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Antibiotics inhibiting DNA biosynthesis Fluooroquinolones Ciprofloxacin |
antiinfective agent of the fluoroquinolone class
in vitro activity against a wide range of gram-negative and gram-positive microorganisms The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination. |
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Norfloxacin |
quinolone/fluoroquinolone antibiotic mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two he bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacterias. |
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Levofloxacin |
used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited. |
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Moxifloxacin |
quinolone/fluoroquinolone antibiotic. Moxifloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, active against both Gram-positive and Gram-negative bacteria. The bactericidal action of moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. |
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Antibiotics inhibiting RNA biosynthesis |
bactericidal activity against most gram-positive and gram-negative organisms well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF metabolized in the liver and eliminated in bile acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death. |
