Pharmacology

Front 1

What are the mechanisms for the following...
1) ASA
2) Clopidogrel/Ticlopidine
3) Abciximab

Back 1

1) acetylates COX -->arach acid-->TX2
which incr. glycoproteins on platelets and causes aggregation.
2) --<ADP receptors-->glycoprotein expression on platelets-->plate agg
3) Mab binds IIb/IIIa adherent factor to fibrinogen

Front 2

Drug that used for ACS that causes
1) neutropenia?
2) bleeding/thrombocytopenia
3) Gastric ulcer, Reye's Tinnitus

Back 2

1) Clopidogrel/ticlopidine
2) Abciximab
3) ASA

Front 3

Drugs tha tyou can use for ACS and stenting.

Back 3

1) Clopidogrel, Ticlopidine
2) Abciximab

Front 4

Drug used for fever, inflammation, pain control and first line for ACS.

Back 4

ASA

Front 5

Cancer drugs that inhibit DNA synthesis

Back 5

1) MTX 2) 5-Fu 3) 6MP

Front 6

Antimetabolite that stops
1) purine synthesis
2) Thymidine synthesis

Back 6

1) 6 Mercaptopurine
2) 5 Fu and MTX

Front 7

Drugs that can treat Leukemia and Lymphoma

Back 7

1) MTX
2) 6 MP (not CLL or Hodgkins)

Front 8

What besides cancer can MTX treat?
What cancers besides Leukemia and Lymphoma?

Back 8

1) juvenile/adult rheumatoid arthritis, 2) psoriasias
3) abortion/ectopic
4) choriocarcinoma/sarcoma

Front 9

Which drug has synergy w/MTX and what is it used to treat?

Back 9

1) 5FU
2) treats solid tumors, basal cell carcinoma, colon cancer

Front 10

Match the toxicity with the drug
1) Liver fatty change
2) Myelosuppression (reverese w/leucvorin)
3) myelosuppression (not reversible w/leucvorin)
4) photosensitivity rescue w/thymidine
4) mucositis
5) Bone marrow, GI, liver tox..?allopurinol incr. tox)

Back 10

1) MTX
2) MTX..inhibit THF..give back THF for help
3) 5FU
4) 5FU
5) MTX
6) 6 MP *Activate w/HGPRTase

Front 11

Which drugs alkylate DNA?

Back 11

1) Cyclophosphamide, ifosmafide
2) Nitrosureas; carmustine, lomustine, semustine, strptozocin
3) cisplatin, carboplatin
4) busulfan

Front 12

Which drugs intercalate into DNA?

Back 12

1) Doxorubicin, daunorubicin
2) Dactinomycin

Front 13

Which drugs disrupt DNA synthesis of mitosis?
1) free radicals?
2) ribonucleotide reductase block
3) Topo II agent

Back 13

1) Bleomycin (free radicals breaks DNA strands)
2) Hydroxyurea (ribonucleotide reductase blocker)
3) Etoposide block topo II and incr. DNA degradation

Front 14

Drugs that act on microtubules?

Back 14

1) Paclitaxel M phase agent binds tubulin and stablizies MT so Mitotic spindle cannot break down
2) Vincristine/Vinblastine M phase alkaloids that bind tubulin and MT polymerization

Front 15

Drug side effects
1) Megaloblastic anemia, leukopenia
2) myelosuppression, hemorragic cystitis
3) CNS (dizzy ataxia)
4) nephrotox and acoustic nerve damage
5) pulm fibrosis/pigmentation
6) cardio tox, myelosuppession, alopecia

Back 15

1) cytarabine
2) cyclosphosphamide, ifosfamide save w/mesna
3) nitrosureas/mustines
4) platins
5) Busulfan
6) Adriamycin, daunrubicin

Front 16

Which drugs alkylate DNA?

Back 16

1) Cyclophosphamide, ifosmafide
2) Nitrosureas; carmustine, lomustine, semustine, strptozocin
3) cisplatin, carboplatin
4) busulfan

Front 17

Which drugs intercalate into DNA?

Back 17

1) Doxorubicin, daunorubicin
2) Dactinomycin

Front 18

Which drugs disrupt DNA synthesis of mitosis?
1) free radicals?
2) ribonucleotide reductase block
3) Topo II agent

Back 18

1) Bleomycin (free radicals breaks DNA strands)
2) Hydroxyurea (ribonucleotide reductase blocker)
3) Etoposide block topo II and incr. DNA degradation

Front 19

Drugs that act on microtubules?

Back 19

1) Paclitaxel M phase agent binds tubulin and stablizies MT so Mitotic spindle cannot break down
2) Vincristine/Vinblastine M phase alkaloids that bind tubulin and MT polymerization

Front 20

Which drugs cause myelosuppression?

Back 20

1) Cyclophosphamide
2) Adriamycin, daurubicin
3) Dactinomycin
4) Hydroxyurea
5) Etoposide
6) Taxols and Paclitaxel

Front 21

Which drugs cause cardiotoxicity?

Back 21

1) adriamycin
2) Trastuzumab (Herceeptin) MaB Her2

Front 22

Which drugs cause pulmonary fibrosis?

Back 22

1) Busulfan
2) Bleomycin

Front 23

Which drugs treat Leukemia and Lymphoma?

Back 23

1) 6MP (not CLL or Hodgkins)
2) MTX
3) Cyclophosphamide (non-hodgkins')

Front 24

Which drugs treat CML?

Back 24

1) hydroxyurea
2) Busulfan
3) Imatinib

Front 25

Head to toe tumors and treatment
1) Brain
2) Breast
3) Lung
4) Gi
5) Ovarian
6) Testicular

Back 25

1) Nitrosureas
2) Cyclophosphamide, tamoxifen, trastuzumab, paclitaxol and other taxols
3) Etoposide
4) Imatinib
5)
6)paclitaxle and taxols,
5)Etoposide

Front 26

Kidney Cancer; Wilms, Ewings, rahbod?

Back 26

Dactinomycin

Front 27

Testicle cancer

Back 27

ciplatin, bleomycin, etoposide

Front 28

ovarian cancer

Back 28

1) paclitaxel, doxorubicin (br. ovary lung)

2) cisplatin (br. overy lung + testicle and blader)

3) cyclophosphamide (*breast and ovary)

Front 29

If you had breast, ovary or lung cancer which drug would you want and why?

Back 29

cisplatin; nephro and acoustic nerve damage

Adria; cardiotox, alopeica, toxic extravasation

3) paclitaxel; meylo supress, hypersensitivity
...i'd go w/the taxols if they were equally effective.