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186 Cards in this Set
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- 3rd side (hint)
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Trastuzumab
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mAb inhibitor EGFR2 (Her2/neu)
** Indications: 1st line for met breast CA Her2/neu+ ** SFx: fever pain chills |
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Gefitinib
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EGFR TK inhibitor
** Indications 3rd line met lung CA Salvage therapy breast CA |
EGFR
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Erlotinib
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EGFR TK inhibitor
*Indications 3rd line met lung CA salvage for breast CA *SFx N/V/D Skin rash Weight loss |
EGFR
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Cetuximab
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mAb inhibitor of EGFR
* Indications 3rd line lung CA salvage for breast CA * SFx N/V/D Weight loss Skin rash |
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Daunorubucin
Doxorubicin |
DNA Intercalators that inhibit Topo II
* Limiting toxicity: Bone marrow failure Cardiotoxicity |
Anthracycline class
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Methotrexate
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Inhibitor of FH2 --> FH4 synthesis
(tetrahydrofolate for thymidine synthesis) * Limiting toxicity: Marrow failure acute renal failure CNS encephalopathy *Resistance mech: reduced uptake reduced polyglutamylation increased DHFR repeats increased thymidylate synthetase |
Antifolate agent
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Vincristine
Vinblastine Taxol |
Tubulin-binding
* Limiting Toxicity: Neuropathy SIADH (VCR/VBL) * Resistance: Altered tubulin |
Alkaloids
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Cisplatin
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Alkylating agent
(cx link, ss/ds break) * Limiting toxicity: Renal ovulation and sperm ATN ototoxicity * Resistance: increased glutathione increased metallothionein |
Like cyclophosphamide.
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Cyclophosphamide
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Alkylating agent
(cx link, ds/ss breaks) * Limiting Toxicity: Renal sperm and ovulation hemorrhagic cystitis bladder fibrosis SIADH |
Like cisplatin.
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Bleomycin
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Induction of ss/ds breaks
* Indications: Cancer * SFx subacute pneumonitis * Resistance: Bleomycin hydroxylase |
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L-Asparaginase
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Inhibits Asn --> Asp + NH3
(tumor specific) * Indications: Acute lymphoblastic lymphoma * SFx Hypersensitivity Pancreatitis Hepatotoxicity |
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5-Fluorouracil
(5FU) |
Uracil analog
* Limiting toxicity: marrow failure |
Nucleotide analog
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3'-azido-3'-deoxythymidine
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Nucleotide analog
* Limiting tox: marrow failure |
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Cytosine arabinoside
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Nucleotide analog
* Limiting toxicity: marrow failure |
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5-azacytidine
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Nucleotide analog
* Limiting tox: marrow failure |
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6-mercaptopurine
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Purine analog
Limiting tox: marrow failure cholestatic jaundice |
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6-thioguanine
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Purine analog
* Limiting toxicity: marrow failure |
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Imatinib
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BCR-Abl TK inhibitor
Also inhibits SCF, PDGF, c-kit * Indications: Philadelphia chromosome+ CML (9:22) c-kit+ GI stromal tumor * SFx N/V/D Edema Cramps Heartburn |
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Rituximab
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mAb CD20 binding
induces ADCC *Indications: CD20+ refractory B cell non-Hodgkin's lymphoma * SFx: fever chills thrombocytopenia neutropenia |
anti-B cells
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Bortezomib
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26 S proteasome inhibitor
* Indications: Multiple myeloma * SFx: fatigue N/V/D fever thrmobocytopenia |
BORat's (Evgeniy's) favorite
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Bevacizumab
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mAb VEGF inhibitor
* Indications: 1st line met colorectal CA (with 5-FU) * SFx: Bowel perf & hemorrhage impaired wound healing |
Folkman.
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NO
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Induces guanylate cyclase
SM relaxation * Indications Neonatal RDS Acute RDS * SFx vasodilation if given systemically |
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Benzodiazepines
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Allosteric GABA-A
(c = 1/2-1/3 for Lo ~ 50k) * SFx Respiratory depression * Reversal: Flumazenil |
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Barbiturates
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Allosteric GABA-A
(>> BZ) * SFx (worse) respiratory depression |
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Flumazenil
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Competitive inhibor at BZ site on GABA-A
* Indications reversal of BZ * SFx withdrawal in dependency |
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Alpha 1 Adrenergic
Actions |
Vascular SM -- Contraction
Genitourinary SM -- Contraction Heart -- Contractility Liver -- Glycogenolysis Intestinal SM -- Relaxation |
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Alpha 2 Adrenergic
Actions |
Vascular SM -- Contraction
Platelets -- Aggregation Nerve -- ↓NE Pancreas -- ↓Insulin |
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Beta 1 Adrenergic
Actions |
Heart:
↑Ionotropy ↑chronotropy ↑AV conduction Renal: ↑Renin |
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Beta 2 Adrenergic
Actions |
Liver --
↑Glycogenolysis ↑Gluconeogenesis Skeletal Musc: ↑Glycogenolysis Adipose tissue: ↑lipolysis SM -- Relaxation |
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Isoproterenol
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Nonselective Beta Agonist
* Indications: Asthma * SFx Hypotension Tachycardia ↑Chronotropy |
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Dobutamine
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Beta 1 selective agonist
* Indications Bridge therapy in end-CHF * SFx Increased arrhythmia risk |
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Propranolol
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Nonselective Beta Blocker
* Indications CHF HTN Glaucoma * SFx Asthma exacerbation CNS sedation ↓Libido |
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Timolol
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Nonselective Beta Blocker
* Indications CHF HTN Glaucoma * SFx ↓Libido Asthma Exacerbation CNS Sedation |
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Prazosin
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Selective Alpha 1 Blocker
* Indications HTN CHF * SFx Postural hypotension Syncope |
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Clonidine
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Alpha 2 Agonist (CNS)
(Paradoxical! Recall ↓NE in nerves) * Indications Glaucoma HTN * SFx Dry mouth Sedation Bradycardia |
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-Caine family local anesthetics
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Ester Local Anesthetic (e.g. procaine)
Amide Local anesthetics (2 I's e.g. procainamide, lidocaine) ↑ efficacy IF: Increased Lipophilic R groups Charged quaternary amine ↑ penetration Uncharged tertiary amine |
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Phenelzine
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MAO Inhibitor
* Indications Depression Parkison's * SFx "Serotonin surge" Restlessness tremors seizures |
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Tyramine
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Uptake by VMAT to displace vesicular neurotransmitter
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Imipramine
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Inhibit NET
(NE and 5HT; ? DA) * Indications Depression * SFx Postural hypotension Sinus tachycardia ** P450 ** |
Tricyclic Antidepressant
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Desipramine
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NET Inhibitor
(5HT and NE) * Indications: Depression * SFx: Anticholinergic (dry mouth, cardiac, somnolence) Sedation |
Tricyclic
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Clomipramine
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NET Inhibitor
* Indications: Depression |
TCA
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Amitriptyline
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NET inhibitor
(5HT and NE) * Indications: Depression * SFx: Anticholinergic: dry mouth, cardiac Sedation |
TCA
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Cocaine
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NET Inhibitor
* Indications Local anesthetic Vasoconstrictor |
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Methamphetamine
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(1) Displacement of neurotransmitters like tyramine
(2) Inhibit MAO (3) Direct alpha and beta agonists * Indications: Stimulant * SFx ↑BP Restlessness/Agitation Dizziness/Tremor Erectile dysfunction |
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Ephedrine
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(1) Displacement of neurotransmitters (Tyramine)
(2) MAO Inhibitor (3) alpha and beta agonist * Indications: Nasal decongestant Anti-appetite |
Amphetamine
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Methylphenidate
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(1) Displacement like tyramine
(2) MAO Inhibitor (3) alpha and beta agonist * Indications ADHD * SFx HTN Restlessness/Agitation Dizziness/Tremor Erectile dysfunction |
Amphetamine
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Reserpine
(dose dependent) |
*Irreversible* VMAT Inhibitor (DA, NE, 5HT)
Low dose: degradation by MAO High dose: overwhelm MAO * Indications: HTN (low dose) Psychosis (high dose) * SFx Transient sympathetic psychotic depression |
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Pancuronium
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nAChR antagonist
* Indications Nondepolarizing paralytic * Reversal: AChE Inhibitors |
Like tubocurare
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Tubocurare
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nAChR antagonist
* Indications: Nondepolarizing paralytic * Reversal: AChE Inhibitors |
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Scopolamine
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mAChR antagonist
* Indications Anti-emesis * SFx Altered mental status |
Remember the Vomit Comet?
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Atropine
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mAChR antagonist
* Indications: Pupil dilation Reverse organophosphates Reverse sinus-bradycardia Dry mouth Inhibit vagal reflexes |
Remember The Rock?
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Succinylcholine
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nAChR agonist
* Indications Depolarizing paralytic |
Sux.
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Pilocarpine
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mAChR agonist
* Indications Glaucoma (Miotic) Xerostomia (↑saliva) |
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Carbachol
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mAChR agonist
* Indications Glaucoma (mitotic agent) |
CarbaCHOL(ine)
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Methacholine
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mAChR agonist
* Indications Vasodilation Vagomimetic "Diagnosis of Asthma" |
*M*etha *Choline*
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Neostigmine
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AChE Inhibitor
* Indications Glaucoma Myasthenia gravis Eaton-Lambert Syndrome (like MG against Ca channels) Abd distension |
Pancuronium reversal.
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Botunlinum Toxin
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AB inhibitor of synaptobrevin
(vesicle fusion) * Indications Flaccid paralyzing agent Wrinkle relaxation |
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Tolcapone
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COMT Inhibitor
(L-DOPA --COMT--> 3-O-MD) * Indications Parkinson's Dz * SFx Fulminant hepatic failure CNS + Peripheral effects |
Like Entacapone
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Entacapone
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COMT Inhibitor
(L-DOPA --COMT--> 3-O-MD) * Indications: Parkinson's Dz More peripheral than Tolcapone |
Like Tolcapone
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Chlorpromazine
(Thorazine) |
D1-D5 Receptor Inhibitor
* Indications Psychosis Nausea * SFx Parkinsonism Tardive dyskinesia Extrapyramidal: 1+ Sedation: 3+ |
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Thioridizine
(Mellaril) |
D1-D5 Receptor Inhibitor
* Indications: Psychosis * SFx Tardive dyskinesia Parkinsonism Extrapyramidal: 1+ Sedation: 3+ |
Most similar to thorazine.
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Thiothixine
(Navare) |
D1-D5 receptor antagonist
* Indications: Psychosis * SFx Tardive dyskinesia Parkinsonism Extrapyramidal: 2+ Sedation: 2+ |
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Haloperidol
(Haldol) |
D1-D5 Receptor Antagonist
* Indications Psychosis * SFx Tardive dyskinesia Parkinsonism Extrapyramidal signs: 3+ Sedation: 1+ |
Best associated with TD
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Clozapine
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Most selective D4 antagonist
* Indications Psychosis * SFx "many" Neutropenia (agranulocytosis) |
Atypical antipsychotics
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Risperidone
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Less selective D4 Antagonist
* Indications: Psychosis * SFx Neuroleptic malignant syndrome Tardive dyskinesia Weight gain |
Atypical Antipsychotic
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Olanzepine
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5HT2 and D2 antagonist
* Indications Psychosis Mania * SFx Tardive dyskinesia Extrapyramidal effects Weight gain Neuroleptic malignant syndrome **P450 Metabolism** |
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Phenytoin/Fosphenytoin
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? Na Channel Inhibitor
* Indications Epilepsy Mania * Acute SFx Nystagmus Ataxia Diplopia Sedation * Chronic SFx Hirsutism Gingivial hyperplasia peripheral neuropathy ** TERATOGEN ** ** 0-order kinetics ** |
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Valproic Acid
Valproate |
?
* Indications Epilepsy Mania * SFx Tremor Weight gain Nausea ** TERATOGEN ** |
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Carbamazepine
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? Na Channel Inhibitor
* Indications Epilepsy Mania * SFx Ataxia Diplopia Sedation ** Aplastic anemia ** TERATOGEN ** |
Like phenytoin
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Salicylates
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Mixed Cox-1 Cox-2 Inhibitor
* Indications Analgesia (E2) Inflammation (I2, E2) Pyrexia (E2 in thalamus) Thrombosis (TxA2) * SFx CNS: h/a, confusion, tinnitus Hepatic: LFTs, Reye's, hepatitis Nephro: Creat, nephrotic Heme: rare dyscrasias |
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Indomethacin
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Mixed Cox-1 Cox-2 Inhibitor
* Indications Pyrexia (E2) Analgesia (E2) Inflammation (I2, E2) Thrombosis (TxA2) * SFx: CNS: tinnitus, confusion, H/A Hepatic: Reye's, hepatitis Neprho: ↑Creat, Nephrotic Heme: Dyscrasia (rare) |
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Ketorolac
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Both Cox-1 and Cox-2 Inhibition
* Indications Inflammation (E2, I2) Pyrexia (E2) Analgesia (E2) Thrombosis (TxA2) * SFx CNS: HA, confusion, tinnitus Hepatic: Reye's, hepatitis Nephr: ↑Creat, nephrotic Heme: rare dyscrasias |
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-Coxibs
(Rofecoxib, Valdecoxib, Celecoxib) |
Selective Cox-2 Inhibitor
* Indications Inflammation (E2, I2) Analgesia (E2) * SFx increased thrombosis due to unopposed I2 inhibition |
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Carbidopa
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DOPA decarboxylase inhibitor
* Indications Parkinson's Dz with L-DOPA Uptake Dependent on GI Acid and Amino Acid intake |
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D1 vs. D2 in Parkinson's Dz
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Final Common:
Inhibit GPi which inhibits thalamus (net increase in thalamus) D1: activation of striatum which inhibits GPi D2 inhibition of striatum which inhibits GPe which inhibits STN which activates GPi. Wow. |
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Bromocriptine
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D1-D5 Agonist
* Indications Prolactinoma * SFx NVD Hypotension Psychosis Dyscrasias |
Like Pergolide
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Pergolide
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D1-D5 Agonist
* Indications Parkinson's Dz Prolactinoma * SFx NVD Hypotension Dyskinesias Psychosis/Sedation |
Like bromocriptine
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Trazodone
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NET Inhibitor
(NE and 5HT) * Indications: Depression * SFx Anticholinergic: dry mouth, cardiac Sedation Priapism =) |
TCA
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Fluoxetine
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SSRI
* Indications: Depression * SFx Tremor ? Suicide Contraindicated with MAO |
Like Paroxetine, sertraline, citalopram.
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Sertraline
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SSRI
* Indications: Depression * SFx ? Suicide Tremor Contraindicated with MAO |
Like Paroxetine, fluoxetine, citalopram
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Citalopram
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SSRI
* Indications: Anxiety Depression * SFx ? Suicide Tremor Contraindicated with MAO |
Like paroxetine, fluoxetine, sertraline
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Paroxetine
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SSRI
* Indications Depression Anxiety * SFx: Tremor ? Suicide Contraindicated with MAO |
Like fluoxetine, sertraline, citalopram
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Bupropion
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NE and DA reuptake inhibitor
* Indications * Depression Tobacco addiction * SFx * Seizures Hallucinations |
Atypical Antidepressant
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DA and NE synthesis
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Tyr --tyrosine hydroxylase -->
L-DOPA --DOPA carboxylase--> DA --DA beta hydroxylase--> NE |
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Serotonin (5HT) Synthesis
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Tryptophan --TP hydroxylase-->
5-OH-TP --DOPA carboxylase--> Serotonin (5HT) |
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Class Ia Antiarrhythmic
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Na block with some K+ block
Quinidine Procainamide |
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Class Ib Antiarrhythmic
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Derease repolarization time
Lidocaine |
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Class Ic antiarrhythmic
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Purest Na block
Encainamide |
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Class II Antiarrhythmic
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Beta blockers
Propranolol Atenolol |
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Class III Antiarrhythmic
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K+ blocker
Amiodarone |
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Class IV Antiarrhythmic
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Ca2+ Blocker
Verapamil Diltiazem |
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Digitalis
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Na/K ATPase inhibitor
(effect to increase Ca) Decreases conduction through AV node |
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Glucocorticoids
Immunomodulatory effects |
T lymphocyte depletion
Monocytopenia Eosinopenia ↑Neutrophils |
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Glucocorticoids Findings
Endocrine, Ophtho, GI, Psych, Derm |
Endocrine: ↑glucose, ↑obesity, hirsutism
Psych: Mood and Psychosis Ophtho: cataracts and glaucoma GI: pancreatitis Derm: Fragile skin |
Cushing's
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Glucorticoids in order of potency and duration
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Cortisol 1X
Prednisone 4X Methylpredinisone 5X Dexamethasone 30X |
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Etanercept
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Soluble TNFR
* Indications * RA Psoriatic arthritis Ankylosing spondylitis Psoriasis * SFx * Opportunistics (TB, aspergillus, PCP, Listeria) Lupus-like syndrome Aplastic anemia (rare) |
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Infliximab
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mAb TNF binding
* Indications * RA along with methotrexate Crohn's Dz Ankylosing spondylitis * SFx * Opportunistic Infections (aspergillus, PCP, Listeria, TB) Lupus-like effects Aplastic anemia (rare) |
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Adalimumab
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mAb binding TNF
* Indications * RA with MTX Ankylosing spondylitis Crohn's Dz * SFx * Opportunistic Infections (aspergillus, TB, PCP, Listeria) Aplastic anemia (rare) Lupus-like syndrome |
Like infliximab
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Anakinra
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Recombinant IL-1r
* Indications * RA |
Only one available in many ways
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Cyclosporine
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Binds immunophilin to inhibit Calcineurin
* SFx * Nephrotoxicity (requires mannitol diuresis) Neurotoxicity Neoplasms (??!) HTN ↑K+ Hirsutism Hyperglycemia Hyperlipidemia |
Almost like tacrolimus
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Tacrolimus
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FK506 binding inhibitor of cacineurin
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10-100 x more powerful than cyclosporine
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Azathiopurine
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6 Mercaptopurine not substrat for ADA --> acumulation of purines in lymphocytes
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rememeber ADA- SCID
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Mycophenolate mofetil
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mycophenolic acid ihibits inosine monophosphate dehydrogenase
(required for guanine synthesis) |
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Leflunomide
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Inhibito of dihydro-oroate dehydrogenase
(required for pyrimidine synthesis) |
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Anti-Lymphocyte Globulin
Anti-Thymocyte Globulin |
Polyclonal Ab against TCR/CD3
* SFx * Anaphylaxis Serum sickness Glomerulonephritis |
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OKT3
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Murine mAb against TCR/CD3
* SFx * Fever Myalgia Arthralgia GI Irritation |
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Sirolimus
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Inhibits mTOR, required for IL2-dependent G1 --> S transition
Also a macrolide antibiotic * SFx * hyperlipidemia HTN Hypokalemia Pancytopenia |
aka Rapamycin
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Daclizumab
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murine mAb against CD25
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Basilizimab
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Chimeric murine/human mAb against CD25
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Like Daclizumab
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Vesamicol
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Inhibits H+/ACh antiport
(Vesicle accumulation) |
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Omeprazole
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Irreversible H/K ATPase inhibitor
(by S-S requires 2 per ATPase) * Indications * Zollinger-Ellison GERD Ulcers * SFx * Elevated infection risk Bezoars ** P450 Inhibitor ** |
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Pyrilamine
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H1 Antagonist
mAChR Antagonist * Indications * Inflammation (H1) Emesis (mAChR) Runny nose (mAChR) Sedation (mAChR) Cough (mAChR) * SFx * Sedation Dry mouth Long QTc ** P450 Inhibitor ** |
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Chlorpheniramine
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H1 Antagonist
mAChR antagonist * Indications * Inflammation (H1) Emesis (mAChR) Cough (mAChR) Sedation (mAChR) Runny nose (mAChR) * SFx * Sedation Dry Mouth Blurred vision Long QTc ** P450 Inhibitor ** |
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Meclizine
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H1 Antagonist
mAChR Antagonist * Indications * Inflammation (H1) Cough (mAChR) Emesis (mAChR) Runny nose (mAChR) Sedation (mAChR) * SFx * Sedation Dry mouth Blurry vision Long QTc ** P450 Inhibitor ** |
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Cyclizine
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H1 Antagonist
mAChR Antagonist * Indications * Inflammation (H1) Cough (mAChR) Runny nose (mAChR) Sedation (mAChR) Emesis (mAChR) (Especially) * SFx * Sedation Blurry Vision Dry mouth Long QTc ** P450 Inhibitor ** |
Like meclizine
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Phenergan
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H1 Antagonist
mAChR Antagonist Fewer CNS fx due to ↓DA activity * Indications * Emesis (mAChR) (Especially) Cough (mAChR) Runny nose (mAChR) Inflammation (H1) * SFx * Dry Mouth Long QTc ** P450 Inhibitor ** |
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Fenofexidine
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Selective H1 Antagonist
* Indications * Inflammation (Allergies) Note: active metabolite of terfenidine without QTc issues |
Allegra
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Loratidine
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Selective H1 Antagonist
* Indications * Inflammation (Allergies) * Note: * No QTc issues few CNS issues |
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Cimetidine
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H2 Antagonist
* Indications * GERD Ulcers (gastric and duodenal) zollinger-ellison * SFx * Bezoars Infection CNS depression ** P450 Inhibitor ** |
Like ranitidine and famotidine
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Ranitidine
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H2 Antagonist
* Indications * GERD Duodenal and Gastric ulcers Zollinger-Ellison * SFx * Bezoars Infection ** P450 Inhibitor ** |
Like cimetidine and famotidine
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Famotidine
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H2 Antagonist
* Indications * GERD Zollinger-Ellison Gastric and Duodenal Ulcers * SFx * Bezoars Increased infection risk ** P450 Inhibitor ** |
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Gemfibrozil
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Fibrate PPARalpha Agonist
(↑Hormone Sensitive Lipase, Catabolism of VLDL, ↓LDL production, ↓FFA) * Indications * Hyperlipidemia inc. TG Dysbetalipoproteinemia * SFx * GI Distress Cholelithiasis Myositis Albumin Interaction |
GemFIBROzil
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Fenofibrate
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Fibrate PPARalpha Agonist
(↓LDL, ↓FFA, ↑VLDL catabolism, ↑hormone sensitive lipase) * Indications * Hyperlipidemia (TG) Hypercholesterolemia Dysbetalipoproteinemia * SFx * GI Distress Myositis Cholelithiasis Albumin interaction |
FenoFIBRATE
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Niacin
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Inhibits hormone sensitive lipase
(↓FFA, ↓LDL, ↓TG, ↓Lp(a), ↑HDL) * Indications * Hyperlipidemia Hypercholesterolemia * SFx * Pruritis H/A Flushing Hyperglycemia ** Gout GI Bleeding Liver problems |
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Sitostamol-Ester
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?? Cholesterol Absorption Inhibitors
* Indications * Hypercholesterolemia * SFx * none? |
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Colesevelam
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? Cholesterol Absorption Inhibitor
* Indications * Hypercholesterolemia * SFx * none? |
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Ezetimibe
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? Cholesterol Absorption Inhibitor
* Indications * Hypercholesterolemia * SFx * none? |
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Cholestyramine
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Anion-exchange Bile Acid Binding Resin
* Indications * Hypercholesterolemia * SFx * Bloating Constipation Abdominal Discomfort Decreased absorption of lipid drugs |
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Colestipol
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Anion-exchange Bile Acid Binding Resin
* Indications * Hypercholesterolemia * SFx * Adominal Discomfort Decreased drug absorption Constipation Bloating |
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Statins
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HMG CoA Reductase Inhibitors
* Indications * Hyperlipidemia * SFx * Toxicity with Triazole antifungal agents Rare rhabdomyolysis |
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Hydrochlorothiazide
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Inhibits Na and Cl uptake in the distal tubule
* Indications * HTN Calcium reuptake Neprhogenic DI (good to lose salt and induce RAA system, and DCT drugs do not affect main CD gradient) * SFx * Hypokalemia |
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Captopril
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ACE Inhibitor
* ACE Roles * AT-I --> AT-II and reduced bradykinin * Indications * HTN * SFx * 5-10% Dry Cough (use -sartan ARB) |
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Enalapril
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ACE Inhibitor
ACE Roles: (ATI --> ATII, and decreases bradykinin) * Indications * HTN * SFx * 5-10% cough |
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Lisinopril
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ACE Inhibitor
* ACE Roles * ATI --> ATII decreases bradykinin * Indications * HTN * SFx * 5-10% Cough (use -sartan ARB) |
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-Sartans
Losartan Valsartan Irbesartan etc. |
Angiotensin II Receptor Blocker
(no bradykinin effect) * Indications * HTN * SFx * Hyperkalemia |
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Spironolactone
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Inhibitor of Na/K ATPase
(K+ sparing) * Indications * K+ sparing diuresis |
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Furosemide
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Inhibitor of Na/K/2Cl coport
* Indications * HTN * SFx * Hypokalemia Hypocalcemia |
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Metaproterenol
|
B2 Selective Agonist
* Indications * Asthma |
Like Albuterol
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Albuterol
|
B2 Selective Agonist
* Indications * Asthma |
Like... albuterol.
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Salmeterol
|
B2 Selective Agonist
Long-acting * Indications * Asthma |
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Flutamide
|
Androgen receptor inhibitor
* Indications * Prostate CA |
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Sorafenib
|
"Multikinase inhibitor"
(Tyr and Ser/Thr) * Indications * Renal Cell CA |
-nib
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Leuprolide
|
GnRH Analogue
* Indications * Adv. Prostate CA ** Breast CA Endometriosis Fibroids Precocious puberty IVF ovarian stimulation |
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Fentanyl
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Opiod
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Naloxone
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Mu opiod antagonist
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Naldolol
|
Nonspecific Beta Blocker
(long half life) |
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Labetalol
|
Alpha 1, Beta blocker
* Indications * Pheochromocytoma |
(recall danger of unbalanced beta block)
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Alprostadil
|
Prostaglandin E1
(vasodilator) * Indications * Erectile dysfunction |
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Epoprostenol
|
Prostaglandin I2
(Vasodilator) * Indications * Pulmonary HTN |
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Latanoprost
|
Prostaglandin F2a
* Indications * Glaucoma (aq humor outflow) |
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Misoprostol
|
Prostaglandin E1
* Indications * NSAID gastric and duodenal ulcers |
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Dinoprostone
|
Prostaglandin E2
* Indications * Cervical dilation Uterine contraction |
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Ticlopidinie
|
ADP/platelet binding inhibitor
* Indications * Antithrombosis (synergistic with aspirin) |
Like clopidrogrel
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Clopidogrel
|
ADP/thrombocyte binding inhibitor
* Indications * Antithrombosis (synergistic with salicylates) |
Like ticlopidine
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Alteplase
|
Plasminogen activator
* Indications * Thrombolysis |
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Eptidfibatide
|
GP IIb/IIIa inhibitor
* Indications * Antithrombosis |
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Indapamide
|
Thiazide diuretic
* SFx * Hyperuricemia |
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Minoxidil
|
? K+ Channel Antagonist
? nitrate * Indications * HTN Hair loss |
Rogaine
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Alosetron
|
5-HT3 antagonist
* Indications * "Diarrhea" irritable bowel syndrome |
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Domperidone
|
D2 Receptor Antagonist
* Indications * "Prokinetic Agent" ? Parkinson's Dz |
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Dronabinol
|
Cannabinoid
* Indications * Nausea control in chemotherapy |
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Lansoprazole
|
Proton pump inhibitor
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Phentermine
|
Amphetamine derivative
* Indications * Appetite control |
Phen-Fen
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Sulfasalazine
|
Sulfa + Salicylate
* Indications * Ulcerative Colitis |
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Ursodiol
|
Cholesterol Dissolving Agent
* Indications * Cholesterol Gallstones |
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Propylthiouracil
|
Thyroid Peroxidase Inhibitor
* Indications * Hyperthyroidism |
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Procainamide
|
Class IA Antiarrhythmic
* Indications * Ventricular arrhythmia * SFx * Lupus-like syndrome ** Agranulocytosis Bone marrow depression |
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Disopyramide
|
Class IA Antiarrhythmic
* Indications * Ventricular arrhythmia * SFx * Atrial tachyarrhythmia Heart block Conduction abnormalities |
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Flecainide
|
Class IC Antiarrhythmia
* Indications * Ventricular Arrhythmia (life-threatening) * SFx * Paresthesias Ataxia Flushing Vertigo Tinnitus Depression |
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Mexiletine
|
Class Ib Antiarrhythmia
* Indications * Ventricular Arrhythmia * SFx * Palpitations Chest pain CHF Edema Tremor Convulsions |
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Prochlorperazine
|
DA Receptor Inhibitor
(medullary) * Indications * Emesis |
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Dronabinol
|
Cannbinoid
* Indications * Emesis |
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Granisetron
|
5HT3 Antagonist
* Indications * Nausea from Chemotherapy |
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Megestrol
|
Progestational Agonist
* Indications * Appetite stimulation |
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Palivizumab
|
Anti-RSV fusion protein
* Indications * RSV Infection |
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Amlodipine
|
Ca Channel Blocker in smooth musc
* Indications * Angina Hypertension * SFx * dizziness palpitations |
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Felodipine
|
Ca Channel Inhibitor
* Indications * HTN * SFx * With Cyp3A4 (grapefruit juice) |
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Baclofen
|
GABA-B agonist
* Indications * Spasticity |
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Dantrolene
|
SR calcium release inhibitor
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Tizanidine
|
alpha 2 adrenergic agonist
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Riluzole
|
???
* Indications * Extend survival in ALS |
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Sibutramine
|
MAO inhibitor
? 5HT and NE reuptake * Indications * to reduce appetite |
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Megestrol
|
Progesterone derivative
|
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Metoclopramide
|
DA antagonist
* Indications * Emesis |
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Meperidine
|
Mu opioid agonist
? antimuscarinic effects * Indications * Gallstone pain (least likely of opioids to cause Oddi spasm) |
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Propoxyphene
|
Narcotic agent
? mild analgesic effects |
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