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186 Cards in this Set

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Trastuzumab
mAb inhibitor EGFR2 (Her2/neu)

** Indications:
1st line for met breast CA Her2/neu+

** SFx:
fever
pain
chills
Gefitinib
EGFR TK inhibitor

** Indications
3rd line met lung CA
Salvage therapy breast CA
EGFR
Erlotinib
EGFR TK inhibitor

*Indications
3rd line met lung CA
salvage for breast CA

*SFx
N/V/D
Skin rash
Weight loss
EGFR
Cetuximab
mAb inhibitor of EGFR

* Indications
3rd line lung CA
salvage for breast CA

* SFx
N/V/D
Weight loss
Skin rash
Daunorubucin
Doxorubicin
DNA Intercalators that inhibit Topo II

* Limiting toxicity:
Bone marrow failure
Cardiotoxicity
Anthracycline class
Methotrexate
Inhibitor of FH2 --> FH4 synthesis
(tetrahydrofolate for thymidine synthesis)

* Limiting toxicity:
Marrow failure
acute renal failure
CNS encephalopathy

*Resistance mech:
reduced uptake
reduced polyglutamylation
increased DHFR repeats
increased thymidylate synthetase
Antifolate agent
Vincristine
Vinblastine
Taxol
Tubulin-binding

* Limiting Toxicity:
Neuropathy
SIADH (VCR/VBL)

* Resistance:
Altered tubulin
Alkaloids
Cisplatin
Alkylating agent
(cx link, ss/ds break)

* Limiting toxicity:
Renal
ovulation and sperm
ATN
ototoxicity

* Resistance:
increased glutathione
increased metallothionein
Like cyclophosphamide.
Cyclophosphamide
Alkylating agent
(cx link, ds/ss breaks)

* Limiting Toxicity:
Renal
sperm and ovulation
hemorrhagic cystitis
bladder fibrosis
SIADH
Like cisplatin.
Bleomycin
Induction of ss/ds breaks

* Indications:
Cancer

* SFx
subacute pneumonitis

* Resistance:
Bleomycin hydroxylase
L-Asparaginase
Inhibits Asn --> Asp + NH3
(tumor specific)

* Indications:
Acute lymphoblastic lymphoma

* SFx
Hypersensitivity
Pancreatitis
Hepatotoxicity
5-Fluorouracil
(5FU)
Uracil analog

* Limiting toxicity:
marrow failure
Nucleotide analog
3'-azido-3'-deoxythymidine
Nucleotide analog

* Limiting tox:
marrow failure
Cytosine arabinoside
Nucleotide analog

* Limiting toxicity:
marrow failure
5-azacytidine
Nucleotide analog

* Limiting tox:
marrow failure
6-mercaptopurine
Purine analog

Limiting tox:
marrow failure
cholestatic jaundice
6-thioguanine
Purine analog

* Limiting toxicity:
marrow failure
Imatinib
BCR-Abl TK inhibitor
Also inhibits SCF, PDGF, c-kit

* Indications:
Philadelphia chromosome+ CML (9:22)
c-kit+ GI stromal tumor

* SFx
N/V/D
Edema
Cramps
Heartburn
Rituximab
mAb CD20 binding
induces ADCC

*Indications:
CD20+ refractory B cell non-Hodgkin's lymphoma

* SFx:
fever
chills
thrombocytopenia
neutropenia
anti-B cells
Bortezomib
26 S proteasome inhibitor

* Indications:
Multiple myeloma

* SFx:
fatigue
N/V/D
fever
thrmobocytopenia
BORat's (Evgeniy's) favorite
Bevacizumab
mAb VEGF inhibitor

* Indications:
1st line met colorectal CA
(with 5-FU)

* SFx:
Bowel perf & hemorrhage
impaired wound healing
Folkman.
NO
Induces guanylate cyclase
SM relaxation

* Indications
Neonatal RDS
Acute RDS

* SFx
vasodilation if given systemically
Benzodiazepines
Allosteric GABA-A
(c = 1/2-1/3 for Lo ~ 50k)

* SFx
Respiratory depression

* Reversal:
Flumazenil
Barbiturates
Allosteric GABA-A
(>> BZ)

* SFx
(worse) respiratory depression
Flumazenil
Competitive inhibor at BZ site on GABA-A

* Indications
reversal of BZ

* SFx
withdrawal in dependency
Alpha 1 Adrenergic

Actions
Vascular SM -- Contraction
Genitourinary SM -- Contraction
Heart -- Contractility
Liver -- Glycogenolysis

Intestinal SM -- Relaxation
Alpha 2 Adrenergic

Actions
Vascular SM -- Contraction

Platelets -- Aggregation
Nerve -- ↓NE
Pancreas -- ↓Insulin
Beta 1 Adrenergic

Actions
Heart:
↑Ionotropy
↑chronotropy
↑AV conduction

Renal:
↑Renin
Beta 2 Adrenergic

Actions
Liver --
↑Glycogenolysis
↑Gluconeogenesis

Skeletal Musc: ↑Glycogenolysis
Adipose tissue: ↑lipolysis

SM -- Relaxation
Isoproterenol
Nonselective Beta Agonist

* Indications:
Asthma

* SFx
Hypotension
Tachycardia
↑Chronotropy
Dobutamine
Beta 1 selective agonist

* Indications
Bridge therapy in end-CHF

* SFx
Increased arrhythmia risk
Propranolol
Nonselective Beta Blocker

* Indications
CHF
HTN
Glaucoma

* SFx
Asthma exacerbation
CNS sedation
↓Libido
Timolol
Nonselective Beta Blocker

* Indications
CHF
HTN
Glaucoma

* SFx
↓Libido
Asthma Exacerbation
CNS Sedation
Prazosin
Selective Alpha 1 Blocker

* Indications
HTN
CHF

* SFx
Postural hypotension
Syncope
Clonidine
Alpha 2 Agonist (CNS)
(Paradoxical! Recall ↓NE in nerves)

* Indications
Glaucoma
HTN

* SFx
Dry mouth
Sedation
Bradycardia
-Caine family local anesthetics
Ester Local Anesthetic (e.g. procaine)
Amide Local anesthetics (2 I's e.g. procainamide, lidocaine)


↑ efficacy IF:
Increased Lipophilic R groups
Charged quaternary amine

↑ penetration
Uncharged tertiary amine
Phenelzine
MAO Inhibitor

* Indications
Depression
Parkison's

* SFx
"Serotonin surge"
Restlessness
tremors
seizures
Tyramine
Uptake by VMAT to displace vesicular neurotransmitter
Imipramine
Inhibit NET
(NE and 5HT; ? DA)

* Indications
Depression

* SFx
Postural hypotension
Sinus tachycardia
** P450 **
Tricyclic Antidepressant
Desipramine
NET Inhibitor
(5HT and NE)

* Indications:
Depression

* SFx:
Anticholinergic (dry mouth, cardiac, somnolence)
Sedation
Tricyclic
Clomipramine
NET Inhibitor

* Indications:
Depression
TCA
Amitriptyline
NET inhibitor
(5HT and NE)

* Indications:
Depression

* SFx:
Anticholinergic: dry mouth, cardiac
Sedation
TCA
Cocaine
NET Inhibitor

* Indications
Local anesthetic
Vasoconstrictor
Methamphetamine
(1) Displacement of neurotransmitters like tyramine
(2) Inhibit MAO
(3) Direct alpha and beta agonists

* Indications:
Stimulant

* SFx
↑BP
Restlessness/Agitation
Dizziness/Tremor
Erectile dysfunction
Ephedrine
(1) Displacement of neurotransmitters (Tyramine)
(2) MAO Inhibitor
(3) alpha and beta agonist

* Indications:
Nasal decongestant
Anti-appetite
Amphetamine
Methylphenidate
(1) Displacement like tyramine
(2) MAO Inhibitor
(3) alpha and beta agonist

* Indications
ADHD

* SFx
HTN
Restlessness/Agitation
Dizziness/Tremor
Erectile dysfunction
Amphetamine
Reserpine

(dose dependent)
*Irreversible* VMAT Inhibitor (DA, NE, 5HT)

Low dose: degradation by MAO
High dose: overwhelm MAO

* Indications:
HTN (low dose)
Psychosis (high dose)

* SFx
Transient sympathetic
psychotic depression
Pancuronium
nAChR antagonist

* Indications
Nondepolarizing paralytic

* Reversal:
AChE Inhibitors
Like tubocurare
Tubocurare
nAChR antagonist

* Indications:
Nondepolarizing paralytic

* Reversal:
AChE Inhibitors
Scopolamine
mAChR antagonist

* Indications
Anti-emesis

* SFx
Altered mental status
Remember the Vomit Comet?
Atropine
mAChR antagonist

* Indications:
Pupil dilation
Reverse organophosphates
Reverse sinus-bradycardia
Dry mouth
Inhibit vagal reflexes
Remember The Rock?
Succinylcholine
nAChR agonist

* Indications
Depolarizing paralytic
Sux.
Pilocarpine
mAChR agonist

* Indications
Glaucoma (Miotic)
Xerostomia (↑saliva)
Carbachol
mAChR agonist

* Indications
Glaucoma (mitotic agent)
CarbaCHOL(ine)
Methacholine
mAChR agonist

* Indications
Vasodilation
Vagomimetic
"Diagnosis of Asthma"
*M*etha *Choline*
Neostigmine
AChE Inhibitor

* Indications
Glaucoma
Myasthenia gravis
Eaton-Lambert Syndrome (like MG against Ca channels)
Abd distension
Pancuronium reversal.
Botunlinum Toxin
AB inhibitor of synaptobrevin
(vesicle fusion)

* Indications
Flaccid paralyzing agent
Wrinkle relaxation
Tolcapone
COMT Inhibitor
(L-DOPA --COMT--> 3-O-MD)

* Indications
Parkinson's Dz

* SFx
Fulminant hepatic failure
CNS + Peripheral effects
Like Entacapone
Entacapone
COMT Inhibitor
(L-DOPA --COMT--> 3-O-MD)

* Indications:
Parkinson's Dz

More peripheral than Tolcapone
Like Tolcapone
Chlorpromazine
(Thorazine)
D1-D5 Receptor Inhibitor

* Indications
Psychosis
Nausea

* SFx
Parkinsonism
Tardive dyskinesia

Extrapyramidal: 1+
Sedation: 3+
Thioridizine
(Mellaril)
D1-D5 Receptor Inhibitor

* Indications:
Psychosis

* SFx
Tardive dyskinesia
Parkinsonism

Extrapyramidal: 1+
Sedation: 3+
Most similar to thorazine.
Thiothixine
(Navare)
D1-D5 receptor antagonist

* Indications:
Psychosis

* SFx
Tardive dyskinesia
Parkinsonism

Extrapyramidal: 2+
Sedation: 2+
Haloperidol
(Haldol)
D1-D5 Receptor Antagonist

* Indications
Psychosis

* SFx
Tardive dyskinesia
Parkinsonism

Extrapyramidal signs: 3+
Sedation: 1+
Best associated with TD
Clozapine
Most selective D4 antagonist

* Indications
Psychosis

* SFx
"many"
Neutropenia (agranulocytosis)
Atypical antipsychotics
Risperidone
Less selective D4 Antagonist

* Indications:
Psychosis

* SFx
Neuroleptic malignant syndrome
Tardive dyskinesia
Weight gain
Atypical Antipsychotic
Olanzepine
5HT2 and D2 antagonist

* Indications
Psychosis
Mania

* SFx
Tardive dyskinesia
Extrapyramidal effects
Weight gain
Neuroleptic malignant syndrome
**P450 Metabolism**
Phenytoin/Fosphenytoin
? Na Channel Inhibitor

* Indications
Epilepsy
Mania

* Acute SFx
Nystagmus
Ataxia
Diplopia
Sedation

* Chronic SFx
Hirsutism
Gingivial hyperplasia
peripheral neuropathy

** TERATOGEN **
** 0-order kinetics **
Valproic Acid
Valproate
?

* Indications
Epilepsy
Mania

* SFx
Tremor
Weight gain
Nausea

** TERATOGEN **
Carbamazepine
? Na Channel Inhibitor

* Indications
Epilepsy
Mania

* SFx
Ataxia
Diplopia
Sedation
** Aplastic anemia

** TERATOGEN **
Like phenytoin
Salicylates
Mixed Cox-1 Cox-2 Inhibitor

* Indications
Analgesia (E2)
Inflammation (I2, E2)
Pyrexia (E2 in thalamus)
Thrombosis (TxA2)

* SFx
CNS: h/a, confusion, tinnitus
Hepatic: LFTs, Reye's, hepatitis
Nephro: Creat, nephrotic
Heme: rare dyscrasias
Indomethacin
Mixed Cox-1 Cox-2 Inhibitor

* Indications
Pyrexia (E2)
Analgesia (E2)
Inflammation (I2, E2)
Thrombosis (TxA2)

* SFx:
CNS: tinnitus, confusion, H/A
Hepatic: Reye's, hepatitis
Neprho: ↑Creat, Nephrotic
Heme: Dyscrasia (rare)
Ketorolac
Both Cox-1 and Cox-2 Inhibition

* Indications
Inflammation (E2, I2)
Pyrexia (E2)
Analgesia (E2)
Thrombosis (TxA2)

* SFx
CNS: HA, confusion, tinnitus
Hepatic: Reye's, hepatitis
Nephr: ↑Creat, nephrotic
Heme: rare dyscrasias
-Coxibs

(Rofecoxib, Valdecoxib, Celecoxib)
Selective Cox-2 Inhibitor

* Indications
Inflammation (E2, I2)
Analgesia (E2)

* SFx
increased thrombosis due to unopposed I2 inhibition
Carbidopa
DOPA decarboxylase inhibitor

* Indications
Parkinson's Dz with L-DOPA



Uptake Dependent on GI Acid and Amino Acid intake
D1 vs. D2 in Parkinson's Dz
Final Common:
Inhibit GPi which inhibits thalamus (net increase in thalamus)

D1:
activation of striatum which inhibits GPi

D2 inhibition of striatum which inhibits GPe which inhibits STN which activates GPi. Wow.
Bromocriptine
D1-D5 Agonist

* Indications
Prolactinoma

* SFx
NVD
Hypotension
Psychosis

Dyscrasias
Like Pergolide
Pergolide
D1-D5 Agonist

* Indications
Parkinson's Dz
Prolactinoma

* SFx
NVD
Hypotension
Dyskinesias
Psychosis/Sedation
Like bromocriptine
Trazodone
NET Inhibitor
(NE and 5HT)

* Indications:
Depression

* SFx
Anticholinergic: dry mouth, cardiac
Sedation
Priapism =)
TCA
Fluoxetine
SSRI

* Indications:
Depression

* SFx
Tremor
? Suicide
Contraindicated with MAO
Like Paroxetine, sertraline, citalopram.
Sertraline
SSRI

* Indications:
Depression

* SFx
? Suicide
Tremor

Contraindicated with MAO
Like Paroxetine, fluoxetine, citalopram
Citalopram
SSRI

* Indications:
Anxiety
Depression

* SFx
? Suicide
Tremor
Contraindicated with MAO
Like paroxetine, fluoxetine, sertraline
Paroxetine
SSRI

* Indications
Depression
Anxiety

* SFx:
Tremor
? Suicide
Contraindicated with MAO
Like fluoxetine, sertraline, citalopram
Bupropion
NE and DA reuptake inhibitor

* Indications *
Depression
Tobacco addiction

* SFx *
Seizures
Hallucinations
Atypical Antidepressant
DA and NE synthesis
Tyr --tyrosine hydroxylase -->
L-DOPA --DOPA carboxylase-->
DA --DA beta hydroxylase-->
NE
Serotonin (5HT) Synthesis
Tryptophan --TP hydroxylase-->
5-OH-TP --DOPA carboxylase-->
Serotonin (5HT)
Class Ia Antiarrhythmic
Na block with some K+ block

Quinidine
Procainamide
Class Ib Antiarrhythmic
Derease repolarization time

Lidocaine
Class Ic antiarrhythmic
Purest Na block

Encainamide
Class II Antiarrhythmic
Beta blockers

Propranolol
Atenolol
Class III Antiarrhythmic
K+ blocker

Amiodarone
Class IV Antiarrhythmic
Ca2+ Blocker

Verapamil
Diltiazem
Digitalis
Na/K ATPase inhibitor
(effect to increase Ca)

Decreases conduction through AV node
Glucocorticoids

Immunomodulatory effects
T lymphocyte depletion

Monocytopenia

Eosinopenia

↑Neutrophils
Glucocorticoids Findings

Endocrine, Ophtho, GI, Psych, Derm
Endocrine: ↑glucose, ↑obesity, hirsutism

Psych: Mood and Psychosis

Ophtho: cataracts and glaucoma

GI: pancreatitis

Derm: Fragile skin
Cushing's
Glucorticoids in order of potency and duration
Cortisol 1X
Prednisone 4X
Methylpredinisone 5X
Dexamethasone 30X
Etanercept
Soluble TNFR

* Indications *
RA
Psoriatic arthritis
Ankylosing spondylitis
Psoriasis

* SFx *
Opportunistics (TB, aspergillus, PCP, Listeria)
Lupus-like syndrome
Aplastic anemia (rare)
Infliximab
mAb TNF binding

* Indications *
RA along with methotrexate
Crohn's Dz
Ankylosing spondylitis

* SFx *
Opportunistic Infections (aspergillus, PCP, Listeria, TB)
Lupus-like effects
Aplastic anemia (rare)
Adalimumab
mAb binding TNF

* Indications *
RA with MTX
Ankylosing spondylitis
Crohn's Dz

* SFx *
Opportunistic Infections (aspergillus, TB, PCP, Listeria)
Aplastic anemia (rare)
Lupus-like syndrome
Like infliximab
Anakinra
Recombinant IL-1r

* Indications *
RA
Only one available in many ways
Cyclosporine
Binds immunophilin to inhibit Calcineurin

* SFx *
Nephrotoxicity (requires mannitol diuresis)
Neurotoxicity
Neoplasms (??!)
HTN
↑K+
Hirsutism
Hyperglycemia
Hyperlipidemia
Almost like tacrolimus
Tacrolimus
FK506 binding inhibitor of cacineurin
10-100 x more powerful than cyclosporine
Azathiopurine
6 Mercaptopurine not substrat for ADA --> acumulation of purines in lymphocytes
rememeber ADA- SCID
Mycophenolate mofetil
mycophenolic acid ihibits inosine monophosphate dehydrogenase

(required for guanine synthesis)
Leflunomide
Inhibito of dihydro-oroate dehydrogenase

(required for pyrimidine synthesis)
Anti-Lymphocyte Globulin
Anti-Thymocyte Globulin
Polyclonal Ab against TCR/CD3

* SFx *
Anaphylaxis
Serum sickness
Glomerulonephritis
OKT3
Murine mAb against TCR/CD3

* SFx *
Fever
Myalgia
Arthralgia
GI Irritation
Sirolimus
Inhibits mTOR, required for IL2-dependent G1 --> S transition

Also a macrolide antibiotic

* SFx *
hyperlipidemia
HTN
Hypokalemia
Pancytopenia
aka Rapamycin
Daclizumab
murine mAb against CD25
Basilizimab
Chimeric murine/human mAb against CD25
Like Daclizumab
Vesamicol
Inhibits H+/ACh antiport
(Vesicle accumulation)
Omeprazole
Irreversible H/K ATPase inhibitor
(by S-S requires 2 per ATPase)

* Indications *
Zollinger-Ellison
GERD
Ulcers

* SFx *
Elevated infection risk
Bezoars

** P450 Inhibitor **
Pyrilamine
H1 Antagonist
mAChR Antagonist

* Indications *
Inflammation (H1)
Emesis (mAChR)
Runny nose (mAChR)
Sedation (mAChR)
Cough (mAChR)

* SFx *
Sedation
Dry mouth
Long QTc

** P450 Inhibitor **
Chlorpheniramine
H1 Antagonist
mAChR antagonist

* Indications *
Inflammation (H1)
Emesis (mAChR)
Cough (mAChR)
Sedation (mAChR)
Runny nose (mAChR)

* SFx *
Sedation
Dry Mouth
Blurred vision
Long QTc

** P450 Inhibitor **
Meclizine
H1 Antagonist
mAChR Antagonist

* Indications *
Inflammation (H1)
Cough (mAChR)
Emesis (mAChR)
Runny nose (mAChR)
Sedation (mAChR)

* SFx *
Sedation
Dry mouth
Blurry vision
Long QTc

** P450 Inhibitor **
Cyclizine
H1 Antagonist
mAChR Antagonist

* Indications *
Inflammation (H1)
Cough (mAChR)
Runny nose (mAChR)
Sedation (mAChR)
Emesis (mAChR) (Especially)

* SFx *
Sedation
Blurry Vision
Dry mouth
Long QTc

** P450 Inhibitor **
Like meclizine
Phenergan
H1 Antagonist
mAChR Antagonist

Fewer CNS fx due to ↓DA activity

* Indications *
Emesis (mAChR) (Especially)
Cough (mAChR)
Runny nose (mAChR)
Inflammation (H1)

* SFx *
Dry Mouth
Long QTc

** P450 Inhibitor **
Fenofexidine
Selective H1 Antagonist

* Indications *
Inflammation (Allergies)

Note: active metabolite of terfenidine without QTc issues
Allegra
Loratidine
Selective H1 Antagonist

* Indications *
Inflammation (Allergies)

* Note: *
No QTc issues
few CNS issues
Cimetidine
H2 Antagonist

* Indications *
GERD
Ulcers (gastric and duodenal)
zollinger-ellison

* SFx *
Bezoars
Infection
CNS depression

** P450 Inhibitor **
Like ranitidine and famotidine
Ranitidine
H2 Antagonist

* Indications *
GERD
Duodenal and Gastric ulcers
Zollinger-Ellison

* SFx *
Bezoars
Infection

** P450 Inhibitor **
Like cimetidine and famotidine
Famotidine
H2 Antagonist

* Indications *
GERD
Zollinger-Ellison
Gastric and Duodenal Ulcers

* SFx *
Bezoars
Increased infection risk

** P450 Inhibitor **
Gemfibrozil
Fibrate PPARalpha Agonist
(↑Hormone Sensitive Lipase, Catabolism of VLDL, ↓LDL production, ↓FFA)

* Indications *
Hyperlipidemia inc. TG
Dysbetalipoproteinemia

* SFx *
GI Distress
Cholelithiasis
Myositis
Albumin Interaction
GemFIBROzil
Fenofibrate
Fibrate PPARalpha Agonist
(↓LDL, ↓FFA, ↑VLDL catabolism, ↑hormone sensitive lipase)

* Indications *
Hyperlipidemia (TG)
Hypercholesterolemia
Dysbetalipoproteinemia

* SFx *
GI Distress
Myositis
Cholelithiasis
Albumin interaction
FenoFIBRATE
Niacin
Inhibits hormone sensitive lipase
(↓FFA, ↓LDL, ↓TG, ↓Lp(a), ↑HDL)

* Indications *
Hyperlipidemia
Hypercholesterolemia

* SFx *
Pruritis
H/A
Flushing
Hyperglycemia **
Gout
GI Bleeding
Liver problems
Sitostamol-Ester
?? Cholesterol Absorption Inhibitors

* Indications *
Hypercholesterolemia

* SFx *
none?
Colesevelam
? Cholesterol Absorption Inhibitor

* Indications *
Hypercholesterolemia

* SFx *
none?
Ezetimibe
? Cholesterol Absorption Inhibitor

* Indications *
Hypercholesterolemia

* SFx *
none?
Cholestyramine
Anion-exchange Bile Acid Binding Resin

* Indications *
Hypercholesterolemia

* SFx *
Bloating
Constipation
Abdominal Discomfort
Decreased absorption of lipid drugs
Colestipol
Anion-exchange Bile Acid Binding Resin

* Indications *
Hypercholesterolemia

* SFx *
Adominal Discomfort
Decreased drug absorption
Constipation
Bloating
Statins
HMG CoA Reductase Inhibitors

* Indications *
Hyperlipidemia

* SFx *
Toxicity with Triazole antifungal agents
Rare rhabdomyolysis
Hydrochlorothiazide
Inhibits Na and Cl uptake in the distal tubule

* Indications *
HTN
Calcium reuptake
Neprhogenic DI (good to lose salt and induce RAA system, and DCT drugs do not affect main CD gradient)

* SFx *
Hypokalemia
Captopril
ACE Inhibitor

* ACE Roles *
AT-I --> AT-II and reduced bradykinin

* Indications *
HTN

* SFx *
5-10% Dry Cough (use -sartan ARB)
Enalapril
ACE Inhibitor

ACE Roles:
(ATI --> ATII, and decreases bradykinin)

* Indications *
HTN

* SFx *
5-10% cough
Lisinopril
ACE Inhibitor

* ACE Roles *
ATI --> ATII
decreases bradykinin

* Indications *
HTN

* SFx *
5-10% Cough (use -sartan ARB)
-Sartans

Losartan
Valsartan
Irbesartan
etc.
Angiotensin II Receptor Blocker

(no bradykinin effect)

* Indications *
HTN

* SFx *
Hyperkalemia
Spironolactone
Inhibitor of Na/K ATPase
(K+ sparing)

* Indications *
K+ sparing diuresis
Furosemide
Inhibitor of Na/K/2Cl coport

* Indications *
HTN

* SFx *
Hypokalemia
Hypocalcemia
Metaproterenol
B2 Selective Agonist

* Indications *
Asthma
Like Albuterol
Albuterol
B2 Selective Agonist

* Indications *
Asthma
Like... albuterol.
Salmeterol
B2 Selective Agonist
Long-acting

* Indications *
Asthma
Flutamide
Androgen receptor inhibitor

* Indications *
Prostate CA
Sorafenib
"Multikinase inhibitor"
(Tyr and Ser/Thr)

* Indications *
Renal Cell CA
-nib
Leuprolide
GnRH Analogue

* Indications *
Adv. Prostate CA **
Breast CA
Endometriosis
Fibroids
Precocious puberty
IVF ovarian stimulation
Fentanyl
Opiod
Naloxone
Mu opiod antagonist
Naldolol
Nonspecific Beta Blocker
(long half life)
Labetalol
Alpha 1, Beta blocker

* Indications *
Pheochromocytoma
(recall danger of unbalanced beta block)
Alprostadil
Prostaglandin E1
(vasodilator)

* Indications *
Erectile dysfunction
Epoprostenol
Prostaglandin I2
(Vasodilator)

* Indications *
Pulmonary HTN
Latanoprost
Prostaglandin F2a

* Indications *
Glaucoma (aq humor outflow)
Misoprostol
Prostaglandin E1

* Indications *
NSAID gastric and duodenal ulcers
Dinoprostone
Prostaglandin E2

* Indications *
Cervical dilation
Uterine contraction
Ticlopidinie
ADP/platelet binding inhibitor

* Indications *
Antithrombosis (synergistic with aspirin)
Like clopidrogrel
Clopidogrel
ADP/thrombocyte binding inhibitor

* Indications *
Antithrombosis (synergistic with salicylates)
Like ticlopidine
Alteplase
Plasminogen activator

* Indications *
Thrombolysis
Eptidfibatide
GP IIb/IIIa inhibitor

* Indications *
Antithrombosis
Indapamide
Thiazide diuretic

* SFx *
Hyperuricemia
Minoxidil
? K+ Channel Antagonist
? nitrate

* Indications *
HTN
Hair loss
Rogaine
Alosetron
5-HT3 antagonist

* Indications *
"Diarrhea" irritable bowel syndrome
Domperidone
D2 Receptor Antagonist

* Indications *
"Prokinetic Agent"
? Parkinson's Dz
Dronabinol
Cannabinoid

* Indications *
Nausea control in chemotherapy
Lansoprazole
Proton pump inhibitor
Phentermine
Amphetamine derivative

* Indications *
Appetite control
Phen-Fen
Sulfasalazine
Sulfa + Salicylate

* Indications *
Ulcerative Colitis
Ursodiol
Cholesterol Dissolving Agent

* Indications *
Cholesterol Gallstones
Propylthiouracil
Thyroid Peroxidase Inhibitor

* Indications *
Hyperthyroidism
Procainamide
Class IA Antiarrhythmic

* Indications *
Ventricular arrhythmia

* SFx *
Lupus-like syndrome **
Agranulocytosis
Bone marrow depression
Disopyramide
Class IA Antiarrhythmic

* Indications *
Ventricular arrhythmia

* SFx *
Atrial tachyarrhythmia
Heart block
Conduction abnormalities
Flecainide
Class IC Antiarrhythmia

* Indications *
Ventricular Arrhythmia
(life-threatening)
* SFx *
Paresthesias
Ataxia
Flushing
Vertigo
Tinnitus
Depression
Mexiletine
Class Ib Antiarrhythmia

* Indications *
Ventricular Arrhythmia

* SFx *
Palpitations
Chest pain
CHF
Edema
Tremor
Convulsions
Prochlorperazine
DA Receptor Inhibitor
(medullary)

* Indications *
Emesis
Dronabinol
Cannbinoid

* Indications *
Emesis
Granisetron
5HT3 Antagonist

* Indications *
Nausea from Chemotherapy
Megestrol
Progestational Agonist

* Indications *
Appetite stimulation
Palivizumab
Anti-RSV fusion protein

* Indications *
RSV Infection
Amlodipine
Ca Channel Blocker in smooth musc

* Indications *
Angina
Hypertension

* SFx *
dizziness
palpitations
Felodipine
Ca Channel Inhibitor

* Indications *
HTN

* SFx *
With Cyp3A4 (grapefruit juice)
Baclofen
GABA-B agonist

* Indications *
Spasticity
Dantrolene
SR calcium release inhibitor
Tizanidine
alpha 2 adrenergic agonist
Riluzole
???

* Indications *
Extend survival in ALS
Sibutramine
MAO inhibitor
? 5HT and NE reuptake

* Indications *
to reduce appetite
Megestrol
Progesterone derivative
Metoclopramide
DA antagonist

* Indications *
Emesis
Meperidine
Mu opioid agonist
? antimuscarinic effects

* Indications *
Gallstone pain
(least likely of opioids to cause Oddi spasm)
Propoxyphene
Narcotic agent
? mild analgesic effects