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474 Cards in this Set

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Drugs ending with:
-ane
Inhalational general anesthetic
Ex-Halothane
Drugs ending with:
-azepam
Benzodiazepine
Ex-Diazepam
Drugs ending with:
-azine
Phenothiazine(neuroleptic, antiemetic)
Ex-Chlorpromazine
Drugs ending with:
-azole
Antifungal
Ex-Ketoconazole
Drugs ending with:
-barbital
Barbiturate
Ex-Phenobarbital
Drugs ending with:
-caine
Local anesthetic
Ex-Lidocaine
Drugs ending with:
-cillin
Penicillin drug
Ex-Methicillin
Drugs ending with:
-cycline
Antibiotic (protein synthesis inhibitor)
Ex-Tetracycline
Drugs ending with:
-ipramine
Tricyclic antidepressant
Ex-Imipramine
Drugs ending with:
-navir
Protease inhibitor
Ex-Saquinavir
Drugs ending with:
-olol
Beta-blocker
Ex-Propanolol
Drugs ending with:
-operidol
Butyrophenone (neuroleptic)
Ex-Haloperidol
Drugs ending with:
-oxin
Cardiac glycoside(+ inotrope)
Ex-Digoxin
Drugs ending with:
-phylline
Methylxanthine
Ex-Theophylline
Drugs ending with:
-pril
ACE inhibitor
Ex-Captopril
Drugs ending with:
-terol
Beta-2 agonist
Ex-Albuterol
Drugs ending with:
-tidine
H2 antagonist
Ex-Cimetidine
Drugs ending with:
-triptyline
Tricyclic antidepressant
Ex-Amitriptyline
Drugs ending with:
-tropin
Pituitary hormone
Ex-Somatotropin
Drugs ending with:
-zosin
alpha-1 antagonist
Ex-Prazosin
What drug causes:
Atropine like side effects
Tricyclics
What drug causes:
Cardiac toxicity
Doxorubicin(Adriamycin), Daunorubicin
What drug causes:
Coronary vasospasm
Cocaine
What drug causes:
Cutaneous flushing
Niacin, Calcium channel blockers, adenosine, vancomycin
What drug causes:
Torsades des pointes
Class Ia(quinidine) & Class III(Sotalolo) antiarrhythmics; cisapride
What drug causes:
Agranulocytosis
Clozapine, Carbamazepine, Colchicine
What drug causes:
Aplastic anemia
Chloramphenicol, Benzene, NSAID's
What drug causes:
Grey baby syndrome
Chloramphenicol- transferred through the placenta
What drug causes:
Hemolysis in G6PD-deficient pts
Sulfonamides, Isoniazid(INH), aspirin, ibuprofen, primaquine, nitrofurantoin
What drug causes:
Thrombotic complications
OCP's
What drug causes:
Coughing
ACE Inhibitors
What drug causes:
Pulmonary fibrosis
Bleomycin, amiodarone, busulfan
What drug causes:
Acute cholestatic hepatitis
Macrolides
What drug causes:
Focal to massie hepatic necrosis
Halothane, Valproic acid, acetaminophen, Amanita phalloides
What drug causes:
Hepatitis
Isoniazid (INH)
What drug causes:
Pseudomembranous colitis
Clindamycin, ampicillin
What drug causes:
Adrenocortical insufficiency
Glucocorticoid withdrawl
What drug causes:
Gynecomastia
"Some Drugs Create Awesome Knockers"
Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, Estrogens, Ketoconazole
What drug causes:
Hot flashes
Tamoxifen
What drug causes:
Gingival Hyperplasia
Phenytoin
What drug causes:
Osteoporosis
Corticosteroids, Heparin
What drug causes:
Photosensitivity
"SAT for a photo"
Sulfonamides, Amiodarone, Tetracycline
What drug causes:
SLE-like syndrome
"HIPP"
Hydralazine, Isoniazid(INH), Procainamide, Phenytoin
What drug causes:
Tendonitis, tendon rupture & cartilage damage in kids
Fluoroquinolones
What drug causes:
Fanconi's Syndrome
Expired tetracycline
Fanconi's syndrome- Multiple defects of tubular function
What drug causes:
Interstitial nephritis
Methicillin
What drug causes:
Hemorrhagic Cystitis
Cyclophosphamide, Ifosfamide
What drug causes:
Cinchonism
Quinidine, Quinine
Cinchonism- tinnitus, headache, deafness & occasionally anaphylactoid shock
What drug causes:
Diabetes insipidus
Lithium, Demeclocycline
What drug causes:
Seizures
Bupropion, Imipenem/Cilastatin
What drug causes:
Tardive dyskinesia
Antipsychotics(more likely w/ typical antipsychotics)
Tardive dyskinesia- involuntary movements of the facial muscles & tongue
What drug causes:
Disulfiram-like reaction
Metronidazole, Certain cephalosporins, Procarbazine, Sulfonylureas
Disulfiram-like reactions- Increased drinking hangovers
What drug causes:
Nephrotoxicity/Neurotoxicity
Polymyxins
What drug causes:
Nephrotoxicity/Ototoxicity
Aminoglycosides, Loop diuretics, Cisplatin
P450 inducers
"Queen Barb takes Phen-phen and Refuses Greasy Carbs"
Quinidine, Barbiturates, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, St. Johns Wart
P450 inhibitors
"Inhibitors stop Cyber-Kids from Eating Grapefruit"
Isoniazid, Sulfonamides, Cimetidine, Ketoconazole, Erythromycin, Grapefruit juice
P450 Inducer or Inhibitor:
Quinidine
P450 Inducer
P450 Inducer or Inhibitor:
Barbiturates
P450 Inducer
P450 Inducer or Inhibitor:
Phenytoin
P450 Inducer
P450 Inducer or Inhibitor:
Rifampin
P450 Inducer
P450 Inducer or Inhibitor:
Griseofulvin
P450 Inducer
P450 Inducer or Inhibitor:
Carbamazepine
P450 Inducer
P450 Inducer or Inhibitor:
St. John's Wart
P450 Inducer
P450 Inducer or Inhibitor:
Isoniazid
P450 Inhibitor
P450 Inducer or Inhibitor:
Sulfonamides
P450 Inhibitor
P450 Inducer or Inhibitor:
Cimetidine
P450 Inhibitor
P450 Inducer or Inhibitor:
Ketoconazole
P450 Inhibitor
P450 Inducer or Inhibitor:
Erythromycin
P450 Inhibitor
P450 Inducer or Inhibitor:
Grapefruit Juice
P450 Inhibitor
Drugs with what qualities have the highest volume of distribution?
Fat soluble & basic drugs
Type of drug?
Prazosin
alpha-1 selective antagonist
Type of drug?
Terazosin
alpha-1 selective antagonist
Type of drug?
Doxazosin
alpha-1 selective antagonist
Type of drug?
Phenoxybenzamine
alpha non-selective antagonist
Type of drug?
Phentolamine
alpha non-selective antagonist
Type of drug?
Clonidine
Central alpha-2 agonist
Type of drug?
Guanbenz
Central alpha-2 agonist
Type of drug?
Guanfacine
Central alpha-2 agonist
Type of drug?
Methyldopa
Central alpha-2 agonist
Type of drug?
Trimethaphan
Ganglionic blocker
Type of drug?
Reserpine
Postganglionic sympathetic neuron blocker;
Inhibits uptake of dopamine into vesicles for conversion to NE
Type of drug?
Guanethidine
Postganglionic sympathetic neuron blocker;
Inhibits release of NE into synapse
Type of drug?
Hydralazine
Vasodilator
Antihypertensive drug that can cause a (+) coombs test & hemolysis
Methyldopa
Type of drug?
Nitroprusside
Vasodilator
Metabolized into CN
Type of drug?
Minoxidil
Vasodilator
Inhibits phosphodieseterase
Type of drug?
Verapamil
Calcium channel blocker
Class IV AA & vasodilator
Type of drug?
Diltiazem
Calcium channel blocker
Class IV AA & vasodilator
Type of drug?
Nifedipine
Calcium channel blocker
Vasodilator only (no AA activity like the other calcium channel blockers)
Type of drug?
Nitroglycerin
Antianginal drug- Nitrates
Metabolized into NO
Type of drug?
Isosorbide dinitrate
Antianginal drug- Nitrates
Metabolized into NO
Type of drug?
Digoxin
Cardiac glycoside for heart failure
Blocks Na/K pump which increases Na/Ca pump leading to increased Ca & therefore contractility
Type of drug?
Quinidine
Class Ia antiarrhythmic
Na channel blocker
Type of drug?
Procainamide
Class Ia antiarrhythmic
Na channel blocker
Type of drug?
Disopyramide
Class Ia antiarrhythmic
Na channel blocker
Type of drug?
Lidocaine
Class Ib antiarrhythmic
Na channel blocker
Type of drug?
Mexiletine
Class Ib antiarrhythmic
Na channel blocker
Type of drug?
Tocainide
Class Ib antiarrhythmic
Na channel blocker
Type of drug?
Flecainide
Class Ic antiarrhythmic
Na channel blocker
Type of drug?
Encainide
Class Ic antiarrhythmic
Na channel blocker
Type of drug?
Propafenone
Class Ic antiarrhythmic
Na channel blocker
Type of drug?
Sotalol
Class III antiarrhythmic
Potassium channel blocker
Type of drug?
Bretylium
Class III antiarrhythmic
Potassium channel blocker
Type of drug?
Amiodarone
Class III antiarrhythmic
Potassium channel blocker
EKG effect of Class Ia antiarrhythmic?
Widened QRS; increased QT
EKG effect of Class Ib antiarrhythmic?
None of the main ones
EKG effect of Class Ic antiarrhythmic?
Widened QRS; Increased PR & QT
EKG effect of Class II antiarrhythmic?
Increased PR
EKG effect of Class III antiarrhythmic?
Increased PR & QT
EKG effect of Class IV antiarrhythmic?
Increased PR
Type of drug?
Ticlopidine
Antiplatelet drug
Interferes w/ ADP-induced binding of fibrinogen to platelets
Type of drug?
Clopidogrel
Antiplatelet drug
Interferes w/ ADP-induced binding of fibrinogen to platelets
Type of drug?
Abciximab
Antiplatelet drug- Fiban drug
Monoclonal Ab that inhibits fibrinogen binding to GpIIb/IIIa
Type of drug?
Tirofibin
Antiplatelet drug- Fiban drug
Monoclonal Ab that inhibits fibrinogen binding to GpIIb/IIIa
Type of drug?
Streptokinase
Fibrinolytic- Systemic agent
Type of drug?
Urokinase
Fibrinolytic- Systemic agent
Type of drug?
Alteplase
Fibrinolytic- Tissue agent
Type of drug?
Reteplase
Fibrinolytic- Tissue agent
Type of drug?
Albuterol
Beta-2 agonist- asthma drug
Type of drug?
Metaproterenol
Beta-2 agonist- asthma drug
Type of drug?
Terbutaline
Beta-2 agonist- asthma drug
Type of drug?
Theophlline
Methylxanthine- asthma drug
Type of drug?
Aminophylline
Methylxanthine- asthma drug
Type of drug?
Ipratropium
Muscarinic antagonist- asthma drug
Type of drug?
Tiotropium
Muscarinic antagonist- asthma drug
Type of drug?
Fluticasone
Anti-inflammatory corticosteroids- asthma drug
Type of drug?
Cromolyn
Anti-inflammatory mast cell stabilizer- asthma drug
Type of drug?
Nedocromil
Anti-inflammatory mast cell stabilizer- asthma drug
Type of drug?
Zileuton
Anti-inflammatory leukotriene synthesis inhibitor- asthma drug
Type of drug?
Zafirlukast
Anti-inflammatory leukotriene receptor antagonist- asthma drug
Type of drug?
Montelukast
Anti-inflammatory leukotriene receptor antagonist- asthma drug
Type of drug?
Omalizunab
Anti-inflammatory Anti-IgE
Blocks IgE attachment to mast cells & basophils
Type of drug?
Thioridazine
Antipsychotic- Phenothiazine
Most cardiotoxic neuroleptic
Type of drug?
Fluphenazine
Antipsychotic- Phenothiazine
Most cardiotoxic neuroleptic
Type of drug?
Chlorpromazine
Antipsychotic- Phenothiazine
Most cardiotoxic neuroleptic
Type of drug?
Olanzapine
Atypical Antipsychotic
Type of drug?
Risperidone
Atypical Antipsychotic
Type of drug?
Fluoxetine
SSRI
Type of drug?
Paroxetine
SSRI
Type of drug?
Citalopram
SSRI
Type of drug?
Imipramine
Tricyclic antidepressant
Type of drug?
Desipramine
Tricyclic antidepressant
Type of drug?
Nortriptyline
Tricyclic antidepressant
Type of drug?
Clomipramine
Tricyclic antidepressant
Type of drug?
Doxepin
Tricyclic antidepressant
Type of drug?
Trancypromine
MAOI
Type of drug?
Haloperidol
Antipsychotic
Type of drug?
Clozapine
Atypical antipsychotic
Type of drug?
Sertraline
SSRI
What 2 drugs can be used in obsessive compulsive disorder
Olanzapine (atypical antipsychotic) & Clomipramine (TCA)
What TCA can also be used to treat bed wetting?
Imipramine
What is the least sedating TCA?
Desipramine
Which TCA has the least anticholinergic SE's?
Nortriptyline
Drug of choice in elderly to avoid confusion & hallucinations
What drugs cause neuroleptic malignant syndrome?
Haloperidol, Phenothiazines (e.g. thoridazine), & thiothixene
Type of drug?
Lithium
Mood stabilizer
5HT-1a agonist
Type of drug?
Phenelzine
MAOI
Type of drug?
Selegiline
MAOI (selective for MAO-B)
What drug causes increased frequency of GABA channel opening?
Benzodiazepines
What drug causes prolonged duration of GABA channel opening?
Barbiturates
Type of drug?
Oxazepam
Benzodiazepine
Short acting (3-8 hrs)
Type of drug?
Lorazepam
Benzodiazepine
Intermediate acting (12-24 hrs)
Type of drug?
Alprazolam
Benzodiazepine
Intermediate acting (12-24 hrs)
Type of drug?
Chlorazepate
Benzodiazepine
Long acting (1-3 days)
Type of drug?
Chlordiazepoxide
Benzodiazepine
Long acting (1-3 days)
Type of drug?
Diazepam
Benzodiazepine
Long acting (1-3 days)
Type of drug?
Flurazepam
Benzodiazepine
Long acting (1-3 days)
Type of drug?
Thiopental
Barbiturate
Ultrashort acting
Type of drug?
Pentobarbital
Barbiturate
Short acting
Type of drug?
Secobarbital
Barbiturate
Short acting
Type of drug?
Amobarbital
Barbiturate
Intermediate acting
Type of drug?
Butalbital
Barbiturate
Intermediate acting
Type of drug?
Phenobarbital
Barbiturate
Long acting
Type of drug?
Heroin
Opioid
Type of drug?
Morphine
Opioid
Type of drug?
Codeine
Opioid
Type of drug?
Hydrocodone
Opioid- synthetic
Type of drug?
Oxycodone
Opioid- synthetic
Type of drug?
Levorphanol
Opioid- synthetic
Type of drug?
Fentanyl
Opioid
100 times more potent than morphine
Type of drug?
Meperidine
Opioid
Reaction w/ MAOI's
Type of drug?
Propoxyphene
Opioid
Metabolite is cardiotoxic
Type of drug?
Methadone
Opioid
Used to treat heroin addiction
Type of drug?
Pentazocine
Opioid- Partial agonist
Type of drug?
Buprenorphine
Opioid- Partial agonist
Type of drug?
Dextromethorphan
Opioid
Antitussive
The "DM" in cough syrup
Type of drug?
Diphenoxylate
Opioid
Antidiarrheal
Type of drug?
Loperamide
Opioid
Antidiarrheal
Type of drug?
Naloxone
Opioid antagonist
Shorter acting
Type of drug?
Naltrexone
Opioid antagonist
Longer acting
Tx of Phenobarbital OD?
Alkalinization of urine
Type of drug?
Ibutilide
Class III antiarrhythmic
Potassium channel blocker
Type of drug?
Adenosine
Antiarrhythmic- no class
drug of choice in diagnosing/abolishing AV nodal arrhythmias
Type of drug?
Diphenhydramine
1st generation H1 blocker
Used for allergies, motion sickness & sleep aide
Type of drug?
Dimenhydrinate
1st generation H1 blocker
Used for allergies, motion sickness & sleep aide
Type of drug?
Chlorpheniramine
1st generation H1 blocker
Used for allergies, motion sickness & sleep aide
Type of drug?
Loratadine
2nd generation H1 blocker
Used for allergies
Type of drug?
Fexofenadine
2nd generation H1 blocker
Used for allergies
Type of drug?
Desloratadine
2nd generation H1 blocker
Used for allergies
Type of drug?
Acetazolamide
Carbonic anhydrase inhibitor
Diuretic
Type of drug?
Furosemide
Loop diuretic
Type of drug?
Ethacrynic acid
Loop diuretic
Is not a sulfonamide like the other loop diuretics
Type of drug?
Bumetamide
Loop diuretic
Type of drug?
Torsemide
Loop diuretic
Type of drug?
Hydrochlorothiazide
Thiazide diuretic
Type of drug?
Chlorothiazide
Thiazide diuretic
Type of drug?
Metolazone
Thiazide diuretic
Type of drug?
Chlorotalidone
Thiazide diuretic
Type of drug?
Spironolactone
K+ sparing diuretic
Competitive aldosterone antagonist
Also inhibits steroid synthesis →tx for PCOS to prevent hirsutism
Type of drug?
Triamterene
K+ sparing diuretic
Blocks sodium channel in principal cells
Type of drug?
Amiloride
K+ sparing diuretic
Blocks sodium channel in principal cells
Type of drug?
Eplereone
K+ sparing diuretic
Competitive aldosterone antagonist
Type of drug?
Losartan
Angiotensin II receptor antagonist
Antidote for Acetaminophen?
N-acetylcysteine
Antidote for Salicylate?
Alkalinize urine & dialysis
Antidote for Anticholinesterase?
Atropine(choline antagonist) & pralidoxime
Antidote for Anticholinergic?
Physostigmine salicylate (anticholinesterase)
Antidote for B-blockers?
Glucagon
Antidote for Digitalis?
Stop digitalis, normalize K+, lidocaine, anti-digitalis Fab fragments, Mg2+
Antidote for Iron?
Deferoxamine
Antidote for Lead?
CaEDTA, Dimercapro, succimer(for kids) & penicillamine
Antidote for Arsenic?
Dimercaprol, succimer & penicillamine
Antidote for Gold?
Dimercaprol, succimer & penicillamine
Antidote for Mercury?
Dimercaprol & succimer
Antidote for Copper?
Penicillamine
Antidote for Cyanide?
Nitrite, hydroxocobalmin, thiosulfate
Antidote for Methemoglobin?
Methylene blue
Antidote for Carbon monoxide?
100% oxygen/hyperbaric O2
Antidote for Methanol?
Ethanol, dialysis & fomepizole
Antidote for Ethylene glycol?
Ethanol, dialysis & fomepizole
Antidote for Opioids?
Naloxone/Naltrexone
Antidote for Benzodiazepine?
Flumazenil
Antidote for TCA's?
NaHCO3
Antidote for Heparin?
Protamine
Antidote for Warfarin?
Vitamin K & fresh frozen plasma
Antidote for tPA?
Aminocaproic acid
Antidote for Streptokinase?
Aminocaproic acid
What is Echinacea used for?
Herbal agent used for common cold
What is Ephedra used for?
Herbal agent used for weight loss
What is Feverfew used for?
Herbal agent used for migraines
What is Ginkgo used for?
Herbal agent used for intermittent claudication
What is Kava used for?
Herbal agent used for chronic anxiety
What is Milk thistle used for?
Herbal agent used for viral hepatitis
What is Saw palmetto used for?
Herbal agent used for benign prostatic hyperplasia
What is St. Johns wart used for?
Herbal agent used for mild/moderate depression
What is DHEA used for?
Herbal agent used for symptomatic improvement in females w/ SLE or AIDS
What is Melatonin used for?
Herbal agent used for Jet lag & insomnia
Type of drug?
Hemicholinium
Autonomic drug
Blocks the uptake of choline into cholinergic nerves
Type of drug?
Vesamicol
Autonomic drug
Blocks the uptake of acetylcholine into vesicles in cholinergic nerves
Type of drug?
Botulinum
Autonomic drug
Blocks the release of ACh vesicles from nerve terminal of cholinergic nerves
Type of drug?
Metyrosine
Autonomic drug
Blocks the conversion of tyrosine to dopamine (on it's way to become NE) in noradrenergic nerves
Type of drug?
Cocaine
Autonomic drug
Blocks the reuptake of NE from the synaptic space into presynaptic nerves
Type of drug?
Amphetamine
Autonomic drug
Stimulates the release of vesicular NE, epinephrine & dopamine from nerve endings
Also blocks MAO
Type of drug?
Bethanechol
Cholinergic agonist
Activates bowel & bladder smooth muscle
Type of drug?
Carbachol
Cholinergic agonist
Used for glaucoma
Type of drug?
Pilocarpine
Cholinergic agonist
Treats Acute glaucoma
Type of drug?
Methacholine
Cholinergic agonist
Causes bronchioconstriction when inhaled; used for asthma challenge test
Type of drug?
Neostigmine
Anti-cholinesterase
Used for urinary retention, myasthenia gravis, neuromuscular blockade reversal
Type of drug?
Pyridostigmine
Anti-cholinesterase
Used for myasthenia gravis
Type of drug?
Edrophonium
Anti-cholinesterase
Short acting; for diagnosis of myasthenia gravis
Type of drug?
Physostigmine
Anti-cholinesterase
Used for glaucoma & atropine overdose
Type of drug?
Echothiophate
Anti-cholinesterase
Used for glaucoma
Type of drug?
Atropine
Cholinergic antagonist- blocks parasympathetics
Blocks "SLUD"
Type of drug?
Homatropine
Cholinergic antagonist- like atropine
Type of drug?
Tropicamide
Cholinergic antagonist- like atropine
Type of drug?
Benztropine
Cholinergic antagonist- like atropine
Works on CNS- used on Parkinson's disease
Type of drug?
Scopolamine
Cholinergic antagonist- like atropine
Works on CNS- used on motion sickness
Type of drug?
Ipratropium
Cholinergic antagonist- like atropine
Works on respiratory system- used on asthma & COPD
Type of drug?
Methscopolamine
Cholinergic antagonist- like atropine
Works on GU system- reduces urgency in cystitis & bladder spasms
Type of drug?
Oxybutin
Cholinergic antagonist- like atropine
Works on GU system- reduces urgency in cystitis & bladder spasms
Type of drug?
Glycopyrrolate
Cholinergic antagonist- like atropine
Works on GU system- reduces urgency in cystitis & bladder spasms
Type of drug?
Brimonidine
Alpha-agonist
Tx for glaucoma
Type of drug?
Latanoprost
Prostaglandin F2-alpha
Tx for glaucoma
Type of drug?
Hexamethonium
Nicotinic ACh receptor antagonist- ganglion blocker
Type of drug?
Isoproterenol
Beta agonist
Used for AV block & asthma
Type of drug?
Dobutamine
Beta agonist (β1>β2)
Used for shock & heart failure cardiac stress testing
Type of drug?
Ephedrine
Sympathomimetic- releases stored catecholamines
Type of drug?
Phenylephrine
Alpha agonist (α1>α2)
Used for nasal decongestion
Type of drug?
Mirtazapine
α2 selective antagonist
Used to treat depression
Type of drug?
Statins
Lipid lowering agent
Blocks HMG-CoA reductase
Type of drug?
Niacin
Lipid lowering agent
Inhibits release of FA from adipose & TG from liver
Type of drug?
Cholestyramine
Lipid lowering agent
Bile acid resin- keeps bile from getting reabsorbed
Type of drug?
Colestipol
Lipid lowering agent
Bile acid resin- keeps bile from getting reabsorbed
Type of drug?
Ezetimibe
Lipid lowering agent
Selectively inhibits intestinal cholesterol absorption
Type of drug?
Fibrates
Lipid lowering agent
PPAR-alpha agonist- leads to increased beta-oxidation transcription of LPL
Type of drug?
Salmeterol
Beta-2 agonist- Asthma drug
Type of drug?
Guaifenesin
Expectorant- removes excess sputum
Type of drug?
N-acetylcystine
Expectorant- Mucolytic; loosens mucus plugs in CF pts
Type of drug?
Buspirone
Anti-anxiety drug
Partial Serotonin-1a agonist
Used for generalized anxiety
Type of drug?
Bupropion
Heterocyclic antidepressant
Also for smoking cessation
Type of drug?
Venlafaxine
Heterocyclic antidepressant
Inhibits serotonin, NE & dopamine reuptake
Also for generalized anxiety
Type of drug?
Mirtazapine
Heterocyclic antidepressant
α2 & 5HT&3 antagonist
Type of drug?
Maprotiline
Heterocyclic antidepressant
NE reuptake inhibitor
Type of drug?
Trazodone
Heterocyclic antidepressant
Serotonin reuptake inhibitor
What neurotransmitter?
Sympathetic preganglionic nerves
Acetylcholine on nicotinic receptors
What neurotransmitter?
Parasympathetic preganglionic nerves
Acetylcholine on nicotinic receptors
What neurotransmitter?
Parasympathetic postganglionic nerves
Acetylcholine on muscarinic receptors
What neurotransmitter?
Sympathetic nerves acting on sweat glands
Acetylcholine on muscarinic receptors
What neurotransmitter?
Sympathetics acting on renal vascular smooth muscle
Dopamine
What neurotransmitter?
Sympathetic postganglionic nerves
NE on alpha & beta receptors
What neurotransmitter?
Sympathetics acting on the adrenal medulla
Acetylcholine on nicotinic receptors
What neurotransmitter?
Somatic nervous system acting on skeletal muscle
Acetylcholine on nicotinic receptors
What G-protein is a/w:
α1 receptor
q
What G-protein is a/w:
α2 receptor
i
What G-protein is a/w:
β1 receptor
s
What G-protein is a/w:
β2 receptor
s
What G-protein is a/w:
M1 receptor
q
What G-protein is a/w:
M2 receptor
i
What G-protein is a/w:
M3 receptor
q
What G-protein is a/w:
D1 receptor
s
What G-protein is a/w:
D2 receptor
i
What G-protein is a/w:
H1 receptor
q
What G-protein is a/w:
H2 receptor
s
What G-protein is a/w:
V1 receptor
q
What G-protein is a/w:
V2 receptor
s
Gq protein
H1, α1, V1, M1 & M3
Phospholipase C, PIP2, IP3(Ca) & DAG(protein kinase C)
Gs protein
β1, β2, D1, H2 & V2
Adenyl cyclase, cAMP & protein kinase A
Gi protein
M2, α2 & D2
Decreased adenyl cyclase, cAMP & proein kinase A
Type of Drug?
Bromocriptine
Parkinson's Tx
Partial dopamine agonist
Type of Drug?
Amantadine
Parkinson's Tx
Increases dopamine release
Type of Drug?
Levodopa
Parkinson's Tx
Converted to dopamine inside the brain by dopa decarboxylase
Type of Drug?
Carbidopa
Parkinson's Tx
Inhibitor of peripheral dopa decarboxylase- blocks conversion of levodopa to dopamine outside the brain; decreases SE's of levodopa
Type of Drug?
Selegiline
Parkinson's Tx
Selectively inhibits MAO-B which leads to increased availability of dopamine
Type of Drug?
Benztropine
Parkinson's Tx
Antimuscarinic; improves tremor & rigidity
Type of Drug?
Sumatriptan
Tx of acute migraines & cluster headaches
Serotonin-1D agonist leads to vasoconstriction
Type of Drug?
Phenytoin
Anti-epileptic drug
Blocks Na channels & inhibits glutamate release
Tx of tonic-clonic & status epilepticus prophylaxis
Type of Drug?
Carbamazepine
Anti-epileptic drug
Increased Na channel inactivation
Tx of tonic-clonic(1st) & trigeminal neuralgia(1st)
Type of Drug?
Lamotrigine
Anti-epileptic drug
Blocks Na channels
Tx of tonic-clonic & partial seizures
Type of Drug?
Gabapentin
Anti-epileptic drug
Increases GABA release
Tx of tonic-clonic, partial seizures & peripheral neuropathy
Type of Drug?
Topiramate
Anti-epileptic drug
Blocks Na channels & increases GABA action
Tx of tonic-clonic & partial seizures
Type of Drug?
Valproic acid
Anti-epileptic drug
Increases Na channel inactivation & GABA conc.
Tx of tonic-clonic(1st), Absence, partial, & myoclonic
Type of Drug?
Ethosuximide
Anti-epileptic drug
Blocks thalamic Ca channels
Tx of absence seizures(1st)
Type of Drug?
Halothane
Inhaled anesthetic
Myocardial & respiratory depression, nausea/emesis, increases cerebral blood flow
What drug is used for tx of acute status epilepticus?
Benzodiazepines
Type of Drug?
Isoflurane
Inhaled anesthetic
Type of Drug?
Nitrous oxide
Inhaled anesthetic
Type of Drug?
Arylcyclohexamine
IV anesthetic
Ketamine; PCP analogs
Type of Drug?
Propofol
IV anesthetic
Used for rapid anesthesia inductions & short procedures
Type of Drug?
Succinylcholine
Depolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors
Type of Drug?
Tubocurarine
Nondepolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors
Type of drug?
Procaine, Cocaine, Tetracaine
Ester local anesthetics
Intracellularly binds and blocks Na channels
Type of drug?
Lidocaine, Mepivacaine, Bupivacaine
Amide local anesthetics
Intracellularly binds and blocks Na channels
Type of drug?
Dantrolene
Tx for malignant hyperthermia & neuroleptic malignant sydrome
Blocks Ca release from sarcoplamic reticulum of skeletal muscle
Type of drug?
Atracurium
Nondepolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors
Type of drug?
Pancuronium
Nondepolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors
Type of drug?
Ondansetron
5HT3 Blocker
Prevents emesis from chemo
Type of drug?
Cimetidine
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells
Type of drug?
Ranitidine
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells
Type of drug?
Famotidine
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells
Type of drug?
Nizatidine
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells
Type of drug?
Omeprazole
Proton pump inhibitor
Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Type of drug?
Lansoprazole
Proton pump inhibitor
Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Type of drug?
Bismuth
Binds to base of peptic ulcers to protect and allow for reestablishment of pH
Type of drug?
Sucralfate
Binds to base of peptic ulcers to protect and allow for reestablishment of pH
Type of drug?
Misoprostol
PGE1 analog; increases gastric mucous barrier & decreases acid production
Prevents NSAID ulcers, maintains PDA, Induces labor
Type of drug?
Pirenzepine
Muscarinic antagonist
Blocks M1 receptors on ECL cells(↓Histamine) & M3 receptors on parietal cells (↓acid)
Type of drug?
Propanthaline
Blocks M1 receptors on ECL cells(↓Histamine) & M3 receptors on parietal cells (↓acid)
Type of drug?
Infliximab
Monoclonal Ab to TNF-alpha
Tx of crohn's & RA
Type of drug?
Sulfasalazine
Combo of antibiotic & anti-inflammatory; activated by colonic bacteria
Tx of Ulcerative colitis & Crohn's
Type of drug?
Cisapride
Pro-kinetic agent
Acts on serotonin receptors →↑ACh release →↑GI tone
Type of drug?
Metoclopramide
Pro-kinetic agent
D2 antagonist→↑GI tone
What is the triple therapy for H. pylori ulcers?
Metronidazole
Bismuth or sucralfate
Amoxicillin(or tetracycline)
Which H2 blocker is a potent inhibitor of P-450?
Cimetidine
Type of drug?
Lispro
Short- acting Insulin
Type of drug?
NPH
Intermediate- acting Insulin
Type of drug?
Lente
Long- acting Insulin
Type of drug?
Ultralente
Long- acting Insulin
Type of drug?
Tolbutamide
1st gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization)
Type of drug?
Chlorporpamide
1st gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization)
Type of drug?
Glyburide
2nd gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization)
Type of drug?
Glimepiride
2nd gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization)
Type of drug?
Glipizide
2nd gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization)
Type of drug?
Metformin
Biguanide- DM treatment
↑ insulin sensitivity
Type of drug?
Pioglitazone
Glitazone- DM treatment
↑ insulin sensitivity
Type of drug?
Rosiglitazone
Glitazone- DM treatment
↑ insulin sensitivity
Type of drug?
Acarbose
Alpha-glucosidase inhibitor
↓GI absorption of glucose to ↓ postprandial hyperglycemia
Type of drug?
Miglitol
Alpha-glucosidase inhibitor
↓GI absorption of glucose to ↓ postprandial hyperglycemia
Type of drug?
Orlistat
Obesity management
Inhibits pancreatic lipases→ altered fat metabolism
Type of drug?
Sibutramine
Obesity management
Sympathomimetic serotonin & NE reuptake inhibitor
Type of drug?
Propylthiouracil
Hyperthyroid tx; Inhibits thyroid peroxidase(↓iodine conversion & thyroid hormone coupling); also ↓peripheral conversion of T4 to T3
Type of drug?
Methimazole
Hyperthyroid tx; Inhibits thyroid peroxidase(↓iodine conversion & thyroid hormone coupling); also ↓peripheral conversion of T4 to T3
Type of drug?
Octreotide
Somatostatin
Tx of acromegaly, carcinoid, gastinoma & glucagonoma
Type of drug?
Oxytocin
Stimulates labor, uterine contractions, milk let-down, controls uterine hemorrhage
Type of drug?
Desmopressin
ADH
Tx of central diabetes insipidus
Type of drug?
Levothyroxine
Thyroid hormone replacement
Type of drug?
Hydrocortisone
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma
Type of drug?
Prednisone
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma
Type of drug?
Triamcinolone
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma
Type of drug?
Dexamethasone
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma
Type of drug?
Beclomethasone
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma
Type of drug?
Repaglinide
Meglitinide- DM treatment
Same mech as sulfonylureas
Type of drug?
Nateglinide
Meglitinide- DM treatment
Same mech as sulfonylureas
Type of drug?
Exenatide
Oral hypoglycemia
Sythetic similar to glucagon-like peptide-1; stimulates insulin secretion
Type of drug?
Pramlintide
Oral hypoglycemia
Amylinomimetic agent; suppreses postprandial glucagon & hepatic glucose output
Type of drug?
Sermorelin
Synthetic Growth hormone-releasing hormone
Type of drug?
Protirelin
Synthetic Thyrotropin-releasing hormone
Type of drug?
Corticorelin
Synthetic Corticotropin-releasing hormone
Type of drug?
Finasteride
Anti-androgen
5alpha-reductase inhibitor →↓conversion of testosterone to DHT
Tx of BPH
Type of drug?
Flutamide
Anti-androgen
Nonsteroidal competitive inhibitor of androgen at the testosterone receptor
Tx of prostate carcinoma
Type of drug?
Ketoconazole
Anti-androgen
Inhibits steroid synthesis
Tx of PCOS to prevent hirsutism
Type of drug?
Leuprolide
GnRH analog; ↑gonadotropin release when used in pulsatile fashion; ↓release when used continuously
Type of drug?
Sildenafil
Inhibits cGMP phosphodiesterase→ vasodilation
Tx of ED
Type of drug?
Vardenafil
Inhibits cGMP phosphodiesterase→ vasodilation
Tx of ED
Type of drug?
Clomiphene
Partial Estrogen receptor agonist in pituitary gland →↓feedback inhibition →↑gonadotropins →ovulation
Tx of infertility
Type of drug?
Mifepristone
RU-486; Prevents implantation
Competitive inhibitor of progestins
Type of drug?
Tadalafil
Inhibits cGMP phosphodiesterase→ vasodilation
Tx of ED
Type of drug?
Alendronate
Bisphosphonate
Affinity for Hydroxyapatite; inhibits osteoclast activity
Type of drug?
Ibandronate
Bisphosphonate
Affinity for Hydroxyapatite; inhibits osteoclast activity
Type of drug?
Risedronate
Bisphosphonate
Affinity for Hydroxyapatite; inhibits osteoclast activity
Type of drug?
Methotrexate
Cancer drug- Antimetabolite
Folic acid analog, blocks dihydrofolate reductase
Type of drug?
5-Fluorouracil
Cancer drug- Antimetabolite
Pyrimidine analog, inhibits thymidylate synthase
Type of drug?
6-mercaptopurine
Cancer drug- Antimetabolite
Blocks de novo purine synthesis, activated by HGPRTase
Type of drug?
Cytarabine
Cancer drug- Antimetabolite
Inhibits DNA polymerase
Type of drug?
Gemcitabine
Cancer drug- Antimetabolite
Inhibits DNA polymerase
Type of drug?
Cyclophosphamide
Cancer drug- Alkylating agent
Covalently X-links DNA at guanine N-7
Type of drug?
Ifosfamide
Cancer drug- Alkylating agent
Covalently X-links DNA at guanine N-7
Type of drug?
Carmustine
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors
Type of drug?
Lomustine
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors
Type of drug?
Semustine
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors
Type of drug?
Streptozocin
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors
Type of drug?
Cisplatin
Cancer drug
Acts like an alkylating agent
Type of drug?
Carboplatin
Cancer drug
Acts like an alkylating agent
Type of drug?
Busulfan
Cancer drug- alkylating agent
Type of drug?
Doxorubicin
Cancer drug- Intercalates DNA
Also generates free radicals
Type of drug?
Daunorubicin
Cancer drug- Intercalates DNA
Also generates free radicals
Type of drug?
Dactinomycin
Cancer drug- Intercalates DNA
Type of drug?
Bleomycin
Cancer drug- Intercalates DNA
Also generates free radicals
Type of drug?
Etoposide
Cancer drug- Topoisomerase II inhibitor
Type of drug?
Teniposide
Cancer drug- Topoisomerase II inhibitor
Type of drug?
Topotecan
Cancer drug- Topoisomerase I inhibitor
Type of drug?
Irinotecan
Cancer drug- Topoisomerase I inhibitor
Type of drug?
Tamoxifene
Cancer drug- Anti-estrogen
Estrogen antagonist in breast, agonist in bone
Type of drug?
Raloxifene
Cancer drug- Anti-estrogen
Estrogen antagonist in breast, agonist in bone
Type of drug?
Trastuzumab
Cancer drug- Monoclonal Ab against HER-2(erb-B2); kills breast cancer cells w/ overexpression of receptor
Type of drug?
Imatinib
Cancer drug- Philidelphia chromosome brc-abl tyrosine kinase inhibitor
Type of drug?
Vincristine
Cancer drug- binds to tubulin & blocks polymerization of microtubules so mitotic spindle can't form
Type of drug?
Vinblastine
Cancer drug- binds to tubulin & blocks polymerization of microtubules so mitotic spindle can't form
Type of drug?
Paclitaxel
Cancer drug- binds to tubulin & hyperstabilizes polymerized microtubules so that mitotic spindle can't break down
Type of drug?
Docetaxel
Cancer drug- binds to tubulin & hyperstabilizes polymerized microtubules so that mitotic spindle can't break down
Type of drug?
Methicillin
Penicillinase-resistant penicillin
Type of drug?
Nafcillin
Penicillinase-resistant penicillin
Type of drug?
Dicloxacillin
Penicillinase-resistant penicillin
Type of drug?
Ampicillin
Aminopenicillin
Type of drug?
Amoxicillin
Aminopenicillin
Type of drug?
Ticarcillin
Anti-pseudomonal penicillin
Type of drug?
Cabenicillin
Anti-pseudomonal penicillin
Type of drug?
Piperacillin
Anti-pseudomonal penicillin
Type of drug?
Cephalosporins
Beta-lactam drugs that are less susceptible to penicillinases
Type of drug?
Aztreonam
Monobactam resistant to beta-lactamases
Type of drug?
Vancomycin
Cell wall inhibitor- binds D-ala D-ala portion of cell wall precursors
Type of drug?
Streptomycin
Aminoglycoside
30S protein synthesis inhibitor
Type of drug?
Gentamicin
Aminoglycoside
30S protein synthesis inhibitor
Type of drug?
Tetracycline
30S protein synthesis inhibitor
Type of drug?
Chloramphenicol
50S protein synthesis inhibitor
Type of drug?
Erythromycin
Macrolide
50S protein synthesis inhibitor
Type of drug?
Lincomycin
50S protein synthesis inhibitor
Type of drug?
Clindamycin
50S protein synthesis inhibitor
Type of drug?
Neomycin
Aminoglycoside
30S protein synthesis inhibitor
Type of drug?
Doxycycline
Tetracycline
30S protein synthesis inhibitor
Type of drug?
Demeclocycline
Tetracycline
30S protein synthesis inhibitor
Type of drug?
Minocycline
Tetracycline
30S protein synthesis inhibitor
Type of drug?
Azithromycin
Macrolide
50S protein synthesis inhibitor
Type of drug?
Clarithromycin
Macrolide
50S protein synthesis inhibitor
Type of drug?
Sulfamethoxazole
Sulfonamide
PABA antimetabolites inhibit dihydropteroate synthase
Type of drug?
Trimethoprim
Inhibits bacterial dihydrofolate reductase
Type of drug?
Ciprofloxacin
Fluoroquinolone
Inhibits DNA gyrase(topoisomerase II)
Type of drug?
Nalidixic acid
Quinolone
Inhibits DNA gyrase(topoisomerase II)
What cancer drugs have the SE of Hemorrhagic cystitis?
Cyclophosphamide & Ifosfamide
Partially prevented by mesna
What cancer drugs have the SE CNS toxicity?
Nitrosureas
What cancer drugs have the SE acoustic nerve damage?
Cisplatin & Carboplatin
What cancer drugs have the SE Nephrotoxicity?
Cisplatin & Carboplatin
What cancer drugs have the SE Pulmonary fibrosis?
Busulfan & Bleomycin
What cancer drugs have the SE Cardiotoxicity?
Doxorubicin, Daunorubicin & Trastuzumab
What cancer drugs have the SE increased risk of endometrial cancer?
Tamoxifene
What cancer drugs have the SE Alopecia?
Doxorubicin, Daunorubicin & Etoposide