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474 Cards in this Set
- Front
- Back
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Drugs ending with:
-ane |
Inhalational general anesthetic
Ex-Halothane |
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Drugs ending with:
-azepam |
Benzodiazepine
Ex-Diazepam |
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Drugs ending with:
-azine |
Phenothiazine(neuroleptic, antiemetic)
Ex-Chlorpromazine |
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Drugs ending with:
-azole |
Antifungal
Ex-Ketoconazole |
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Drugs ending with:
-barbital |
Barbiturate
Ex-Phenobarbital |
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Drugs ending with:
-caine |
Local anesthetic
Ex-Lidocaine |
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Drugs ending with:
-cillin |
Penicillin drug
Ex-Methicillin |
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Drugs ending with:
-cycline |
Antibiotic (protein synthesis inhibitor)
Ex-Tetracycline |
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Drugs ending with:
-ipramine |
Tricyclic antidepressant
Ex-Imipramine |
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Drugs ending with:
-navir |
Protease inhibitor
Ex-Saquinavir |
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Drugs ending with:
-olol |
Beta-blocker
Ex-Propanolol |
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Drugs ending with:
-operidol |
Butyrophenone (neuroleptic)
Ex-Haloperidol |
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Drugs ending with:
-oxin |
Cardiac glycoside(+ inotrope)
Ex-Digoxin |
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Drugs ending with:
-phylline |
Methylxanthine
Ex-Theophylline |
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Drugs ending with:
-pril |
ACE inhibitor
Ex-Captopril |
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Drugs ending with:
-terol |
Beta-2 agonist
Ex-Albuterol |
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Drugs ending with:
-tidine |
H2 antagonist
Ex-Cimetidine |
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Drugs ending with:
-triptyline |
Tricyclic antidepressant
Ex-Amitriptyline |
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Drugs ending with:
-tropin |
Pituitary hormone
Ex-Somatotropin |
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Drugs ending with:
-zosin |
alpha-1 antagonist
Ex-Prazosin |
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What drug causes:
Atropine like side effects |
Tricyclics
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What drug causes:
Cardiac toxicity |
Doxorubicin(Adriamycin), Daunorubicin
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What drug causes:
Coronary vasospasm |
Cocaine
|
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What drug causes:
Cutaneous flushing |
Niacin, Calcium channel blockers, adenosine, vancomycin
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What drug causes:
Torsades des pointes |
Class Ia(quinidine) & Class III(Sotalolo) antiarrhythmics; cisapride
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What drug causes:
Agranulocytosis |
Clozapine, Carbamazepine, Colchicine
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What drug causes:
Aplastic anemia |
Chloramphenicol, Benzene, NSAID's
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What drug causes:
Grey baby syndrome |
Chloramphenicol- transferred through the placenta
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What drug causes:
Hemolysis in G6PD-deficient pts |
Sulfonamides, Isoniazid(INH), aspirin, ibuprofen, primaquine, nitrofurantoin
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What drug causes:
Thrombotic complications |
OCP's
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What drug causes:
Coughing |
ACE Inhibitors
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What drug causes:
Pulmonary fibrosis |
Bleomycin, amiodarone, busulfan
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What drug causes:
Acute cholestatic hepatitis |
Macrolides
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What drug causes:
Focal to massie hepatic necrosis |
Halothane, Valproic acid, acetaminophen, Amanita phalloides
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What drug causes:
Hepatitis |
Isoniazid (INH)
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What drug causes:
Pseudomembranous colitis |
Clindamycin, ampicillin
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What drug causes:
Adrenocortical insufficiency |
Glucocorticoid withdrawl
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What drug causes:
Gynecomastia |
"Some Drugs Create Awesome Knockers"
Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, Estrogens, Ketoconazole |
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What drug causes:
Hot flashes |
Tamoxifen
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What drug causes:
Gingival Hyperplasia |
Phenytoin
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What drug causes:
Osteoporosis |
Corticosteroids, Heparin
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What drug causes:
Photosensitivity |
"SAT for a photo"
Sulfonamides, Amiodarone, Tetracycline |
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What drug causes:
SLE-like syndrome |
"HIPP"
Hydralazine, Isoniazid(INH), Procainamide, Phenytoin |
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What drug causes:
Tendonitis, tendon rupture & cartilage damage in kids |
Fluoroquinolones
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What drug causes:
Fanconi's Syndrome |
Expired tetracycline
Fanconi's syndrome- Multiple defects of tubular function |
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What drug causes:
Interstitial nephritis |
Methicillin
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What drug causes:
Hemorrhagic Cystitis |
Cyclophosphamide, Ifosfamide
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What drug causes:
Cinchonism |
Quinidine, Quinine
Cinchonism- tinnitus, headache, deafness & occasionally anaphylactoid shock |
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What drug causes:
Diabetes insipidus |
Lithium, Demeclocycline
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What drug causes:
Seizures |
Bupropion, Imipenem/Cilastatin
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What drug causes:
Tardive dyskinesia |
Antipsychotics(more likely w/ typical antipsychotics)
Tardive dyskinesia- involuntary movements of the facial muscles & tongue |
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What drug causes:
Disulfiram-like reaction |
Metronidazole, Certain cephalosporins, Procarbazine, Sulfonylureas
Disulfiram-like reactions- Increased drinking hangovers |
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What drug causes:
Nephrotoxicity/Neurotoxicity |
Polymyxins
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What drug causes:
Nephrotoxicity/Ototoxicity |
Aminoglycosides, Loop diuretics, Cisplatin
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P450 inducers
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"Queen Barb takes Phen-phen and Refuses Greasy Carbs"
Quinidine, Barbiturates, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, St. Johns Wart |
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P450 inhibitors
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"Inhibitors stop Cyber-Kids from Eating Grapefruit"
Isoniazid, Sulfonamides, Cimetidine, Ketoconazole, Erythromycin, Grapefruit juice |
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P450 Inducer or Inhibitor:
Quinidine |
P450 Inducer
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P450 Inducer or Inhibitor:
Barbiturates |
P450 Inducer
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P450 Inducer or Inhibitor:
Phenytoin |
P450 Inducer
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P450 Inducer or Inhibitor:
Rifampin |
P450 Inducer
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P450 Inducer or Inhibitor:
Griseofulvin |
P450 Inducer
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P450 Inducer or Inhibitor:
Carbamazepine |
P450 Inducer
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P450 Inducer or Inhibitor:
St. John's Wart |
P450 Inducer
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P450 Inducer or Inhibitor:
Isoniazid |
P450 Inhibitor
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P450 Inducer or Inhibitor:
Sulfonamides |
P450 Inhibitor
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P450 Inducer or Inhibitor:
Cimetidine |
P450 Inhibitor
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P450 Inducer or Inhibitor:
Ketoconazole |
P450 Inhibitor
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P450 Inducer or Inhibitor:
Erythromycin |
P450 Inhibitor
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P450 Inducer or Inhibitor:
Grapefruit Juice |
P450 Inhibitor
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Drugs with what qualities have the highest volume of distribution?
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Fat soluble & basic drugs
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Type of drug?
Prazosin |
alpha-1 selective antagonist
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Type of drug?
Terazosin |
alpha-1 selective antagonist
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Type of drug?
Doxazosin |
alpha-1 selective antagonist
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Type of drug?
Phenoxybenzamine |
alpha non-selective antagonist
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Type of drug?
Phentolamine |
alpha non-selective antagonist
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Type of drug?
Clonidine |
Central alpha-2 agonist
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Type of drug?
Guanbenz |
Central alpha-2 agonist
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Type of drug?
Guanfacine |
Central alpha-2 agonist
|
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Type of drug?
Methyldopa |
Central alpha-2 agonist
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Type of drug?
Trimethaphan |
Ganglionic blocker
|
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Type of drug?
Reserpine |
Postganglionic sympathetic neuron blocker;
Inhibits uptake of dopamine into vesicles for conversion to NE |
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Type of drug?
Guanethidine |
Postganglionic sympathetic neuron blocker;
Inhibits release of NE into synapse |
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Type of drug?
Hydralazine |
Vasodilator
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Antihypertensive drug that can cause a (+) coombs test & hemolysis
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Methyldopa
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Type of drug?
Nitroprusside |
Vasodilator
Metabolized into CN |
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Type of drug?
Minoxidil |
Vasodilator
Inhibits phosphodieseterase |
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Type of drug?
Verapamil |
Calcium channel blocker
Class IV AA & vasodilator |
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Type of drug?
Diltiazem |
Calcium channel blocker
Class IV AA & vasodilator |
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Type of drug?
Nifedipine |
Calcium channel blocker
Vasodilator only (no AA activity like the other calcium channel blockers) |
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Type of drug?
Nitroglycerin |
Antianginal drug- Nitrates
Metabolized into NO |
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Type of drug?
Isosorbide dinitrate |
Antianginal drug- Nitrates
Metabolized into NO |
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Type of drug?
Digoxin |
Cardiac glycoside for heart failure
Blocks Na/K pump which increases Na/Ca pump leading to increased Ca & therefore contractility |
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Type of drug?
Quinidine |
Class Ia antiarrhythmic
Na channel blocker |
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Type of drug?
Procainamide |
Class Ia antiarrhythmic
Na channel blocker |
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Type of drug?
Disopyramide |
Class Ia antiarrhythmic
Na channel blocker |
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Type of drug?
Lidocaine |
Class Ib antiarrhythmic
Na channel blocker |
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Type of drug?
Mexiletine |
Class Ib antiarrhythmic
Na channel blocker |
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Type of drug?
Tocainide |
Class Ib antiarrhythmic
Na channel blocker |
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Type of drug?
Flecainide |
Class Ic antiarrhythmic
Na channel blocker |
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Type of drug?
Encainide |
Class Ic antiarrhythmic
Na channel blocker |
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Type of drug?
Propafenone |
Class Ic antiarrhythmic
Na channel blocker |
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Type of drug?
Sotalol |
Class III antiarrhythmic
Potassium channel blocker |
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Type of drug?
Bretylium |
Class III antiarrhythmic
Potassium channel blocker |
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Type of drug?
Amiodarone |
Class III antiarrhythmic
Potassium channel blocker |
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EKG effect of Class Ia antiarrhythmic?
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Widened QRS; increased QT
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EKG effect of Class Ib antiarrhythmic?
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None of the main ones
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EKG effect of Class Ic antiarrhythmic?
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Widened QRS; Increased PR & QT
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EKG effect of Class II antiarrhythmic?
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Increased PR
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EKG effect of Class III antiarrhythmic?
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Increased PR & QT
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EKG effect of Class IV antiarrhythmic?
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Increased PR
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Type of drug?
Ticlopidine |
Antiplatelet drug
Interferes w/ ADP-induced binding of fibrinogen to platelets |
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Type of drug?
Clopidogrel |
Antiplatelet drug
Interferes w/ ADP-induced binding of fibrinogen to platelets |
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Type of drug?
Abciximab |
Antiplatelet drug- Fiban drug
Monoclonal Ab that inhibits fibrinogen binding to GpIIb/IIIa |
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Type of drug?
Tirofibin |
Antiplatelet drug- Fiban drug
Monoclonal Ab that inhibits fibrinogen binding to GpIIb/IIIa |
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Type of drug?
Streptokinase |
Fibrinolytic- Systemic agent
|
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Type of drug?
Urokinase |
Fibrinolytic- Systemic agent
|
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Type of drug?
Alteplase |
Fibrinolytic- Tissue agent
|
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Type of drug?
Reteplase |
Fibrinolytic- Tissue agent
|
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Type of drug?
Albuterol |
Beta-2 agonist- asthma drug
|
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Type of drug?
Metaproterenol |
Beta-2 agonist- asthma drug
|
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Type of drug?
Terbutaline |
Beta-2 agonist- asthma drug
|
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Type of drug?
Theophlline |
Methylxanthine- asthma drug
|
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Type of drug?
Aminophylline |
Methylxanthine- asthma drug
|
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Type of drug?
Ipratropium |
Muscarinic antagonist- asthma drug
|
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Type of drug?
Tiotropium |
Muscarinic antagonist- asthma drug
|
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Type of drug?
Fluticasone |
Anti-inflammatory corticosteroids- asthma drug
|
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Type of drug?
Cromolyn |
Anti-inflammatory mast cell stabilizer- asthma drug
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Type of drug?
Nedocromil |
Anti-inflammatory mast cell stabilizer- asthma drug
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Type of drug?
Zileuton |
Anti-inflammatory leukotriene synthesis inhibitor- asthma drug
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Type of drug?
Zafirlukast |
Anti-inflammatory leukotriene receptor antagonist- asthma drug
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Type of drug?
Montelukast |
Anti-inflammatory leukotriene receptor antagonist- asthma drug
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Type of drug?
Omalizunab |
Anti-inflammatory Anti-IgE
Blocks IgE attachment to mast cells & basophils |
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Type of drug?
Thioridazine |
Antipsychotic- Phenothiazine
Most cardiotoxic neuroleptic |
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Type of drug?
Fluphenazine |
Antipsychotic- Phenothiazine
Most cardiotoxic neuroleptic |
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Type of drug?
Chlorpromazine |
Antipsychotic- Phenothiazine
Most cardiotoxic neuroleptic |
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Type of drug?
Olanzapine |
Atypical Antipsychotic
|
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Type of drug?
Risperidone |
Atypical Antipsychotic
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Type of drug?
Fluoxetine |
SSRI
|
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Type of drug?
Paroxetine |
SSRI
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Type of drug?
Citalopram |
SSRI
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Type of drug?
Imipramine |
Tricyclic antidepressant
|
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Type of drug?
Desipramine |
Tricyclic antidepressant
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Type of drug?
Nortriptyline |
Tricyclic antidepressant
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Type of drug?
Clomipramine |
Tricyclic antidepressant
|
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Type of drug?
Doxepin |
Tricyclic antidepressant
|
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Type of drug?
Trancypromine |
MAOI
|
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Type of drug?
Haloperidol |
Antipsychotic
|
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Type of drug?
Clozapine |
Atypical antipsychotic
|
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Type of drug?
Sertraline |
SSRI
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What 2 drugs can be used in obsessive compulsive disorder
|
Olanzapine (atypical antipsychotic) & Clomipramine (TCA)
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What TCA can also be used to treat bed wetting?
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Imipramine
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What is the least sedating TCA?
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Desipramine
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Which TCA has the least anticholinergic SE's?
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Nortriptyline
Drug of choice in elderly to avoid confusion & hallucinations |
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What drugs cause neuroleptic malignant syndrome?
|
Haloperidol, Phenothiazines (e.g. thoridazine), & thiothixene
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Type of drug?
Lithium |
Mood stabilizer
5HT-1a agonist |
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Type of drug?
Phenelzine |
MAOI
|
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Type of drug?
Selegiline |
MAOI (selective for MAO-B)
|
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What drug causes increased frequency of GABA channel opening?
|
Benzodiazepines
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What drug causes prolonged duration of GABA channel opening?
|
Barbiturates
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Type of drug?
Oxazepam |
Benzodiazepine
Short acting (3-8 hrs) |
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Type of drug?
Lorazepam |
Benzodiazepine
Intermediate acting (12-24 hrs) |
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Type of drug?
Alprazolam |
Benzodiazepine
Intermediate acting (12-24 hrs) |
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Type of drug?
Chlorazepate |
Benzodiazepine
Long acting (1-3 days) |
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Type of drug?
Chlordiazepoxide |
Benzodiazepine
Long acting (1-3 days) |
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Type of drug?
Diazepam |
Benzodiazepine
Long acting (1-3 days) |
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Type of drug?
Flurazepam |
Benzodiazepine
Long acting (1-3 days) |
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Type of drug?
Thiopental |
Barbiturate
Ultrashort acting |
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Type of drug?
Pentobarbital |
Barbiturate
Short acting |
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Type of drug?
Secobarbital |
Barbiturate
Short acting |
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Type of drug?
Amobarbital |
Barbiturate
Intermediate acting |
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Type of drug?
Butalbital |
Barbiturate
Intermediate acting |
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Type of drug?
Phenobarbital |
Barbiturate
Long acting |
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Type of drug?
Heroin |
Opioid
|
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Type of drug?
Morphine |
Opioid
|
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Type of drug?
Codeine |
Opioid
|
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Type of drug?
Hydrocodone |
Opioid- synthetic
|
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Type of drug?
Oxycodone |
Opioid- synthetic
|
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Type of drug?
Levorphanol |
Opioid- synthetic
|
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Type of drug?
Fentanyl |
Opioid
100 times more potent than morphine |
|
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Type of drug?
Meperidine |
Opioid
Reaction w/ MAOI's |
|
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Type of drug?
Propoxyphene |
Opioid
Metabolite is cardiotoxic |
|
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Type of drug?
Methadone |
Opioid
Used to treat heroin addiction |
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Type of drug?
Pentazocine |
Opioid- Partial agonist
|
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Type of drug?
Buprenorphine |
Opioid- Partial agonist
|
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Type of drug?
Dextromethorphan |
Opioid
Antitussive The "DM" in cough syrup |
|
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Type of drug?
Diphenoxylate |
Opioid
Antidiarrheal |
|
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Type of drug?
Loperamide |
Opioid
Antidiarrheal |
|
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Type of drug?
Naloxone |
Opioid antagonist
Shorter acting |
|
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Type of drug?
Naltrexone |
Opioid antagonist
Longer acting |
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Tx of Phenobarbital OD?
|
Alkalinization of urine
|
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Type of drug?
Ibutilide |
Class III antiarrhythmic
Potassium channel blocker |
|
|
Type of drug?
Adenosine |
Antiarrhythmic- no class
drug of choice in diagnosing/abolishing AV nodal arrhythmias |
|
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Type of drug?
Diphenhydramine |
1st generation H1 blocker
Used for allergies, motion sickness & sleep aide |
|
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Type of drug?
Dimenhydrinate |
1st generation H1 blocker
Used for allergies, motion sickness & sleep aide |
|
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Type of drug?
Chlorpheniramine |
1st generation H1 blocker
Used for allergies, motion sickness & sleep aide |
|
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Type of drug?
Loratadine |
2nd generation H1 blocker
Used for allergies |
|
|
Type of drug?
Fexofenadine |
2nd generation H1 blocker
Used for allergies |
|
|
Type of drug?
Desloratadine |
2nd generation H1 blocker
Used for allergies |
|
|
Type of drug?
Acetazolamide |
Carbonic anhydrase inhibitor
Diuretic |
|
|
Type of drug?
Furosemide |
Loop diuretic
|
|
|
Type of drug?
Ethacrynic acid |
Loop diuretic
Is not a sulfonamide like the other loop diuretics |
|
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Type of drug?
Bumetamide |
Loop diuretic
|
|
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Type of drug?
Torsemide |
Loop diuretic
|
|
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Type of drug?
Hydrochlorothiazide |
Thiazide diuretic
|
|
|
Type of drug?
Chlorothiazide |
Thiazide diuretic
|
|
|
Type of drug?
Metolazone |
Thiazide diuretic
|
|
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Type of drug?
Chlorotalidone |
Thiazide diuretic
|
|
|
Type of drug?
Spironolactone |
K+ sparing diuretic
Competitive aldosterone antagonist Also inhibits steroid synthesis →tx for PCOS to prevent hirsutism |
|
|
Type of drug?
Triamterene |
K+ sparing diuretic
Blocks sodium channel in principal cells |
|
|
Type of drug?
Amiloride |
K+ sparing diuretic
Blocks sodium channel in principal cells |
|
|
Type of drug?
Eplereone |
K+ sparing diuretic
Competitive aldosterone antagonist |
|
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Type of drug?
Losartan |
Angiotensin II receptor antagonist
|
|
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Antidote for Acetaminophen?
|
N-acetylcysteine
|
|
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Antidote for Salicylate?
|
Alkalinize urine & dialysis
|
|
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Antidote for Anticholinesterase?
|
Atropine(choline antagonist) & pralidoxime
|
|
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Antidote for Anticholinergic?
|
Physostigmine salicylate (anticholinesterase)
|
|
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Antidote for B-blockers?
|
Glucagon
|
|
|
Antidote for Digitalis?
|
Stop digitalis, normalize K+, lidocaine, anti-digitalis Fab fragments, Mg2+
|
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Antidote for Iron?
|
Deferoxamine
|
|
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Antidote for Lead?
|
CaEDTA, Dimercapro, succimer(for kids) & penicillamine
|
|
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Antidote for Arsenic?
|
Dimercaprol, succimer & penicillamine
|
|
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Antidote for Gold?
|
Dimercaprol, succimer & penicillamine
|
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Antidote for Mercury?
|
Dimercaprol & succimer
|
|
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Antidote for Copper?
|
Penicillamine
|
|
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Antidote for Cyanide?
|
Nitrite, hydroxocobalmin, thiosulfate
|
|
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Antidote for Methemoglobin?
|
Methylene blue
|
|
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Antidote for Carbon monoxide?
|
100% oxygen/hyperbaric O2
|
|
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Antidote for Methanol?
|
Ethanol, dialysis & fomepizole
|
|
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Antidote for Ethylene glycol?
|
Ethanol, dialysis & fomepizole
|
|
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Antidote for Opioids?
|
Naloxone/Naltrexone
|
|
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Antidote for Benzodiazepine?
|
Flumazenil
|
|
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Antidote for TCA's?
|
NaHCO3
|
|
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Antidote for Heparin?
|
Protamine
|
|
|
Antidote for Warfarin?
|
Vitamin K & fresh frozen plasma
|
|
|
Antidote for tPA?
|
Aminocaproic acid
|
|
|
Antidote for Streptokinase?
|
Aminocaproic acid
|
|
|
What is Echinacea used for?
|
Herbal agent used for common cold
|
|
|
What is Ephedra used for?
|
Herbal agent used for weight loss
|
|
|
What is Feverfew used for?
|
Herbal agent used for migraines
|
|
|
What is Ginkgo used for?
|
Herbal agent used for intermittent claudication
|
|
|
What is Kava used for?
|
Herbal agent used for chronic anxiety
|
|
|
What is Milk thistle used for?
|
Herbal agent used for viral hepatitis
|
|
|
What is Saw palmetto used for?
|
Herbal agent used for benign prostatic hyperplasia
|
|
|
What is St. Johns wart used for?
|
Herbal agent used for mild/moderate depression
|
|
|
What is DHEA used for?
|
Herbal agent used for symptomatic improvement in females w/ SLE or AIDS
|
|
|
What is Melatonin used for?
|
Herbal agent used for Jet lag & insomnia
|
|
|
Type of drug?
Hemicholinium |
Autonomic drug
Blocks the uptake of choline into cholinergic nerves |
|
|
Type of drug?
Vesamicol |
Autonomic drug
Blocks the uptake of acetylcholine into vesicles in cholinergic nerves |
|
|
Type of drug?
Botulinum |
Autonomic drug
Blocks the release of ACh vesicles from nerve terminal of cholinergic nerves |
|
|
Type of drug?
Metyrosine |
Autonomic drug
Blocks the conversion of tyrosine to dopamine (on it's way to become NE) in noradrenergic nerves |
|
|
Type of drug?
Cocaine |
Autonomic drug
Blocks the reuptake of NE from the synaptic space into presynaptic nerves |
|
|
Type of drug?
Amphetamine |
Autonomic drug
Stimulates the release of vesicular NE, epinephrine & dopamine from nerve endings Also blocks MAO |
|
|
Type of drug?
Bethanechol |
Cholinergic agonist
Activates bowel & bladder smooth muscle |
|
|
Type of drug?
Carbachol |
Cholinergic agonist
Used for glaucoma |
|
|
Type of drug?
Pilocarpine |
Cholinergic agonist
Treats Acute glaucoma |
|
|
Type of drug?
Methacholine |
Cholinergic agonist
Causes bronchioconstriction when inhaled; used for asthma challenge test |
|
|
Type of drug?
Neostigmine |
Anti-cholinesterase
Used for urinary retention, myasthenia gravis, neuromuscular blockade reversal |
|
|
Type of drug?
Pyridostigmine |
Anti-cholinesterase
Used for myasthenia gravis |
|
|
Type of drug?
Edrophonium |
Anti-cholinesterase
Short acting; for diagnosis of myasthenia gravis |
|
|
Type of drug?
Physostigmine |
Anti-cholinesterase
Used for glaucoma & atropine overdose |
|
|
Type of drug?
Echothiophate |
Anti-cholinesterase
Used for glaucoma |
|
|
Type of drug?
Atropine |
Cholinergic antagonist- blocks parasympathetics
Blocks "SLUD" |
|
|
Type of drug?
Homatropine |
Cholinergic antagonist- like atropine
|
|
|
Type of drug?
Tropicamide |
Cholinergic antagonist- like atropine
|
|
|
Type of drug?
Benztropine |
Cholinergic antagonist- like atropine
Works on CNS- used on Parkinson's disease |
|
|
Type of drug?
Scopolamine |
Cholinergic antagonist- like atropine
Works on CNS- used on motion sickness |
|
|
Type of drug?
Ipratropium |
Cholinergic antagonist- like atropine
Works on respiratory system- used on asthma & COPD |
|
|
Type of drug?
Methscopolamine |
Cholinergic antagonist- like atropine
Works on GU system- reduces urgency in cystitis & bladder spasms |
|
|
Type of drug?
Oxybutin |
Cholinergic antagonist- like atropine
Works on GU system- reduces urgency in cystitis & bladder spasms |
|
|
Type of drug?
Glycopyrrolate |
Cholinergic antagonist- like atropine
Works on GU system- reduces urgency in cystitis & bladder spasms |
|
|
Type of drug?
Brimonidine |
Alpha-agonist
Tx for glaucoma |
|
|
Type of drug?
Latanoprost |
Prostaglandin F2-alpha
Tx for glaucoma |
|
|
Type of drug?
Hexamethonium |
Nicotinic ACh receptor antagonist- ganglion blocker
|
|
|
Type of drug?
Isoproterenol |
Beta agonist
Used for AV block & asthma |
|
|
Type of drug?
Dobutamine |
Beta agonist (β1>β2)
Used for shock & heart failure cardiac stress testing |
|
|
Type of drug?
Ephedrine |
Sympathomimetic- releases stored catecholamines
|
|
|
Type of drug?
Phenylephrine |
Alpha agonist (α1>α2)
Used for nasal decongestion |
|
|
Type of drug?
Mirtazapine |
α2 selective antagonist
Used to treat depression |
|
|
Type of drug?
Statins |
Lipid lowering agent
Blocks HMG-CoA reductase |
|
|
Type of drug?
Niacin |
Lipid lowering agent
Inhibits release of FA from adipose & TG from liver |
|
|
Type of drug?
Cholestyramine |
Lipid lowering agent
Bile acid resin- keeps bile from getting reabsorbed |
|
|
Type of drug?
Colestipol |
Lipid lowering agent
Bile acid resin- keeps bile from getting reabsorbed |
|
|
Type of drug?
Ezetimibe |
Lipid lowering agent
Selectively inhibits intestinal cholesterol absorption |
|
|
Type of drug?
Fibrates |
Lipid lowering agent
PPAR-alpha agonist- leads to increased beta-oxidation transcription of LPL |
|
|
Type of drug?
Salmeterol |
Beta-2 agonist- Asthma drug
|
|
|
Type of drug?
Guaifenesin |
Expectorant- removes excess sputum
|
|
|
Type of drug?
N-acetylcystine |
Expectorant- Mucolytic; loosens mucus plugs in CF pts
|
|
|
Type of drug?
Buspirone |
Anti-anxiety drug
Partial Serotonin-1a agonist Used for generalized anxiety |
|
|
Type of drug?
Bupropion |
Heterocyclic antidepressant
Also for smoking cessation |
|
|
Type of drug?
Venlafaxine |
Heterocyclic antidepressant
Inhibits serotonin, NE & dopamine reuptake Also for generalized anxiety |
|
|
Type of drug?
Mirtazapine |
Heterocyclic antidepressant
α2 & 5HT&3 antagonist |
|
|
Type of drug?
Maprotiline |
Heterocyclic antidepressant
NE reuptake inhibitor |
|
|
Type of drug?
Trazodone |
Heterocyclic antidepressant
Serotonin reuptake inhibitor |
|
|
What neurotransmitter?
Sympathetic preganglionic nerves |
Acetylcholine on nicotinic receptors
|
|
|
What neurotransmitter?
Parasympathetic preganglionic nerves |
Acetylcholine on nicotinic receptors
|
|
|
What neurotransmitter?
Parasympathetic postganglionic nerves |
Acetylcholine on muscarinic receptors
|
|
|
What neurotransmitter?
Sympathetic nerves acting on sweat glands |
Acetylcholine on muscarinic receptors
|
|
|
What neurotransmitter?
Sympathetics acting on renal vascular smooth muscle |
Dopamine
|
|
|
What neurotransmitter?
Sympathetic postganglionic nerves |
NE on alpha & beta receptors
|
|
|
What neurotransmitter?
Sympathetics acting on the adrenal medulla |
Acetylcholine on nicotinic receptors
|
|
|
What neurotransmitter?
Somatic nervous system acting on skeletal muscle |
Acetylcholine on nicotinic receptors
|
|
|
What G-protein is a/w:
α1 receptor |
q
|
|
|
What G-protein is a/w:
α2 receptor |
i
|
|
|
What G-protein is a/w:
β1 receptor |
s
|
|
|
What G-protein is a/w:
β2 receptor |
s
|
|
|
What G-protein is a/w:
M1 receptor |
q
|
|
|
What G-protein is a/w:
M2 receptor |
i
|
|
|
What G-protein is a/w:
M3 receptor |
q
|
|
|
What G-protein is a/w:
D1 receptor |
s
|
|
|
What G-protein is a/w:
D2 receptor |
i
|
|
|
What G-protein is a/w:
H1 receptor |
q
|
|
|
What G-protein is a/w:
H2 receptor |
s
|
|
|
What G-protein is a/w:
V1 receptor |
q
|
|
|
What G-protein is a/w:
V2 receptor |
s
|
|
|
Gq protein
|
H1, α1, V1, M1 & M3
Phospholipase C, PIP2, IP3(Ca) & DAG(protein kinase C) |
|
|
Gs protein
|
β1, β2, D1, H2 & V2
Adenyl cyclase, cAMP & protein kinase A |
|
|
Gi protein
|
M2, α2 & D2
Decreased adenyl cyclase, cAMP & proein kinase A |
|
|
Type of Drug?
Bromocriptine |
Parkinson's Tx
Partial dopamine agonist |
|
|
Type of Drug?
Amantadine |
Parkinson's Tx
Increases dopamine release |
|
|
Type of Drug?
Levodopa |
Parkinson's Tx
Converted to dopamine inside the brain by dopa decarboxylase |
|
|
Type of Drug?
Carbidopa |
Parkinson's Tx
Inhibitor of peripheral dopa decarboxylase- blocks conversion of levodopa to dopamine outside the brain; decreases SE's of levodopa |
|
|
Type of Drug?
Selegiline |
Parkinson's Tx
Selectively inhibits MAO-B which leads to increased availability of dopamine |
|
|
Type of Drug?
Benztropine |
Parkinson's Tx
Antimuscarinic; improves tremor & rigidity |
|
|
Type of Drug?
Sumatriptan |
Tx of acute migraines & cluster headaches
Serotonin-1D agonist leads to vasoconstriction |
|
|
Type of Drug?
Phenytoin |
Anti-epileptic drug
Blocks Na channels & inhibits glutamate release Tx of tonic-clonic & status epilepticus prophylaxis |
|
|
Type of Drug?
Carbamazepine |
Anti-epileptic drug
Increased Na channel inactivation Tx of tonic-clonic(1st) & trigeminal neuralgia(1st) |
|
|
Type of Drug?
Lamotrigine |
Anti-epileptic drug
Blocks Na channels Tx of tonic-clonic & partial seizures |
|
|
Type of Drug?
Gabapentin |
Anti-epileptic drug
Increases GABA release Tx of tonic-clonic, partial seizures & peripheral neuropathy |
|
|
Type of Drug?
Topiramate |
Anti-epileptic drug
Blocks Na channels & increases GABA action Tx of tonic-clonic & partial seizures |
|
|
Type of Drug?
Valproic acid |
Anti-epileptic drug
Increases Na channel inactivation & GABA conc. Tx of tonic-clonic(1st), Absence, partial, & myoclonic |
|
|
Type of Drug?
Ethosuximide |
Anti-epileptic drug
Blocks thalamic Ca channels Tx of absence seizures(1st) |
|
|
Type of Drug?
Halothane |
Inhaled anesthetic
Myocardial & respiratory depression, nausea/emesis, increases cerebral blood flow |
|
|
What drug is used for tx of acute status epilepticus?
|
Benzodiazepines
|
|
|
Type of Drug?
Isoflurane |
Inhaled anesthetic
|
|
|
Type of Drug?
Nitrous oxide |
Inhaled anesthetic
|
|
|
Type of Drug?
Arylcyclohexamine |
IV anesthetic
Ketamine; PCP analogs |
|
|
Type of Drug?
Propofol |
IV anesthetic
Used for rapid anesthesia inductions & short procedures |
|
|
Type of Drug?
Succinylcholine |
Depolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors |
|
|
Type of Drug?
Tubocurarine |
Nondepolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors |
|
|
Type of drug?
Procaine, Cocaine, Tetracaine |
Ester local anesthetics
Intracellularly binds and blocks Na channels |
|
|
Type of drug?
Lidocaine, Mepivacaine, Bupivacaine |
Amide local anesthetics
Intracellularly binds and blocks Na channels |
|
|
Type of drug?
Dantrolene |
Tx for malignant hyperthermia & neuroleptic malignant sydrome
Blocks Ca release from sarcoplamic reticulum of skeletal muscle |
|
|
Type of drug?
Atracurium |
Nondepolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors |
|
|
Type of drug?
Pancuronium |
Nondepolarizing Neuromuscular blocking drug
Selective for motor nicotinic receptors |
|
|
Type of drug?
Ondansetron |
5HT3 Blocker
Prevents emesis from chemo |
|
|
Type of drug?
Cimetidine |
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells |
|
|
Type of drug?
Ranitidine |
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells |
|
|
Type of drug?
Famotidine |
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells |
|
|
Type of drug?
Nizatidine |
Reversible H2 blocker
Decreases acid secretion by stomach parietal cells |
|
|
Type of drug?
Omeprazole |
Proton pump inhibitor
Irreversibly inhibits H+/K+ ATPase in stomach parietal cells |
|
|
Type of drug?
Lansoprazole |
Proton pump inhibitor
Irreversibly inhibits H+/K+ ATPase in stomach parietal cells |
|
|
Type of drug?
Bismuth |
Binds to base of peptic ulcers to protect and allow for reestablishment of pH
|
|
|
Type of drug?
Sucralfate |
Binds to base of peptic ulcers to protect and allow for reestablishment of pH
|
|
|
Type of drug?
Misoprostol |
PGE1 analog; increases gastric mucous barrier & decreases acid production
Prevents NSAID ulcers, maintains PDA, Induces labor |
|
|
Type of drug?
Pirenzepine |
Muscarinic antagonist
Blocks M1 receptors on ECL cells(↓Histamine) & M3 receptors on parietal cells (↓acid) |
|
|
Type of drug?
Propanthaline |
Blocks M1 receptors on ECL cells(↓Histamine) & M3 receptors on parietal cells (↓acid)
|
|
|
Type of drug?
Infliximab |
Monoclonal Ab to TNF-alpha
Tx of crohn's & RA |
|
|
Type of drug?
Sulfasalazine |
Combo of antibiotic & anti-inflammatory; activated by colonic bacteria
Tx of Ulcerative colitis & Crohn's |
|
|
Type of drug?
Cisapride |
Pro-kinetic agent
Acts on serotonin receptors →↑ACh release →↑GI tone |
|
|
Type of drug?
Metoclopramide |
Pro-kinetic agent
D2 antagonist→↑GI tone |
|
|
What is the triple therapy for H. pylori ulcers?
|
Metronidazole
Bismuth or sucralfate Amoxicillin(or tetracycline) |
|
|
Which H2 blocker is a potent inhibitor of P-450?
|
Cimetidine
|
|
|
Type of drug?
Lispro |
Short- acting Insulin
|
|
|
Type of drug?
NPH |
Intermediate- acting Insulin
|
|
|
Type of drug?
Lente |
Long- acting Insulin
|
|
|
Type of drug?
Ultralente |
Long- acting Insulin
|
|
|
Type of drug?
Tolbutamide |
1st gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization) |
|
|
Type of drug?
Chlorporpamide |
1st gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization) |
|
|
Type of drug?
Glyburide |
2nd gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization) |
|
|
Type of drug?
Glimepiride |
2nd gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization) |
|
|
Type of drug?
Glipizide |
2nd gen. Sulfonylurea
Increase insulin release(closes K channel→ Ca influx →cell depolarization) |
|
|
Type of drug?
Metformin |
Biguanide- DM treatment
↑ insulin sensitivity |
|
|
Type of drug?
Pioglitazone |
Glitazone- DM treatment
↑ insulin sensitivity |
|
|
Type of drug?
Rosiglitazone |
Glitazone- DM treatment
↑ insulin sensitivity |
|
|
Type of drug?
Acarbose |
Alpha-glucosidase inhibitor
↓GI absorption of glucose to ↓ postprandial hyperglycemia |
|
|
Type of drug?
Miglitol |
Alpha-glucosidase inhibitor
↓GI absorption of glucose to ↓ postprandial hyperglycemia |
|
|
Type of drug?
Orlistat |
Obesity management
Inhibits pancreatic lipases→ altered fat metabolism |
|
|
Type of drug?
Sibutramine |
Obesity management
Sympathomimetic serotonin & NE reuptake inhibitor |
|
|
Type of drug?
Propylthiouracil |
Hyperthyroid tx; Inhibits thyroid peroxidase(↓iodine conversion & thyroid hormone coupling); also ↓peripheral conversion of T4 to T3
|
|
|
Type of drug?
Methimazole |
Hyperthyroid tx; Inhibits thyroid peroxidase(↓iodine conversion & thyroid hormone coupling); also ↓peripheral conversion of T4 to T3
|
|
|
Type of drug?
Octreotide |
Somatostatin
Tx of acromegaly, carcinoid, gastinoma & glucagonoma |
|
|
Type of drug?
Oxytocin |
Stimulates labor, uterine contractions, milk let-down, controls uterine hemorrhage
|
|
|
Type of drug?
Desmopressin |
ADH
Tx of central diabetes insipidus |
|
|
Type of drug?
Levothyroxine |
Thyroid hormone replacement
|
|
|
Type of drug?
Hydrocortisone |
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma |
|
|
Type of drug?
Prednisone |
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma |
|
|
Type of drug?
Triamcinolone |
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma |
|
|
Type of drug?
Dexamethasone |
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma |
|
|
Type of drug?
Beclomethasone |
Glucocorticoid
Tx of addison's, inflammation, immune suppresion, asthma |
|
|
Type of drug?
Repaglinide |
Meglitinide- DM treatment
Same mech as sulfonylureas |
|
|
Type of drug?
Nateglinide |
Meglitinide- DM treatment
Same mech as sulfonylureas |
|
|
Type of drug?
Exenatide |
Oral hypoglycemia
Sythetic similar to glucagon-like peptide-1; stimulates insulin secretion |
|
|
Type of drug?
Pramlintide |
Oral hypoglycemia
Amylinomimetic agent; suppreses postprandial glucagon & hepatic glucose output |
|
|
Type of drug?
Sermorelin |
Synthetic Growth hormone-releasing hormone
|
|
|
Type of drug?
Protirelin |
Synthetic Thyrotropin-releasing hormone
|
|
|
Type of drug?
Corticorelin |
Synthetic Corticotropin-releasing hormone
|
|
|
Type of drug?
Finasteride |
Anti-androgen
5alpha-reductase inhibitor →↓conversion of testosterone to DHT Tx of BPH |
|
|
Type of drug?
Flutamide |
Anti-androgen
Nonsteroidal competitive inhibitor of androgen at the testosterone receptor Tx of prostate carcinoma |
|
|
Type of drug?
Ketoconazole |
Anti-androgen
Inhibits steroid synthesis Tx of PCOS to prevent hirsutism |
|
|
Type of drug?
Leuprolide |
GnRH analog; ↑gonadotropin release when used in pulsatile fashion; ↓release when used continuously
|
|
|
Type of drug?
Sildenafil |
Inhibits cGMP phosphodiesterase→ vasodilation
Tx of ED |
|
|
Type of drug?
Vardenafil |
Inhibits cGMP phosphodiesterase→ vasodilation
Tx of ED |
|
|
Type of drug?
Clomiphene |
Partial Estrogen receptor agonist in pituitary gland →↓feedback inhibition →↑gonadotropins →ovulation
Tx of infertility |
|
|
Type of drug?
Mifepristone |
RU-486; Prevents implantation
Competitive inhibitor of progestins |
|
|
Type of drug?
Tadalafil |
Inhibits cGMP phosphodiesterase→ vasodilation
Tx of ED |
|
|
Type of drug?
Alendronate |
Bisphosphonate
Affinity for Hydroxyapatite; inhibits osteoclast activity |
|
|
Type of drug?
Ibandronate |
Bisphosphonate
Affinity for Hydroxyapatite; inhibits osteoclast activity |
|
|
Type of drug?
Risedronate |
Bisphosphonate
Affinity for Hydroxyapatite; inhibits osteoclast activity |
|
|
Type of drug?
Methotrexate |
Cancer drug- Antimetabolite
Folic acid analog, blocks dihydrofolate reductase |
|
|
Type of drug?
5-Fluorouracil |
Cancer drug- Antimetabolite
Pyrimidine analog, inhibits thymidylate synthase |
|
|
Type of drug?
6-mercaptopurine |
Cancer drug- Antimetabolite
Blocks de novo purine synthesis, activated by HGPRTase |
|
|
Type of drug?
Cytarabine |
Cancer drug- Antimetabolite
Inhibits DNA polymerase |
|
|
Type of drug?
Gemcitabine |
Cancer drug- Antimetabolite
Inhibits DNA polymerase |
|
|
Type of drug?
Cyclophosphamide |
Cancer drug- Alkylating agent
Covalently X-links DNA at guanine N-7 |
|
|
Type of drug?
Ifosfamide |
Cancer drug- Alkylating agent
Covalently X-links DNA at guanine N-7 |
|
|
Type of drug?
Carmustine |
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors |
|
|
Type of drug?
Lomustine |
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors |
|
|
Type of drug?
Semustine |
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors |
|
|
Type of drug?
Streptozocin |
Cancer drug- Alkylating agent
Nitrosurea- used on brain tumors |
|
|
Type of drug?
Cisplatin |
Cancer drug
Acts like an alkylating agent |
|
|
Type of drug?
Carboplatin |
Cancer drug
Acts like an alkylating agent |
|
|
Type of drug?
Busulfan |
Cancer drug- alkylating agent
|
|
|
Type of drug?
Doxorubicin |
Cancer drug- Intercalates DNA
Also generates free radicals |
|
|
Type of drug?
Daunorubicin |
Cancer drug- Intercalates DNA
Also generates free radicals |
|
|
Type of drug?
Dactinomycin |
Cancer drug- Intercalates DNA
|
|
|
Type of drug?
Bleomycin |
Cancer drug- Intercalates DNA
Also generates free radicals |
|
|
Type of drug?
Etoposide |
Cancer drug- Topoisomerase II inhibitor
|
|
|
Type of drug?
Teniposide |
Cancer drug- Topoisomerase II inhibitor
|
|
|
Type of drug?
Topotecan |
Cancer drug- Topoisomerase I inhibitor
|
|
|
Type of drug?
Irinotecan |
Cancer drug- Topoisomerase I inhibitor
|
|
|
Type of drug?
Tamoxifene |
Cancer drug- Anti-estrogen
Estrogen antagonist in breast, agonist in bone |
|
|
Type of drug?
Raloxifene |
Cancer drug- Anti-estrogen
Estrogen antagonist in breast, agonist in bone |
|
|
Type of drug?
Trastuzumab |
Cancer drug- Monoclonal Ab against HER-2(erb-B2); kills breast cancer cells w/ overexpression of receptor
|
|
|
Type of drug?
Imatinib |
Cancer drug- Philidelphia chromosome brc-abl tyrosine kinase inhibitor
|
|
|
Type of drug?
Vincristine |
Cancer drug- binds to tubulin & blocks polymerization of microtubules so mitotic spindle can't form
|
|
|
Type of drug?
Vinblastine |
Cancer drug- binds to tubulin & blocks polymerization of microtubules so mitotic spindle can't form
|
|
|
Type of drug?
Paclitaxel |
Cancer drug- binds to tubulin & hyperstabilizes polymerized microtubules so that mitotic spindle can't break down
|
|
|
Type of drug?
Docetaxel |
Cancer drug- binds to tubulin & hyperstabilizes polymerized microtubules so that mitotic spindle can't break down
|
|
|
Type of drug?
Methicillin |
Penicillinase-resistant penicillin
|
|
|
Type of drug?
Nafcillin |
Penicillinase-resistant penicillin
|
|
|
Type of drug?
Dicloxacillin |
Penicillinase-resistant penicillin
|
|
|
Type of drug?
Ampicillin |
Aminopenicillin
|
|
|
Type of drug?
Amoxicillin |
Aminopenicillin
|
|
|
Type of drug?
Ticarcillin |
Anti-pseudomonal penicillin
|
|
|
Type of drug?
Cabenicillin |
Anti-pseudomonal penicillin
|
|
|
Type of drug?
Piperacillin |
Anti-pseudomonal penicillin
|
|
|
Type of drug?
Cephalosporins |
Beta-lactam drugs that are less susceptible to penicillinases
|
|
|
Type of drug?
Aztreonam |
Monobactam resistant to beta-lactamases
|
|
|
Type of drug?
Vancomycin |
Cell wall inhibitor- binds D-ala D-ala portion of cell wall precursors
|
|
|
Type of drug?
Streptomycin |
Aminoglycoside
30S protein synthesis inhibitor |
|
|
Type of drug?
Gentamicin |
Aminoglycoside
30S protein synthesis inhibitor |
|
|
Type of drug?
Tetracycline |
30S protein synthesis inhibitor
|
|
|
Type of drug?
Chloramphenicol |
50S protein synthesis inhibitor
|
|
|
Type of drug?
Erythromycin |
Macrolide
50S protein synthesis inhibitor |
|
|
Type of drug?
Lincomycin |
50S protein synthesis inhibitor
|
|
|
Type of drug?
Clindamycin |
50S protein synthesis inhibitor
|
|
|
Type of drug?
Neomycin |
Aminoglycoside
30S protein synthesis inhibitor |
|
|
Type of drug?
Doxycycline |
Tetracycline
30S protein synthesis inhibitor |
|
|
Type of drug?
Demeclocycline |
Tetracycline
30S protein synthesis inhibitor |
|
|
Type of drug?
Minocycline |
Tetracycline
30S protein synthesis inhibitor |
|
|
Type of drug?
Azithromycin |
Macrolide
50S protein synthesis inhibitor |
|
|
Type of drug?
Clarithromycin |
Macrolide
50S protein synthesis inhibitor |
|
|
Type of drug?
Sulfamethoxazole |
Sulfonamide
PABA antimetabolites inhibit dihydropteroate synthase |
|
|
Type of drug?
Trimethoprim |
Inhibits bacterial dihydrofolate reductase
|
|
|
Type of drug?
Ciprofloxacin |
Fluoroquinolone
Inhibits DNA gyrase(topoisomerase II) |
|
|
Type of drug?
Nalidixic acid |
Quinolone
Inhibits DNA gyrase(topoisomerase II) |
|
|
What cancer drugs have the SE of Hemorrhagic cystitis?
|
Cyclophosphamide & Ifosfamide
Partially prevented by mesna |
|
|
What cancer drugs have the SE CNS toxicity?
|
Nitrosureas
|
|
|
What cancer drugs have the SE acoustic nerve damage?
|
Cisplatin & Carboplatin
|
|
|
What cancer drugs have the SE Nephrotoxicity?
|
Cisplatin & Carboplatin
|
|
|
What cancer drugs have the SE Pulmonary fibrosis?
|
Busulfan & Bleomycin
|
|
|
What cancer drugs have the SE Cardiotoxicity?
|
Doxorubicin, Daunorubicin & Trastuzumab
|
|
|
What cancer drugs have the SE increased risk of endometrial cancer?
|
Tamoxifene
|
|
|
What cancer drugs have the SE Alopecia?
|
Doxorubicin, Daunorubicin & Etoposide
|
