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17 Cards in this Set
- Front
- Back
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Depression
Types? |
1. Reactive (triggered by events)
2. Major depressive (endogenous) 3. Manic depressive (bipolar affective) |
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Bipolar disorder
Types? |
Mania and Hypomania
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Drugs for Depression
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TCAs
MAOIs 2nd/3rd Gen antidepressants SSRIs SNRIs |
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Drugs for Bipolar
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Lithium
Anti-convulsants Atypical anti-psychotics |
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Tricyclic Antidepressants (TCAs)
Examples? Mech? |
e.g. NOR-AMI, DES-IMI
Amitriptyline, Nortriptyline Imipramine, Desipramine Mech: Blocks reuptake of NE and 5HT (seratonin) |
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TCAs
SEs? Interactions? |
Cardiotoxic (NE), Sedation (Histamine), Anticholinergic (Muscurinic)
Potentiates pressors, don't give with MAOIs |
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Monoamine Oxidase inhibitors A&B (MAOIs)
Examples? Mech? |
TRANYcypromine, PHENELazine, PARGYLine
Mech: Blocks MAO = ↑↑ NE, DA, 5HT |
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MAOIs
SEs? Interactions? |
NOT CARDIOTOXIC
anticholinergic, insomnia and orthostatic hypotension GREATLY potentiates pressors, don't give with TCAs, Avoid food rich in tyramine, may cause mania in ppl with hx of bipolar |
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2nd/3rd Gen antidepressants
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Mianserin (largely replaced)
SSRIs Bupropion (also smoking cessation) Trazodone (5HT reuptake inhibitor) |
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Specific Serotonin uptske inhibitors (SSRIs)
Examples? Mech? |
Fluoxetine (FLOSS)
Paroxetine (PARDOX) Fluovoxamine (FLOW FOX) Sertraline (SERTA) Citalopram (Citi LOW) Mech: 5HT uptake inhibitor (specific) |
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SSRIs
SEs? Interactions? |
Sexual dysfunction, anxiety, insomnia, headache, nausea, weight gain (pretend order of side effects is logical)
(NO orthostatic hypotension, anticholinergic, or cardiotoxicity) may block P450 and raise levels of other drugs |
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Serotonin Noradrenalin uptake inhibitors (SNRIs)
Example? Mech? |
VenLAFaxine (laugh)
low dose: 5HT uptake inhibitor high dose:5HT AND NE uptake inhibitor |
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SNRIs
SEs? |
Like SSRIs
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Lithium
Mech? |
↓↓ phosphotidylinositol system
PI --- PLC ---> DAG, IP3 doesn't stop manic per se but stop cycling = more normal states |
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Lithium
SEs? |
GI upsets, polyuria, polydipsia, fatigue, tremors
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Bipolar OTHER DRUGS
Anticonvulsants Atypical antipsychotics Tetracyclic Antidepressants (TeCA) |
1. Carba-ma-zepine, IAM-otrigine, Val-pro-ate
2. Risperidone, Olanzapin, quetiapine 3. Mirta-zapine |
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time of onset for ALL
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2 weeks + for effects! even though chemically immediate (unknown why)
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