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11 Cards in this Set
- Front
- Back
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MPTP is toxic to what part of the brain?
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nigrostriatal dopamine pathway; can cause Parkinson's
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Major excitatory neurotransmitters in hierarchal systems?
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aspartate and glutamate
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Major inhibitory neurotransmitters in hierarchal systems?
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GABA or glycine
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Major excitatory neurotransmitters in difuse systems?
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epinephrine and other amines; peptides
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3 criteria to be a neurotransmitter
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1) higher concentration in synapse than anywhere else. 2) released by electric/chemical stimulation via Ca-dependent mechanism. 3) must activate the synapse
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Ach binds what type of receptors?
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Nicotinic (ion channel) or Muscarinic (G protein)
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Main dopamine receptors in basal ganglia?
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D2
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Amphetamine has what effect on dopamine levels?
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increases
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Glutamic acid receptor type
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NMDA
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Which drugs block glutamic acid receptors?
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memantine; ketamine and PCP
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Baclofen mechanism
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activate GABA receptors for muscle relaxation
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