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39 Cards in this Set
- Front
- Back
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What 3 receptor type to opioids act on?
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Mu, Kappa, Delta
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Which receptor(s) (Mu, Kappa, Delta) can cause respiratory depression?
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Mu
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Which receptor(s) (Mu, Kappa, Delta) can cause decreased GI motility?
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Mu, Kappa
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Which receptor(s) (Mu, Kappa, Delta) can cause nausea/vomiting?
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Mu
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Which receptor(s) (Mu, Kappa, Delta) have antitussive effect?
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Mu, Kappa
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Which receptor(s) (Mu, Kappa, Delta) can cause sedation?
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Mu, Kappa
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Which receptor(s) (Mu, Kappa, Delta) can increase appetite?
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Mu, Kappa, Delta
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Which receptor(s) (Mu, Kappa, Delta) can cause miosis or mydriasis?
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Mu, Kappa
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Which receptor(s) (Mu, Kappa, Delta) can cause immunomodulation?
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Mu,Delta
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Which receptor(s) (Mu, Kappa, Delta) can cause Euphoria?
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Mu
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Which receptor(s) (Mu, Kappa, Delta) has an antidiuresis effect?
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Mu
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Which receptor(s) (Mu, Kappa, Delta) can cause a decrease in the urine voiding reflex?
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Mu
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Which receptor(s) (Mu, Kappa, Delta) can decrease uterine contractions?
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Mu
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Which receptor(s) (Mu, Kappa, Delta) can cause diuresis (decrease ADH release)?
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Kappa
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What is the mechanism of opioids?
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Mu, kappa (and delta) receptor agonists (and antagonists)
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What are opioids commonly used for?
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* Decrease diarrhea
* Antitussive (cough supressent) * Analgesia * Sedation * Calming/euphoria * Immobilization/chemical restraint * Inhibit GI motility * Increase locomotor activity |
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What are some common adverse effects of opioids?
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* Respiratory depression
* Nausea/vomiting * Dysphoria * CNS excitation * Dependence * Decreased urination * Hypotension |
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What opioid(s) are Mu agonists?
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* Morphine
* Hydromorphone * Codeine * Fentanyl * Buprenorphine * Tramadol |
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What opioid(s) are Kappa agonists?
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1. Butorphanol – full; also partial mu agonist
2. Nalbuphine - full; also partial antagonist of Mu |
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What opioid(s) are antagonists of all receptors?
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1. Naloxone – all receptors (partial mu)
2. Natrexone – partial; all receptors |
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What type of drug is Morphine?
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Mu agonist
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What is Morphine commonly used for?
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Analgesia
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What type of drug is Hydromorphone:?
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Mu agonist
More potent; less emetic than Morphine |
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What type of drug is Codeine?
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Mu agonist
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What drug effects are seen with Morphine and Hydromorphone?
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* Analgesia
* Respiratory depression * Decreased GI motility * Emesis (vomiting) * Antitussive |
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What type of drug is Fentanyl?
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Mu agonist
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What drug effects are seen with Fentanyl?
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* Analgesia
* Respiratory depression |
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What type of drug is Tramadol?
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Primarily Mu agonist
**Inhibits reuptake of norEPI and serotonin** |
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What drug effects are seen with Tramadol?
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*Analgesia
*Antitussive |
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What type of drug is Buprenorphrine?
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Partial Mu agonist; Kappa antagonist
***High affinity, potential longer pain control, more difficult reversal |
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What general effects are seen with use of Buprenorphrine?
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* Analgesia
* Sedation * Euphoria * GI effects * Respiratory depression |
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What type of drug is Butorphanol?
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Partial Mu agonist, Kappa agonist
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What general effects are seen with use of Buprenorphrine?
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* Antitussive
* Poor analgesic given PO * Reduced CNS excitement * Antiemetic (against vomiting and nausea) |
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What type of drug is Nalbuphrine?
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Mu antagonist, Kappa agonist
* Not a scheduled drug |
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What general effects are seen with use of Buprenorphrine?
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Analgesia (mild to moderate pain)
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What type of drug is Naloxone?
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Mu, Kappa, Delta antagonist
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What general effects are seen with use of Naloxone?
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* Can cause seizures
* Reverses opioid induced respiratory depression, while maintain some degree of analgesia (used as post-sx wake up drug) |
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What type of drug is Naltrexone?
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Mu, Kappa, Delta antagonist
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What is Naltrexone used for to reverse?
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Used to reverse Carfentanil
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