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22 Cards in this Set
- Front
- Back
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What does Digoxin do to cardiac function?
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Increased CO, control of arrhythmias, reduced blood volume, heart rate, venous pressure, and heart size, increased contractility
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MOA of digoxin?
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Inhibits Na/K ATPase
(Increased intracellular Na and Ca due to Na/Ca exchanger) |
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What is Digoxin used for?
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Treatment of congestive heart failure, atrial fibrillation, supraventricular, tachycardias
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Adverse effects of Digoxin?
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Arrhythmia, worsening of heart failure, GI upset
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What type of drug is Pimobendan?
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Vasodilator and positive inotrope = Inodilator
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MOA of Pimobendan?
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* Sensitizes cardiac contractile apparatus to intracellular Ca
* Inhibits Phosphodiesterase 3 |
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What is Pimobendan used for?
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Dogs with congestive heart failure secondary to dilated cardiomyopathy or chronic mitral valve insufficiency
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What does Pimobendan do to cardiac function?
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Decrease heart rate, increases contractility, atrial and venous vasodilation
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Adverse effects of Pimobendan?
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poor appetite, lethargy, diarrhea, dyspnea, azotemia, weakness, ascites
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What type of drug Hydralazine?
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Arteriole dilator
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What does Hydralazine do to cardiac function?
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Reduces peripheral vascular resistance and afterload, Increases stroke volume and CO
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MOA of Hydralazine
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Alter Ca metabolism in vascular smooth muscle
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Use of Hydralazine
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Reducer of afterload in congestive heart failure, especially in mitral valve insufficiency
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Adverse effects of Hydralazine?
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hypotension, reflex tachycardia, Na/H2O retention, GI upset
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What type of drug is Diltiazem?
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* Ca Channel blocker (L-type)- Vasodilator
* Inhibits influx of extracellular Ca into vascular smooth muscle and myocardial cells |
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What does Diltiazem do to cardiac function?
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Vasodilator and reduces contractility, heart rate, and afterload
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Use of Ditiazem?
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Hypertension, atrial fibrillation, supraventricular tachycardias
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Adverse Effects of Diliazem?
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Effects: bradycardia, vomiting (cats), hypotension, arrhythmias, elevates liver enzymes
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What type of drug is Amlodipine?
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Ca Channel Blocker-Inhibits Ca influx in cardiac and vascular smooth muscle
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What does amlodipine do to cardiac function?
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* Vasodilator and reduces conduction velocity in cardiac muscle
* Weak Cardiac activity |
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Uses of Amlodipine?
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Hypertension (cats), decreased blood pressure in renal disease (dogs)
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What type of drug is Carvedilol?
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* Beta 1 and 2 antagonist
* Alpha 1 antagonist |
