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45 Cards in this Set
- Front
- Back
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What are the adrenergic antagonists discussed in class?
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* Phenoxybenzamine
* Propranolol * Timolol * Atenolol * Carvedilol |
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What is the mechansim of action of adrenergic antagonists?
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Inhibit actions of agonists at adrenergic receptors (alpha and beta)
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What is the difference in mechansim of action of selective and non-selective adrenergic antagonists?
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*Selective: act at only 1 receptor
*Non-selective: act at >1 receptor |
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What Adrenergic Antagonist(s) act on some alpha and beta receptors?
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* Carvedilol – alpha 1, beta 1 and beta 2 (counteracts Dobutamine); anti-oxidant
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What Adrenergic Antagonist(s) are Alpha Selective (1 & 2)?
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* Phenoxybenzamine
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What Adrenergic Antagonist(s) are Beta Selective (1 & 2)?
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* Propanolol
* Timolol |
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What Adrenergic Antagonist(s) are Beta 1 Selective?
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Atenolol
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A drug ending in "-olol", is what type of drug?
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beta receptor antagonist
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What type of drug is Phenoxybenzamine?
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An Alpha Selective Adrenergic Receptor Antagonist
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What does Phenoxybenzamine do to the urinary sphincter?
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Relaxes Urinary Sphincter
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What does Phenoxybenzamine do to cutaneous blood flow?
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Increased cutaneous blood flow
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What does Phenoxybenzamine do to pupillary dilation, lid retraction, and nictitating membrane contraction?
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Prevents pupillary dilation, lid retraction, and nictitating membrane contraction
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What is Phenoxybenzamine commonly used for?
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Treatment of pheochromocytomas
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What type of drug is Propranolol?
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Beta Selective (1&2) Adrenergic Receptor Antagonist
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What is Propranolol commonly used for?
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Tx of hypertension and angina, glaucoma, myocardial infarction
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What are some common adverse effects of Propranolol?
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Bradycardia, decrease in cardiac output, fatigue
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What does Propranolol do to heart rate?
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Decreased heart rate
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What does Propranolol do to cardiac output?
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Diminished cardiac output
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What does Propranolol do to hepatic and renal blood flow?
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Decreased hepatic and renal blood flow
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What does Propranolol do to blood pressure?
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Lowered Blood pressure
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What does Propranolol do to Isoproterenol-induced tachycardia?
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Inhibits Isoproterenol-induced tachycardia
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Does Propranolol cause bronchoconstriction or bronchodilation?
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Bronchoconstriction
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What does Propranolol do with regards to migraines?
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Prevents migraines
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What does Propranolol do to uterine activity?
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Increased uterine activity
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What does Propranolol do to platelet aggregation?
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Decreased platelet aggregation
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What does Propranolol do to the number of circulating eosinophils?
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Increased number of circulating eosinophils
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What type of drug is Timolol?
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Beta Selective (1&2) Adrenergic Antagonist
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What does Timolol do to blood pressure?
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Lowers blood pressure
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What does Timolol do with regards to migraines?
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Prevents Migraines
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What does Timolol do to aqueous humor production in eye?
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Reduces aqueous humor production in eye
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What does Timolol do to heart rate?
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Decreased heart rate
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What does Timolol do to cardiac output?
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Diminished cardiac output
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What type of drug is Atenolol?
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Beta 1 Adrenergic Antagonist
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What does Atenolol do to contractility of the heart?
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Decreases contractility of the heart
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What does Atenolol do to heart rate?
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Decreases heart rate
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What does Atenolol do to cardiac output?
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Lowered cardiac output
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What does Atenolol do to blood pressure ?
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Lowered blood pressure
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What is Atenolol commonly used for?
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Tx of hypertension, glaucoma, myocardial infarction
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What are some adverse effects of Atenolol?
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Induction of congestive heart failure, life threatening increase in airway resistance, fatigue, depression
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What type of drug is Carvedilol?
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Alpha 1, Beta 1&2 adrenergic antagonist
* Free radical scavenger; anti-oxidant |
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What does Carvedilol do to the vasculature?
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Increased vasodilation
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What does Carvedilol do to the afterload of the heart?
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Reduced afterload of the heart
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What does Carvedilol do to blood pressure?
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Lowered Blood pressure
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What does Carvedilol do to heart rate?
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Decreased heart rate
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What does Carvedilol do to cardiac output?
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Diminished cardiac output
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