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14 Cards in this Set
- Front
- Back
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What are the 3 ACE inhibitors discussed in class?
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1. Captopril
2. Enalapril maleate 3. Benazepril |
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What is the primary MOA of ACE inhibitors?
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Inhibiting angiotensin I to angiotensin II
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What stimulates renin release from kidney JG cells?
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Reduced renal perfusion (i.e. decreased BP)
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What does Renin stimulate the formation of?
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Stimulates formation of angiotensin I, which is then metabolized by ACE (in lungs) to angiotensin II
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What is the effect of Angiotensin II?
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vasoconstriction
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What does Angiotensin to stimulate?
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Stimulates release of aldosterone
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What effect does Aldosterone have in the kidneys?
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Increased Na+ and water retention at kidney
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What are the 2 major effects of ACE inhibitors?
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• Cause peripheral vasodilation
• Facilitate Na+ excretion and diuresis |
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What are the cardiovascular effects of ACE inhibitors?
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* Decreased pulmonary capillary and arterial pressure
* Decreased HR, decreased BP |
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What are ACE inhibitors commonly used for?
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treatment of classes of heart failure
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What are some adverse effects of ACE inhibitors?
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* Should monitor renal function during administration to ensure adequate perfusion of kidneys
* May see sporadic cases of azotemia * Should limit concurrent use of diuretics and NSAIDs * May see coughing and angioedema |
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What are some drug interactions to keep in mind when giving an ACE inhibitor?
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* ACE inhibitors potentiate effect of diuretics and should be co-administered with great caution
* ACE inhibitors given with NSAIDs will have diminished effect |
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Where is Enalapril metabolized?
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Kidney
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Where are Benazepril and Ramipril metabolized?
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both liver and kidney
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