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42 Cards in this Set

  • Front
  • Back
Amount of drug that must bind for you to see an effect
receptor occupancy
receptor/drug complex
Which disease processes cause a change in pH
DKA
Sepsis
kidney failure
liver failure
lactic acidosis
dehydration
COPD
What will uremia do to the free fraction of your drug
increase
Oxydation and reduction reactions occur in this phase of metabolism
phase 1
Drugs that do not undergo enzyme induction
esters
When do enzymes reach adult levels in infants
1 year of age
When do children have higher rates of drug metabolism than adults
2-15 years old
What does surgery with general anesthesia do to the blood flow to the liver
decreases
Cholinergic branch of the RAS
Thalamic
Monoaminergic branch of the RAS
Hypothalamic
Wave of alert wakefulness
Beta
Wave of quiet wakefulness
Alpha
Antidotes for intraarterial injections of barbituates
papaverine
phentolamine
Can cause apnea at any dose
Midazolam
What are the neuroprotective drugs
Barbs
Propofol
Etomidate
Which induction agents are acids
Barbituates and Propofol
Which induction agents would you decrease your dose with in low protein states
Precedex
Which induction agents are coupled
Barbituates
Propofol
Which induction agents are uncoupled
Etomidate
Precedex
Which induction agents cause an increase in CMRO2 and CBF
Ketamine
Which induction agents can cause burst suppression
Barbs
Propofol
Etomidate
Which induction agents provide analgesia
Dexmedtomidine
Ketamine
Which induction agents are painful on injection
Brevital
Diprivan
Etomidate
Induction drug that displaces coumadin
Brevital
Which induction agent causes adrenocorticol suppression
Etomidate
Which drugs provide reliable amnesia
BZD
Barbituates
Ketamine
Which induction agents are used for seizure mapping
Brevital
Etomidate
What drug should be used to reverse bradycardia in Propofol infusion syndrome
isoproterenol
How do you prevent myoclonus when adminstering etomidate
pretreat with etomidate
Which induction agent causes and increased PVR and pulmonary arterial pressure
ketamine
What does the alpha 2 A subtype do
sedation
sympatholysis
hypnosis
analgesia
What does the alpha 2 B subtype do
analgesia
antishivering
Vasoconstriction
Induction drugs that decrease ICP
Barbs
Propofol
etomidate*
Drugs that undergo Phase 2 metabolism
lorazepam
propofol
Induction drugs that decrease IOP
Etomidate
Barbs
propofol
Drugs that decrease baroreceptor sensitivity
BZD
propofol
total amount of the drug present/ concentration in the plasma
Vd
What is the definition of context sensitive half life
time to decrease plasma concentration by one half after stopping an IV infusion
Induction agent that causes coronary artery vasoconstriction
dexmedetomidine
Duration of versed
15-80 minutes
Great drug for preventing rebound HTN during post-op weaning of opioids and anesthesia
precedex
Reversal agent for precedex
atipamezole