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42 Cards in this Set
- Front
- Back
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Amount of drug that must bind for you to see an effect
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receptor occupancy
receptor/drug complex |
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Which disease processes cause a change in pH
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DKA
Sepsis kidney failure liver failure lactic acidosis dehydration COPD |
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What will uremia do to the free fraction of your drug
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increase
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Oxydation and reduction reactions occur in this phase of metabolism
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phase 1
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Drugs that do not undergo enzyme induction
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esters
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When do enzymes reach adult levels in infants
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1 year of age
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When do children have higher rates of drug metabolism than adults
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2-15 years old
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What does surgery with general anesthesia do to the blood flow to the liver
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decreases
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Cholinergic branch of the RAS
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Thalamic
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Monoaminergic branch of the RAS
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Hypothalamic
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Wave of alert wakefulness
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Beta
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Wave of quiet wakefulness
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Alpha
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Antidotes for intraarterial injections of barbituates
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papaverine
phentolamine |
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Can cause apnea at any dose
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Midazolam
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What are the neuroprotective drugs
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Barbs
Propofol Etomidate |
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Which induction agents are acids
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Barbituates and Propofol
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Which induction agents would you decrease your dose with in low protein states
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Precedex
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Which induction agents are coupled
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Barbituates
Propofol |
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Which induction agents are uncoupled
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Etomidate
Precedex |
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Which induction agents cause an increase in CMRO2 and CBF
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Ketamine
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Which induction agents can cause burst suppression
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Barbs
Propofol Etomidate |
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Which induction agents provide analgesia
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Dexmedtomidine
Ketamine |
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Which induction agents are painful on injection
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Brevital
Diprivan Etomidate |
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Induction drug that displaces coumadin
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Brevital
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Which induction agent causes adrenocorticol suppression
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Etomidate
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Which drugs provide reliable amnesia
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BZD
Barbituates Ketamine |
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Which induction agents are used for seizure mapping
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Brevital
Etomidate |
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What drug should be used to reverse bradycardia in Propofol infusion syndrome
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isoproterenol
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How do you prevent myoclonus when adminstering etomidate
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pretreat with etomidate
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Which induction agent causes and increased PVR and pulmonary arterial pressure
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ketamine
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What does the alpha 2 A subtype do
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sedation
sympatholysis hypnosis analgesia |
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What does the alpha 2 B subtype do
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analgesia
antishivering Vasoconstriction |
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Induction drugs that decrease ICP
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Barbs
Propofol etomidate* |
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Drugs that undergo Phase 2 metabolism
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lorazepam
propofol |
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Induction drugs that decrease IOP
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Etomidate
Barbs propofol |
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Drugs that decrease baroreceptor sensitivity
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BZD
propofol |
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total amount of the drug present/ concentration in the plasma
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Vd
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What is the definition of context sensitive half life
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time to decrease plasma concentration by one half after stopping an IV infusion
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Induction agent that causes coronary artery vasoconstriction
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dexmedetomidine
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Duration of versed
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15-80 minutes
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Great drug for preventing rebound HTN during post-op weaning of opioids and anesthesia
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precedex
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Reversal agent for precedex
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atipamezole
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