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10 Cards in this Set
- Front
- Back
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What antihypertensive medication is used in the prophylaxis of migraine headache
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Propranolol
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Give examples of medications in the “triptan” drug class
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Sumatriptan; Almotriptan; Naratriptan; Rizatriptan; Zolmitriptan
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What is the mechanism of action of sumatriptan
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5-HT1D receptor agonist which causes vasoconstriction in cranial arteries
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Why should sumatriptan be used with caution in a patient with angina
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Can precipitate an anginal attack secondary to vasospasm of coronary arteries
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How long after the first dose can a second dose of sumatriptan be given if migraine headache has not resolved
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Dose may be repeated once after 2 hours
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What is the mechanism of action of the ergot alkaloids
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Causes vasoconstriction of cranial arteries less selectively than “triptans” by acting as an agonist of various 5-HT receptors throughout the body
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Give an example of an ergot alkaloid
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Ergotamine; Ergonovine
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What are some common side effects of ergotamine
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Nausea; Vomiting; Diarrhea; Chest pain; Toxic levels can cause gangrene
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Why is ergotamine sometimes given with caffeine
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Increased gut absorption
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Are opioids analgesics usually effective against migraine headache
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No
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